@article {1538326,
	title = {Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma},
	journal = {Curr Eye Res},
	volume = {46},
	number = {6},
	year = {2021},
	month = {2021 Jun},
	pages = {895-902},
	abstract = {PURPOSE: To determine the clinical relevance of prelaminar wedge defects (PLWDs) detected by swept-source optical coherence tomography (SS-OCT) in primary open-angle glaucoma (POAG). MATERIALS AND METHODS: In this retrospective case-control study, PLWDs were defined as triangular-shaped defects at the surface of the optic nerve prelaminar tissue, not adjacent to blood vessels, present on cross-sectional SS-OCT scans. Two observers masked to diagnosis independently reviewed scans to detect PLWDs and lamina cribrosa defects. History of disc hemorrhage, occurring within 2\&nbsp;years prior to imaging, was obtained from chart review. One eye per subject was randomly selected. Two-sided t-tests, analysis of variance with Bonferroni correction, and multivariable logistic regression analysis were performed to explore demographic and clinical features associated with PLWDs. RESULTS: 40 POAG and 23 control eyes were included. PLWDS were found in 27.5\% of POAG (n\&nbsp;=\&nbsp;11) and 4.3\% of controls (n\&nbsp;=\&nbsp;1, p =\&nbsp;.04). Eyes with repeat SS-OCT imaging (7 POAG and 0 controls) had persistent PLWDs. More POAG eyes with PLWDs had a history of disc hemorrhage (45.5\%) than POAG eyes without PLWDs (3.4\%, p =\&nbsp;.004). On multivariable analysis, compared to POAG without PLWDs, POAG with PLWDs had increased odds of observed disc hemorrhage (OR\&nbsp;=\&nbsp;21.6, 95\% CI, 2.2-589.0, p =\&nbsp;.02) after adjusting for age, gender, visual field mean deviation and maximum intraocular pressure (IOP). POAG with PLWDs had more lamina cribrosa defects (45.5\%) than POAG without PLWDs (3.4\%, p =\&nbsp;.01) but did not differ significantly from controls (8.7\%, p =\&nbsp;.07). Compared to all patients without PLWDs, patients with PLWDs had increased odds of having lamina cribrosa defects (OR\&nbsp;=\&nbsp;44.8; 95\% CI, 6.3-703.6, p \&lt;\&nbsp;.001) after adjusting for age, gender, and maximum IOP. CONCLUSIONS: PLWDs were more frequently found in POAG than control eyes and were associated with a history of disc hemorrhage and lamina cribrosa defects. PLWDs may be a useful imaging biomarker of glaucomatous damage.},
	issn = {1460-2202},
	doi = {10.1080/02713683.2020.1836229},
	author = {Chiou, Carolina A and Wang, Mengyu and Taniguchi, Elise V and Silva, Rafaella Nascimento E and Khoroshilov, Anna and Li, Dian and Wang, Haobing and Greenstein, Scott H and Brauner, Stacey C and Turalba, Angela V and Pasquale, Louis R and Shen, Lucy Q}
}
