@article {1538330,
	title = {Interaction Between the Distribution of Diabetic Retinopathy Lesions and the Association of Optical Coherence Tomography Angiography Scans With Diabetic Retinopathy Severity},
	journal = {JAMA Ophthalmol},
	volume = {138},
	number = {12},
	year = {2020},
	month = {2020 Dec 01},
	pages = {1291-1297},
	abstract = {Importance: Studies have not yet determined whether the distribution of lesions in the retinal periphery alters the association between the severity of diabetic retinopathy (DR) and macular vessel density. Objective: To evaluate the association of DR lesion distribution with optical coherence tomography angiography (OCTA) metrics and DR severity. Design, Setting, and Participants: This cross-sectional observational study was conducted at a tertiary care center for diabetic eye disease among 225 patients with type 1 or 2 diabetes who had undergone imaging between February 15, 2016, and December 31, 2019. Exposures: Optical coherence tomography angiography 3 {\texttimes} 3-mm macular scans and ultra-widefield color imaging. Main Outcomes and Measures: Optical coherence tomography angiography vessel density in the superficial capillary plexus, intermediate capillary plexus, and deep capillary plexus and choriocapillaris flow density. The severity of DR and the predominantly peripheral lesions (PPL) were evaluated from ultra-widefield color imaging. Results: The study evaluated 352 eyes (225 patients; 125 men [55.6\%]; mean [SD] age, 52.1 [15.1] years), of which 183 eyes (52.0\%) had mild nonproliferative diabetic retinopathy (NPDR), 71 eyes (20.2\%) had moderate NPDR, and 98 eyes (27.8\%) had severe NPDR or proliferative diabetic retinopathy (PDR). In eyes with no PPL (209 [59.4\%]), the mean (SD) vessel density in the superficial capillary plexus (mild NPDR, 38.1\% [4.7\%]; moderate NPDR, 36.4\% [4.6\%]; severe NPDR or PDR, 34.1\% [4.1\%]; P \&lt; .001) and the deep capillary plexus (mild NPDR, 45.8\% [3.0\%]; moderate NPDR, 45.8\% [2.2\%]; severe NPDR or PDR, 44.5\% [1.9\%]; P = .002), as well as the mean (SD) choriocapillaris flow density (mild NPDR, 69.7\% [6.2\%]; moderate NPDR, 67.6\% [5.6\%]; severe NPDR or PDR, 67.1\% [5.6\%]; P = .01), decreased with increasing DR severity. These associations remained statistically significant even after correcting for age, signal strength index, spherical equivalent, duration of diabetes, type of diabetes, and correlation between eyes of the same patient. In eyes with PPL (143 [40.6\%]), mean (SD) vessel density in the superficial capillary plexus (mild NPDR, 34.1\% [4.1\%]; moderate NPDR, 35.2\% [4.1\%]; severe NPDR or PDR, 36.0\% [4.3\%]; P = .42) and the deep capillary plexus (mild NPDR, 44.5\% [1.7\%]; moderate NPDR, 45.4\% [1.4\%]; severe NPDR or PDR, 44.9\% [1.5\%]; P = .81), as well as the mean (SD) choriocapillaris flow density (mild NPDR, 67.1\% [5.6\%]; moderate NPDR, 69.3\% [4.6\%]; severe NPDR or PDR, 68.3\% [5.6\%]; P = .49), did not appear to change with increasing DR severity. Conclusions and Relevance: These results suggest that central retinal vessel density is associated with DR severity in eyes without, but not with, PPL. These findings suggest a potential need to stratify future optical coherence tomography angiography studies of eyes with DR by the presence or absence of PPL. If DR onset and worsening are associated with the location of retinal nonperfusion, assessment of global retinal nonperfusion using widefield angiography may improve the ability to evaluate DR severity and risk of DR worsening over time.},
	issn = {2168-6173},
	doi = {10.1001/jamaophthalmol.2020.4516},
	author = {Ashraf, Mohamed and Sampani, Konstantina and Rageh, Abdulrahman and Silva, Paolo S and Aiello, Lloyd Paul and Sun, Jennifer K}
}
