@article {1549023,
	title = {The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis},
	journal = {Ocul Immunol Inflamm},
	year = {2020},
	month = {2020 Nov 17},
	pages = {1-11},
	abstract = {Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Multicentre retrospective analysis. A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n\&nbsp;=\&nbsp;382/447; 85.4\%) and 382 received corticosteroids (n\&nbsp;=\&nbsp;382/447; 85.4\%). Treatment failure was observed in 78 individuals (n\&nbsp;=\&nbsp;78/447; 17.4\%), occurring less frequently in patients receiving ATT (n\&nbsp;=\&nbsp;66/382; 17.2\%) compared to those who did not (n\&nbsp;=\&nbsp;12/65; 18.5\%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.},
	issn = {1744-5078},
	doi = {10.1080/09273948.2020.1808226},
	author = {Agrawal, Rupesh and Betzler, Bjorn Kaijun and Testi, Ilaria and Mahajan, Sarakshi and Agarwal, Aniruddha and Gunasekeran, Dinesh Visva and Raje, Dhananjay and Aggarwal, Kanika and Murthy, Somasheila I and Westcott, Mark and Chee, Soon-Phaik and McCluskey, Peter and Ho, Su Ling and Teoh, Stephen and Cimino, Luca and Biswas, Jyotirmay and Narain, Shishir and Agarwal, Manisha and Mahendradas, Padmamalini and Khairallah, Moncef and Jones, Nicholas and Tugal-Tutkun, Ilknur and Babu, Kalpana and Basu, Soumayava and Carre{\~n}o, Ester and Lee, Richard and Al-Dhibi, Hassan and Bodaghi, Bahram and Invernizzi, Alessandro and Goldstein, Debra A and Barisani-Asenbauer, Talin and Gonz{\'a}lez-L{\'o}pez, Julio J and Androudi, Sofia and Bansal, Reema and Moharana, Bruttendu and Esposti, Simona Degli and Tasiopoulou, Anastasia and Nadarajah, Sengal and Agarwal, Mamta and Abraham, Sharanaya and Vala, Ruchi and Singh, Ramandeep and Sharma, Aman and Sharma, Kusum and Zierhut, Manfred and Kon, Onn Min and Cunningham, Emmett T and Kempen, John H and Nguyen, Quan Dong and Pavesio, Carlos and Gupta, Vishali}
}
