@article {1549033,
	title = {Disorganisation of retinal inner layers is associated with reduced contrast sensitivity in retinal vein occlusion},
	journal = {Br J Ophthalmol},
	volume = {106},
	number = {2},
	year = {2022},
	month = {2022 Feb},
	pages = {241-245},
	abstract = {BACKGROUND/AIMS: To determine if disorganisation of retinal inner layers (DRIL) is associated with reduced contrast sensitivity (CS) in patients with retinal vein occlusion (RVO) with a history of macular oedema (ME). METHODS: Prospective, observational cohort study. Patients with a history of ME secondary to central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) from October 2017 to July 2019 at a single institution were included. Patients underwent complete ophthalmic examination, spectral domain optical coherence tomography (SD-OCT) and CS testing using the quick contrast sensitivity function (qCSF) method. Eyes with coexisting macular disease were excluded. SD-OCT images were analysed for presence and extent of DRIL, intraretinal fluid (IRF), subretinal fluid (SRF), hyperreflective foci, epiretinal membrane (ERM), external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption, central macular thickness (CMT) and central foveal thickness (CFT). Multivariable mixed-effect linear regressions were performed for the area under the log contrast sensitivity function (AULCSF) using Stata (StataCorp). P values \&lt;0.05 were considered significant. RESULTS: 58 visits from 31 patients were included (1.9{\textpm}1.2 visits per patient). 29 (50\%) were for CRVO. The average age was 63.9{\textpm}10.5\&nbsp;years. On multivariable analysis, DRIL extent (p\&lt;0.001), CMT (p=0.007), CFT (p=0.024) and moderate cataract (p=0.001) were significantly associated with worse AULCSF. CONCLUSIONS: DRIL extent is associated with reduced CS in eyes with ME secondary to RVO. DRIL is an imaging feature that has important implications for visual function.},
	issn = {1468-2079},
	doi = {10.1136/bjophthalmol-2020-317615},
	author = {Wang, Jay and Cui, Ying and Vingopoulos, Filippos and Kasetty, Megan and Silverman, Rebecca F and Katz, Raviv and Kim, Leo and Miller, John B}
}
