@article {1559562,
	title = {Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment},
	journal = {Aging (Albany NY)},
	volume = {12},
	year = {2020},
	month = {2020 Dec 29},
	abstract = {Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD), in a retinal detachment (RD) induced photoreceptor degeneration. NMN administration after RD resulted in a significant reduction of TUNEL photoreceptors, CD11b macrophages, and GFAP labeled glial activation; a normalization of protein carbonyl content (PCC), and a preservation of the outer nuclear layer (ONL) thickness. NMN administration significantly increased NAD levels, SIRT1 protein expression, and heme oxygenase-1 (HO-1) expression. Delayed NMN administration still exerted protective effects after RD. Mechanistic studies using 661W cells revealed a SIRT1/HO-1 signaling as a downstream effector of NMN-mediated protection under oxidative stress and LPS stimulation. In conclusion, NMN administration exerts neuroprotective effects on photoreceptors after RD and oxidative injury, suggesting a therapeutic avenue to treating photoreceptor degeneration.},
	issn = {1945-4589},
	doi = {10.18632/aging.202453},
	author = {Chen, XiaoHong and Amorim, Jo{\~a}o A and Moustafa, Giannis A and Lee, Jong-Jer and Yu, Zhen and Ishihara, Kenji and Iesato, Yasuhiro and Barbisan, Paulo and Ueta, Takashi and Togka, Konstantina A and Lu, Lin and Sinclair, David A and Vavvas, Demetrios G}
}
