@article {1573099,
	title = {Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia},
	journal = {PLoS One},
	volume = {16},
	number = {1},
	year = {2021},
	month = {2021},
	pages = {e0244320},
	abstract = {In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)-to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as "switched off" in generalized allodynia.},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0244320},
	author = {Maleki, Nasim and Szabo, Edina and Becerra, Lino and Moulton, Eric and Scrivani, Steven J and Burstein, Rami and Borsook, David}
}
