@article {1580507,
	title = {Rapid reduction of macular edema due to retinal vein occlusion with low-dose normobaric hyperoxia},
	journal = {Graefes Arch Clin Exp Ophthalmol},
	volume = {259},
	number = {8},
	year = {2021},
	month = {2021 Aug},
	pages = {2113-2118},
	abstract = {PURPOSE: We investigated the effects of a relatively inexpensive, non-invasive, short-term treatment with low-dose normobaric hyperoxia (NBH) on macular edema in patients with retinal vein occlusion (RVO). METHODS: Participants with macular edema associated with RVO were treated with 5 LPM of NBH via facemask (40\% fraction of inspired oxygen, FIO2) for 3 h. Patients with non-fovea involving edema who elected to be observed returned for a second treatment 1 month later to test reproducibility. RESULTS: A 3-h session of NBH (n = 45) resulted in decreased maximum macular thickness (MMT) (mean 7.10\%, t34=9.63 P\&lt;.001) and central macular thickness (CMT) (mean 4.64\%, t34=6.90, P\&lt;.001) when compared to untreated eyes with RVO measured over the same period of time (n = 12) or their healthy fellow eye (n = 34; MMT:t34=-9.60, P\&lt;.001;CMT: t34=-6.72, P\&lt;.001). Patients who had a second NBH treatment 1 month later experienced a recurrence of their edema, but demonstrated a similar significant reduction in MMT and CMT after the second NBH treatment. CONCLUSIONS: Three-hour treatment with 40\% FIO2 NBH results in a significant reduction in MMT and CMT. This study supports an ischemic mechanism for macular edema associated with retinal vein occlusion. TRANSLATIONAL RELEVANCE: Short-term low-dose normobaric hyperoxia is a simple, inexpensive, and ubiquitous treatment that may provide an alternate or adjunctive approach to treating macular edema in patients who are resistant to or cannot afford anti-VEGF medications.},
	keywords = {Humans, Hyperoxia, Intravitreal Injections, Macular Edema, Reproducibility of Results, Retinal Vein Occlusion, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity},
	issn = {1435-702X},
	doi = {10.1007/s00417-021-05128-w},
	author = {Arroyo, Jorge G and Seto, Brendan and Yamada, Keiko and Zeng, Ke and Minturn, Robert and Lemire, Colin A}
}
