@article {1580508,
	title = {Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries},
	journal = {Nat Commun},
	volume = {12},
	number = {1},
	year = {2021},
	month = {2021 02 24},
	pages = {1258},
	abstract = {Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.},
	issn = {2041-1723},
	doi = {10.1038/s41467-020-20851-4},
	author = {Gharahkhani, Puya and Jorgenson, Eric and Hysi, Pirro and Khawaja, Anthony P and Pendergrass, Sarah and Han, Xikun and Ong, Jue Sheng and Hewitt, Alex W and Segr{\`e}, Ayellet V and Rouhana, John M and Hamel, Andrew R and Igo, Robert P and Choquet, Helene and Qassim, Ayub and Josyula, Navya S and Cooke Bailey, Jessica N and Bonnemaijer, Pieter W M and Iglesias, Adriana and Siggs, Owen M and Young, Terri L and Vitart, Veronique and Thiadens, Alberta A H J and Karjalainen, Juha and Uebe, Steffen and Melles, Ronald B and Nair, K Saidas and Luben, Robert and Simcoe, Mark and Amersinghe, Nishani and Cree, Angela J and Hohn, Rene and Poplawski, Alicia and Chen, Li Jia and Rong, Shi-Song and Aung, Tin and Vithana, Eranga Nishanthie and NEIGHBORHOOD Consortium and ANZRAG Consortium and BioBank Japan Project and FinnGen study and UK Biobank Eye and Vision Consortium and GIGA Study Group and 23andMe Research Team and Tamiya, Gen and Shiga, Yukihiro and Yamamoto, Masayuki and Nakazawa, Toru and Currant, Hannah and Birney, Ewan and Wang, Xin and Auton, Adam and Lupton, Michelle K and Martin, Nicholas G and Ashaye, Adeyinka and Olawoye, Olusola and Williams, Susan E and Akafo, Stephen and Ramsay, Michele and Hashimoto, Kazuki and Kamatani, Yoichiro and Akiyama, Masato and Momozawa, Yukihide and Foster, Paul J and Khaw, Peng T and Morgan, James E and Strouthidis, Nicholas G and Kraft, Peter and Kang, Jae H and Pang, Chi Pui and Pasutto, Francesca and Mitchell, Paul and Lotery, Andrew J and Palotie, Aarno and van Duijn, Cornelia and Haines, Jonathan L and Hammond, Chris and Pasquale, Louis R and Klaver, Caroline C W and Hauser, Michael and Khor, Chiea Chuen and Mackey, David A and Kubo, Michiaki and Cheng, Ching-Yu and Craig, Jamie E and Macgregor, Stuart and Wiggs, Janey L}
}
