@article {1586152,
	title = {Advanced nanodelivery platforms for topical ophthalmic drug delivery},
	journal = {Drug Discov Today},
	volume = {26},
	number = {6},
	year = {2021},
	month = {2021 Jun},
	pages = {1437-1449},
	abstract = {Conventional eye drops have several limitations, including the need for multiple applications per dose, hourly based dosage regiments, and suboptimal ocular bioavailability (\&lt;5\%). The efficacy of topical ophthalmic medications can be significantly improved by controlling their contact time with the adherent mucin layer and by inducing sustained release properties, thus allowing for a prolonged contact time of the drug with the ocular tissues, which eventually will lead to improved drug bioavailability and a significant decrease in the frequency of eyedrop instillation. In this review, we critically highlight recent and innovative nanodrug delivery platforms, with a primary focus on the integration of nanotechnology, biomaterials, and polymer chemistry to facilitate precise spatial and temporal control over sustained drug release to the cornea.},
	issn = {1878-5832},
	doi = {10.1016/j.drudis.2021.02.027},
	author = {Gholizadeh, Shima and Wang, Ziqing and Chen, Xi and Dana, Reza and Annabi, Nasim}
}
