@article {1589753,
	title = {AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa},
	journal = {Elife},
	volume = {10},
	year = {2021},
	month = {2021 04 13},
	abstract = {Retinitis pigmentosa (RP) is an inherited retinal disease affecting \&gt;20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity vision. Currently, there is no effective treatment for RP, other than gene therapy for a limited number of specific disease genes. To develop a disease gene-agnostic therapy, we screened 20 genes for their ability to prolong cone photoreceptor survival in vivo. Here, we report an adeno-associated virus vector expressing Txnip, which prolongs the survival of cone photoreceptors and improves visual acuity in RP mouse models. A allele, C247S, which blocks the association of Txnip with thioredoxin, provides an even greater benefit. Additionally, the rescue effect of Txnip depends on lactate dehydrogenase b (Ldhb) and correlates with the presence of healthier mitochondria, suggesting that Txnip saves RP cones by enhancing their lactate catabolism.},
	issn = {2050-084X},
	doi = {10.7554/eLife.66240},
	author = {Xue, Yunlu and Wang, Sean K and Rana, Parimal and West, Emma R and Hong, Christin M and Feng, Helian and Wu, David M and Cepko, Constance L}
}
