@article {1593831,
	title = {Management of belantamab mafodotin-associated corneal events in patients with relapsed or refractory multiple myeloma (RRMM)},
	journal = {Blood Cancer J},
	volume = {11},
	number = {5},
	year = {2021},
	month = {2021 May 26},
	pages = {103},
	abstract = {Belantamab mafodotin (belamaf) demonstrated deep and durable responses in patients with heavily pretreated relapsed or refractory multiple myeloma (RRMM) in DREAMM-2 (NCT03525678). Corneal events, specifically keratopathy (including superficial punctate keratopathy and/or microcyst-like epithelial changes (MECs), eye examination findings with/without symptoms), were common, consistent with reports from other antibody-drug conjugates. Given the novel nature of corneal events in RRMM management, guidelines are required for their prompt identification and appropriate management. Eye examination findings from DREAMM-2 and insights from hematology/oncology investigators and ophthalmologists, including corneal specialists, were collated and used to develop corneal event management guidelines. The following recommendations were formulated: close collaboration among hematologist/oncologists and eye care professionals is needed, in part, to provide optimal care in relation to the belamaf benefit-risk profile. Patients receiving belamaf should undergo eye examinations before and during every treatment cycle and promptly upon worsening of symptoms. Severity of corneal events should be determined based on corneal examination findings and changes in best-corrected visual acuity. Treatment decisions, including dose modifications, should be based on the most severe finding present. These guidelines are recommended for the assessment and management of belamaf-associated ocular events to help mitigate ocular risk and enable patients to continue to experience a clinical benefit with belamaf.},
	issn = {2044-5385},
	doi = {10.1038/s41408-021-00494-4},
	author = {Lonial, Sagar and Nooka, Ajay K and Thulasi, Praneetha and Badros, Ashraf Z and Jeng, Bennie H and Callander, Natalie S and Potter, Heather A and Sborov, Douglas and Zaugg, Brian E and Popat, Rakesh and Esposti, Simona Degli and Byrne, Julie and Opalinska, Joanna and Baron, January and Piontek, Trisha and Gupta, Ira and Dana, Reza and Farooq, Asim V and Colby, Kathryn and Jakubowiak, Andrzej}
}
