@article {1603842,
	title = {Dry eye disease flares: A rapid evidence assessment},
	journal = {Ocul Surf},
	volume = {22},
	year = {2021},
	month = {2021 Jul 22},
	pages = {51-59},
	abstract = {PURPOSE: Characteristics of periodic flares of dry eye disease (DED) are not well understood. We conducted a rapid evidence assessment to identify evidence for and characteristics of DED flares. METHODS: Literature searches were performed in Embase{\textregistered} via Ovid{\textregistered}, MEDLINE{\textregistered}, and PubMed{\textregistered}. Clinical trials and observational studies published 2009-2019 were included if they investigated patients aged >=18 years with clinically diagnosed DED who experienced a flare, defined as a temporary or transient episode of increased ocular discomfort, typically lasting days to a few weeks. Triggers of flares, patient-reported outcomes (symptoms), clinician-measured outcomes (signs), and changes in tear molecules were captured. RESULTS: Twenty-one publications that included 22 studies met inclusion criteria. Five observational studies described evidence of DED flares in daily life, 5 studies reported changes following cataract/refractive surgery in patients with preoperative DED, and 12 studies employed controlled environment (CE) models. Real-world triggers of DED flares included air conditioning, wind, reading, low humidity, watching television, and pollution. CE chambers (dry, moving air) and surgery also triggered DED flares. Exacerbations of symptoms and signs of DED, assessed through varied measures, were reported during flares. Across studies, matrix metalloproteinase-9 and interleukin-6 increased and epidermal growth factor decreased during DED flares. CONCLUSIONS: Evidence from 22 studies identified triggers and characteristics of DED flares. Further research is needed to assist clinicians in early diagnosis and treatment of patients experiencing flares.},
	issn = {1937-5913},
	doi = {10.1016/j.jtos.2021.07.001},
	author = {Starr, Christopher E and Dana, Reza and Pflugfelder, Stephen C and Holland, Edward J and Zhang, Steven and Owen, Desiree and Brazzell, Kim}
}
