@article {1608581,
	title = {Chalcomoracin prevents vitreous-induced activation of AKT and migration of retinal pigment epithelial cells},
	journal = {J Cell Mol Med},
	volume = {25},
	number = {19},
	year = {2021},
	month = {2021 Oct},
	pages = {9102-9111},
	abstract = {Retinal pigment epithelial (RPE) cells are the major cell type in the epi- or sub-retinal membranes in the pathogenesis of proliferative vitreoretinopathy (PVR), which is a blinding fibrotic eye disease and still short of effective medicine. The purpose of this study is to demonstrate whether Chalocomoracin (CMR), a novel purified compound from fungus-infected mulberry leaves, is able to inhibit vitreous-induced signalling events and cellular responses intrinsic to PVR. Our studies have revealed that the CMR IC50 for ARPE-19 cells is 35.5\&nbsp;μmol/L at 72\&nbsp;hours, and that 5\&nbsp;μmol/L CMR inhibits vitreous-induced Akt activation and p53 suppression; in addition, we have discovered that this chemical effectively blocks vitreous-stimulated proliferation, migration and contraction of ARPE-19 cells, suggesting that CMR is a promising PVR prophylactic.},
	issn = {1582-4934},
	doi = {10.1111/jcmm.16590},
	author = {Han, Haote and Yang, Yanhui and Liu, Bing and Tian, Jingkui and Dong, Lijun and Qi, Hui and Zhu, Wei and Wang, Jiantao and Lei, Hetian}
}
