@article {1608605,
	title = {Demographic and prognostic factors of optic nerve astrocytoma: a retrospective study of surveillance, epidemiology, and end results (SEER)},
	journal = {BMC Cancer},
	volume = {21},
	number = {1},
	year = {2021},
	month = {2021 Aug 30},
	pages = {976},
	abstract = {BACKGROUND: Optic nerve astrocytomas (ONAs) are neurological neoplasms in the central nervous system (CNS), and they have the highest incidence rate among all the tumor types in the visual pathway. In this study, we conducted a Surveillance, Epidemiology, and End Results (SEER) -based research to explore the demographic, survival, and prognostic factors of patients diagnosed with ONAs. METHODS: Utilizing the SEER database, we retrospectively evaluated data of patients diagnosed with ONAs of all ages from 1984 to 2016. We used the Student{\textquoteright}s t distribution to test variables of patients and various characteristics, and Kaplan-Meier curve to illustrate overall survival (OS) with 95.0\% confidence intervals (CIs). We also performed univariate and multivariate analyses to evaluate various variables{\textquoteright} validity on overall survival. RESULTS: A total of 1004 cases were analyzed, and revealed that age (P\&lt;0.001, hazard ratio (HR) = 8.830, 95\% CI: 4.088-19.073), tumor grade (P\&lt;0.001, HR = 1.927, 95\% CI: 1.516-2.450), diagnostic confirmation (P\&lt;0.001, HR = 2.444, 95\% CI: 1.632-3.660), and histology type (P = 0.046, HR = 1.563, 95\% CI: 1.008-2.424) of the tumor were associated with decreased survival. CONCLUSIONS: From this large, comparative study of ONAs, we found that younger age may be considered as a protective indicator, while high-grade astrocytic tumors have a worse prognosis. We also found that diagnostic confirmation and tumor grade were independent prognostic factors in this patient population.},
	issn = {1471-2407},
	doi = {10.1186/s12885-021-08719-2},
	author = {Zhang, Mingui and Chen, Tao and Zhong, Yisheng}
}
