@article {1619428,
	title = {Longitudinal changes in daily patterns of objectively measured physical activity after falls in older adults with varying degrees of glaucoma},
	journal = {EClinicalMedicine},
	volume = {40},
	year = {2021},
	month = {2021 Oct},
	pages = {101097},
	abstract = {Background: Visually impaired older adults have a greater risk of falling, making them particularly susceptible to fall-related health consequences and restricted physical activity. Unclear however, is the relationship between having falls and longitudinal changes in daily patterns of objectively measured physical activity in older adults with visual impairments. Methods: We created a three-year prospective cohort study (Falls in Glaucoma Study) of older adults with primary or suspected glaucoma at the Johns Hopkins Wilmer Eye Institute from 2013 to 2015. Cumulative incidence of falls was determined through self-reported fall calendars over 12 months. Participants were then classified into one of three groups: multiple fallers (>=2 falls), single fallers (1 fall), and non-fallers (0). Daily physical activity was measured over 1 week using a waist-bound accelerometer during baseline and three-year follow-ups. Activity fragmentation was defined as the reciprocal of the mean activity bout length, with higher fragmentation reflecting shorter, more fractured bouts of continuous activity. Multivariate linear mixed-effects models were used to assess three-year longitudinal changes in: 1) activity fragmentation, and 2) accumulation of activity across six three-hour intervals from 5 AM to 11 PM. Findings: In adjusted models accounting for visual field damage and other factors, multiple fallers demonstrated greater annual declines (per year) in daily active bouts (-1.79 bouts/day, 95\% confidence interval [CI]: -3.35, -0.22), daily active minutes (-17.15\&nbsp;min/day, 95\% CI: -26.35, -7.94), and increased fragmentation (1\%, 95\% CI: 0, 2\%) over the three-year follow-up period as compared to non-fallers; no such changes were seen when comparing single fallers and non-fallers. In time-of-day analyses, multiple fallers experienced greater annual declines in average hourly steps over all periods of the day, though the rate of decline was only significant between 5 PM and 8 PM (-27.07 steps/hour, 95\% CI: -51.15, -2.99) compared to non-fallers. Interpretation: In an older population with visual impairment, multiple falls over 12 months were associated with more transient and fragmented activity over a subsequent three-year period, and activity declines during evening hours, compared to non-fallers. These findings suggest that multiple fallers with visual impairment may be at high risk for a decline in physical capacity and endurance, warranting clinical interventions. Funding: The research was supported in part by National Institutes of Health Grant EY022976.},
	issn = {2589-5370},
	doi = {10.1016/j.eclinm.2021.101097},
	author = {E, Jian-Yu and Mihailovic, Aleksandra and Schrack, Jennifer A and Garzon, Catalina and Li, Tianjing and Friedman, David S and West, Sheila K and Gitlin, Laura N and Ramulu, Pradeep Y}
}
