@article {1632283,
	title = {Hyperintensities of middle frontal gyrus in patients with diabetic optic neuropathy: a dynamic amplitude of low-frequency fluctuation study},
	journal = {Aging (Albany NY)},
	volume = {14},
	number = {3},
	year = {2022},
	month = {2022 Feb 04},
	pages = {1336-1350},
	abstract = {Diabetic optic neuropathy (DON) is a diverse complication of diabetes and its pathogenesis has not been fully elucidated. The purpose of this study was to explore dynamic cerebral activity changes in DON patients using dynamic amplitude of low-frequency fluctuation (dALFF). In total, 22 DON patients and 22 healthy controls were enrolled. The dALFF approach was used in all participants to investigate dynamic intrinsic brain activity differences between the two groups. Compared with HCs, DON patients exhibited significantly increased dALFF variability in the right middle frontal gyrus (P \&lt; 0.01). Conversely, DON patients exhibited obviously decreased dALFF variability in the right precuneus (P \&lt; 0.01). We also found that there were significant negative correlations between HADS scores and dALFF values of the right middle frontal gyrus in the DON patients (r = -0.6404, P \&lt;0.01 for anxiety and r = -0.6346, P \&lt;0.01 for depression; HADS, Hospital Anxiety and Depression Scale). Abnormal variability of dALFF was observed in specific areas of the cerebrum in DON patients, which may contribute to distinguishing patients with DON from HCs and a better understanding of DON, hyperintensities of right middle frontal gyrus may be potential diagnostic marker for DON.},
	issn = {1945-4589},
	doi = {10.18632/aging.203877},
	author = {Yang, Lin and Xiao, Ang and Li, Qiu-Yu and Zhong, Hui-Feng and Su, Ting and Shi, Wen-Qing and Ying, Ping and Liang, Rong-Bin and Xu, San-Hua and Shao, Yi and Zhou, Qiong}
}
