@article {1635625,
	title = {Computed tomography and [18F]-FDG PET imaging provide additional readouts for COVID-19 pathogenesis and therapies evaluation in non-human primates},
	journal = {iScience},
	volume = {25},
	number = {4},
	year = {2022},
	month = {2022 Apr 15},
	pages = {104101},
	abstract = {Non-human primates (NHPs) are particularly relevant as preclinical models for SARS-CoV-2 infection and nuclear imaging may represent a valuable tool for monitoring infection in this species. We investigated the benefit of computed X-ray tomography (CT) and [18F]-FDG positron emission tomography (PET) to monitor the early phase of the disease in a large cohort (n\&nbsp;= 76) of SARS-CoV-2 infected macaques. Following infection, animals showed mild COVID-19 symptoms including typical lung lesions. CT scores at the acute phase reflect the heterogeneity of lung burden following infection. Moreover, [18F]-FDG PET revealed that FDG uptake was significantly higher in the lungs, nasal cavities, lung-draining lymph nodes, and spleen of NHPs by 5\&nbsp;days postinfection compared to pre-infection levels, indicating early local inflammation. The comparison of CT and PET data from previous COVID-19 treatments or vaccines we tested in NHP, to this large cohort of untreated animals demonstrated the value of in\&nbsp;vivo imaging in preclinical trials.},
	issn = {2589-0042},
	doi = {10.1016/j.isci.2022.104101},
	author = {Naninck, Thibaut and Kahlaoui, Nidhal and Lemaitre, Julien and Maisonnasse, Pauline and De Mori, Antoine and Pascal, Quentin and Contreras, Vanessa and Marlin, Romain and Relouzat, Francis and Delache, Beno{\^\i}t and H{\'e}rate, C{\'e}cile and Aldon, Yoann and van Gils, Marit and Zabaleta, Nerea and Tsong Fang, Rapha{\"e}l Ho and Bosquet, Nathalie and Sanders, Rogier W and Vandenberghe, Luk H and Chapon, Catherine and Le Grand, Roger}
}
