@article {1635627,
	title = {Immune regulation of the ocular surface},
	journal = {Exp Eye Res},
	volume = {218},
	year = {2022},
	month = {2022 05},
	pages = {109007},
	abstract = {Despite constant exposure to various environmental stimuli, the ocular surface remains intact and uninflamed while maintaining the transparency of the cornea and its visual function. This {\textquoteright}immune privilege{\textquoteright} of the ocular surface is not simply a result of the physical barrier function of the mucosal lining but, more importantly, is actively maintained through a variety of immunoregulatory mechanisms that prevent the disruption of immune homeostasis. In this review, we focus on essential molecular and cellular players that promote immune quiescence in steady-state conditions and suppress inflammation in disease-states. Specifically, we examine the interactions between the ocular surface and its local draining lymphoid compartment, by encompassing the corneal epithelium, corneal nerves and cornea-resident myeloid cells, conjunctival goblet cells, and regulatory T cells (Treg) in the context of ocular surface autoimmune inflammation (dry eye disease) and alloimmunity (corneal transplantation). A better understanding of the immunoregulatory mechanisms will facilitate the development of novel, targeted immunomodulatory strategies for a broad range of ocular surface inflammatory disorders.},
	keywords = {Conjunctiva, Cornea, Corneal Transplantation, Dry Eye Syndromes, Humans, Inflammation},
	issn = {1096-0007},
	doi = {10.1016/j.exer.2022.109007},
	author = {Chen, Yihe and Wang, Shudan and Alemi, Hamid and Dohlman, Thomas and Dana, Reza}
}
