@article {1635660, title = {ASSESSMENT OF FLUORESCEIN ANGIOGRAPHY NONPERFUSION IN EYES WITH DIABETIC RETINOPATHY USING ULTRAWIDE FIELD RETINAL IMAGING}, journal = {Retina}, volume = {42}, number = {7}, year = {2022}, month = {2022 07 01}, pages = {1302-1310}, abstract = {PURPOSE: Evaluate association of retinal nonperfusion (NP) on ultrawide field (UWF) fluorescein angiography (FA) with diabetic retinopathy (DR) severity and predominantly peripheral lesions (PPL). METHODS: Multicenter observational study, 652 eyes (361 participants) having nonproliferative DR (NPDR) without center-involved diabetic macular edema in at least one eye. Baseline 200{\textdegree} UWF-color and UWF-FA images were graded by a central reading center for color-PPL and FA-PPL, respectively. UWF-FA was graded for NP index within concentric zones: posterior pole (\<10 mm from fovea), midperiphery (10-15 mm), and far periphery (\>15 mm). RESULTS: Baseline Early Treatment Diabetic Retinopathy Study DR severity was 31.7\% no DR/mild NPDR, 24.1\% moderate NPDR, 14.0\% moderately severe NPDR, 25.6\% severe/very severe NPDR, and 4.6\% proliferative DR. Worse DR severity was associated with increased NP index overall (P = 0.002), in the posterior pole (P \< 0.001), midperiphery (P \< 0.001), and far periphery (P = 0.03). On average, 29.6\% of imaged retinal NP was in the posterior pole, 33.7\% in midperiphery, and 36.7\% in far periphery. Increased NP index was associated with FA-PPL (P \< 0.001) but not with color-PPL (P = 0.65). CONCLUSION: Approximately, 70\% of NP in diabetic eyes is located outside the posterior pole. Increased NP is associated with the presence of FA-PPL, suggesting UWF-FA may better predict future DR worsening than UWF-color alone.}, keywords = {Diabetes Mellitus, Diabetic Retinopathy, Fluorescein Angiography, Humans, Macular Edema, Photography, Retina, Retinal Vessels}, issn = {1539-2864}, doi = {10.1097/IAE.0000000000003479}, author = {Silva, Paolo S and Liu, Danni and Glassman, Adam R and Aiello, Lloyd P and Grover, Sandeep and Kingsley, Ronald M and Melia, Michele and Sun, Jennifer K and DRCR Retina Network} }