@article {1638555,
	title = {Topical cenegermin 0.002\% for pediatric neurotrophic keratopathy},
	journal = {Eur J Ophthalmol},
	volume = {32},
	number = {6},
	year = {2022},
	month = {2022 Nov},
	pages = {3420-3424},
	abstract = {PURPOSE: To evaluate the efficacy and safety of cenegermin 0.002\% ophthalmic drops in the management of pediatric neurotrophic keratopathy (NK). METHODS: Retrospective chart review of children under the age of 18 years diagnosed with NK at Boston Children{\textquoteright}s Hospital/Massachusetts Eye and Ear Infirmary and treated with topical cenegermin 0.002\% ophthalmic solution between June 2018 and June 2021 was performed. Data collection included etiology of NK, age at time of initiation of topical cenegermin, laterality, ethnicity, gender, history of previous ocular therapy, pre- and post-therapy best corrected visual acuity, pre- and post-therapy cornea examination, any adverse events from topical cenegermin, associated ocular conditions, and history of ocular surgeries. RESULTS: The current study includes four eyes of four pediatric patients with a mean age of 4.5 {\textpm} 2.0 years at the time of initiation of topical cenegermin therapy. The mean time from NK diagnosis until start of topical cenegermin drops was 5.2 {\textpm} 4.3 months and mean follow-up time was 15 {\textpm} 9.6 months. In all four patients, marked improvement in epitheliopathy was demonstrated after completion of therapy. Best corrected visual acuity was measurable in 3 eyes of 3 patients, and it improved from a mean of 0.07 {\textpm} 0.01 to a mean of 0.29 {\textpm} 0.26 (P = 0.3). No adverse events related to cenegermin therapy were noted. CONCLUSION: Topical cenegermin was effective in improving corneal healing for pediatric NK.},
	keywords = {Adolescent, Child, Child, Preschool, Cornea, Corneal Dystrophies, Hereditary, Humans, Keratitis, Nerve Growth Factor, Ophthalmic Solutions, Recombinant Proteins, Retrospective Studies, Trigeminal Nerve Diseases},
	issn = {1724-6016},
	doi = {10.1177/11206721221094783},
	author = {Elhusseiny, Abdelrahman M and Traish, Aisha S and Saeed, Hajirah N and Mantagos, Iason S}
}
