@article {1638570,
	title = {Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells{\textquoteright} response to Pten deletion},
	journal = {Proc Natl Acad Sci U S A},
	volume = {119},
	number = {15},
	year = {2022},
	month = {2022 Apr 12},
	pages = {e2113751119},
	abstract = {SignificanceThe optic nerve conveys information from retinal ganglion cells (RGCs) to visual processing areas of the brain. Although this pathway normally cannot regenerate when injured nor in degenerative diseases such as glaucoma, this failure can be partially reversed by eliciting a controlled immune reaction in the eye. We show here that the chemokine SDF1 (stromal cell-derived factor 1) is an important contributor to this phenomenon. SDF1 is produced by infiltrative monocytes and acts through its cognate receptor to enhance RGC survival, promote optic nerve regeneration, and sensitize subtypes of RGCs that normally fail to respond to a complementary treatment to exhibit robust, long-distance regeneration. These findings establish SDF1 as an important therapeutic candidate for repairing the injured optic nerve.},
	keywords = {Axons, Chemokine CXCL12, Humans, Monocytes, Nerve Regeneration, Optic Nerve Injuries, PTEN Phosphohydrolase, Retinal Ganglion Cells},
	issn = {1091-6490},
	doi = {10.1073/pnas.2113751119},
	author = {Xie, Lili and Cen, Ling-Ping and Li, Yiqing and Gilbert, Hui-Ya and Strelko, Oleksandr and Berlinicke, Cynthia and Stavarache, Mihaela A and Ma, Madeline and Wang, Yongting and Cui, Qi and Kaplitt, Michael G and Zack, Donald J and Benowitz, Larry I and Yin, Yuqin}
}
