@article {1647895,
	title = {Long-term strabismus outcomes after unilateral infantile cataract surgery in the Infant Aphakia Treatment Study},
	journal = {J AAPOS},
	year = {2022},
	month = {2022 Jul 14},
	abstract = {PURPOSE: To characterize long-term strabismus outcomes in children in the Infant Aphakia Treatment Study (IATS). METHODS: This study was a secondary data analysis of long-term ocular alignment characteristics of children aged 10.5 years who had previously been enrolled in a randomized clinical trial evaluating aphakic management after unilateral cataract surgery between 1 and 6 months of age. RESULTS: In the IATS study, 96 of 109 children (88\%) developed strabismus through age 10.5 years. Half of the 20 children who were orthophoric at distance through age 5 years maintained orthophoria at distance fixation at 10.5 years. Esotropia was the most common type of strabismus prior to age 5 years (56/109 [51\%]), whereas exotropia (49/109 [45\%]) was the most common type of strabismus at 10.5 years (esotropia, 21\%; isolated hypertropia, 17\%). Strabismus surgery had been performed on 52 children (48\%), with 18 of these (35\%) achieving microtropia \&lt;10Δ. Strabismus was equally prevalent in children randomized to contact lens care compared with those randomized to primary intraocular lens implantation (45/54 [83\%] vs 45/55 [82\%]; P = 0.8). Median visual acuity in the study eye was 0.56 logMAR (20/72) for children with orthotropia or microtropia \&lt;10Δ versus 1.30 logMAR (20/400) for strabismus >=10Δ (P = 0.0003). CONCLUSIONS: Strabismus-in particular, exotropia-is common irrespective of aphakia management 10 years following infant monocular cataract surgery. The delayed emergence of exotropia with longer follow-up indicates a need for caution in managing early esotropia in these children. Children with better visual acuity at 10 years of age are more likely to have better ocular alignment.},
	issn = {1528-3933},
	doi = {10.1016/j.jaapos.2022.05.003},
	author = {Bothun, Erick D and Shainberg, Marla J and Christiansen, Stephen P and VanderVeen, Deborah K and Neely, Dan E and Kruger, Stacey J and Cotsonis, George and Lambert, Scott R and Infant Aphakic Treatment Study}
}
