@article {1653584,
	title = {The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts},
	journal = {Ophthalmology},
	volume = {129},
	number = {9},
	year = {2022},
	month = {2022 09},
	pages = {986-996},
	abstract = {PURPOSE: Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP). DESIGN: Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts. PARTICIPANTS: We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and\&nbsp;2009. METHODS: Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc). MAIN OUTCOME MEASURES: Corneal-compensated IOP. RESULTS: Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95\% confidence interval [CI], 0.06-0.11 mmHg; P \&lt; 0.001), 0.11 mmHg (95\% CI, 0.08-0.13 mmHg; P \&lt; 0.001), and 0.07 mmHg (95\% CI, 0.05-0.09 mmHg; P \&lt; 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95\% CI, 0.07-0.31 mmHg; P\&nbsp;= 0.001), 0.14 mmHg (95\% CI, 0.03-0.25 mmHg; P\&nbsp;= 0.016), and 0.17 mmHg (95\% CI, 0.06-0.29 mmHg; P\&nbsp;= 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (-0.05 mmHg; 95\% CI, -0.08 to -0.03; P\&nbsp;\&lt;\&nbsp;0.001) was not replicated in the EPIC-Norfolk cohort (P\&nbsp;= 0.30). CONCLUSIONS: Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature.},
	keywords = {Aged, Cholesterol, HDL, Cholesterol, LDL, Cross-Sectional Studies, Humans, Intraocular Pressure, Middle Aged, Prospective Studies, Risk Factors, Triglycerides, United Kingdom},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2022.04.023},
	author = {Madjedi, Kian M and Stuart, Kelsey V and Chua, Sharon Y L and Luben, Robert N and Warwick, Alasdair and Pasquale, Louis R and Kang, Jae H and Wiggs, Janey L and Lentjes, Marleen Ah and Aschard, Hugues and Sattar, Naveed and Foster, Paul J and Khawaja, Anthony P and Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium}
}
