@article {1653591,
	title = {Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria},
	journal = {Ocul Surf},
	volume = {26},
	year = {2022},
	month = {2022 Sep 18},
	pages = {200-208},
	abstract = {PURPOSE: To validate the international chronic ocular graft-versus-host disease (GVHD) diagnostic criteria (ICCGVHD) compared to the National Institute of Health diagnostic criteria 2014 (NIH2014) for chronic ocular GVHD. METHODS: Between 2013 and 2019, the study enrolled 233 patients with or without chronic ocular GVHD combined with the presence or absence of systemic chronic GVHD in an internationally prospective multicenter and observational cohort from 9 institutions. All patients were evaluated for four clinical parameters of ICCGVHD. RESULTS: The relation between the ICCGVHD score (0-11) and NIH2014 eye score (0-4) was relatively high (r\&nbsp;=\&nbsp;0.708, 95\% CI: 0.637-0.767, p\&nbsp;\&lt;\&nbsp;0.001). The sensitivity and specificity of ICCGVHD for NIH 2014 for 233 patients were 94.3\% (95\% CI: 89.6\%-98.1\%) and 71.7\% (95\% CI: 63.0-79.5\%), respectively (cutoff value of the ICCGVHD score\&nbsp;=\&nbsp;6). The positive predictive value was 77.1\% (95\% CI: 71.1\%-82.1\%), and the negative predictive value was 87.0\% (95\% CI:81.6-92.5\%). For the patients with systemic GVHD (n\&nbsp;=\&nbsp;171), the sensitivity and specificity were 94.2\% and 67.2\%, respectively (ICCGVHD-score cutoff value\&nbsp;=\&nbsp;6). By receiver operating characteristic (ROC) curve analysis, the area under the curve (AUC) was 0.903 (95\% CI: 0.859-0.948). For patients without systemic GVHD (n\&nbsp;=\&nbsp;62), the sensitivity and specificity were 100\% and 76.7\%, respectively (ICCGVHD-score cutoff value\&nbsp;=\&nbsp;6). The AUC was 0.891 (95\% CI 0.673-1.000). CONCLUSIONS: Good sensitivity, specificity, predictive value and correlation were found between ICCGVHD and NIH2014. ICCGVHD scores >=6 can be useful to diagnose ocular GVHD with or without systemic GVHD for clinical research.},
	issn = {1937-5913},
	doi = {10.1016/j.jtos.2022.09.002},
	author = {Ogawa, Yoko and Dana, Reza and Kim, Stella and Jain, Sandeep and Rosenblatt, Mark I and Perez, Victor L and Clayton, Janine A and Alves, Monica and Rocha, Eduardo Melani and Amparo, Francisco and Seo, Kyoung Yul and Wang, Yan and Shen, Joanne and Oh, Joo Youn and Vanathi, Murugesan and Nair, Sridevi and Na, Kyung-Sun and Riemens, Anjo and Sippel, Kimberly and Soifer, Matias and Wang, Shudan and Trindade, Marilia and Kim, Mee Kum and Yoon, Chang Ho and Yagi, Ryuichiro and Hiratsuka, Ryo and Ogawa, Mamoru and Shimizu, Eisuke and Sato, Yasunori and Pflugfelder, Stephen and Tsubota, Kazuo}
}
