@article {1653605,
	title = {Silicone Granulomas of the Eyelids-A Case Series Illustrating a Distant Migratory Phenomenon},
	journal = {Ophthalmic Plast Reconstr Surg},
	volume = {39},
	number = {1},
	year = {2023},
	month = {2023 Jan-Feb 01},
	pages = {81-87},
	abstract = {PURPOSE: Exogenous silicone has been reported to migrate to anatomic sights far from an initial injection or implantation site; this phenomenon has been rarely described in the ocular adnexa, especially in the eyelids. We document 3 additional cases of distant migration of silicone implanted elsewhere in the body to the eyelids and review the prior literature on this uncommon event. METHODS: A retrospective chart review of 3 patients was conducted along with analysis of diagnostic histopathology. A comprehensive review of the literature regarding dissemination or migration of silicone to the eyelids in patients with either silicone breast implants or silicone facial filler use was performed. RESULTS: Cases of silicone migrating to the eyelids from silicone breast implants and silicone-based facial filler are outlined in Tables 1 and 2, respectively. There are 4 total reports of women with silicone breast implants, including the 2 described here, with evidence of migration of silicone to the eyelid. Similarly, 5 cases of silicone-based facial filler with resultant migration of filler to the eyelids were identified, including 2 of the cases presented in this report (1 patient had both silicone breast implants and silicone facial filler). CONCLUSION: Silicone is chemically inert, but is known to travel throughout the body, causing a resultant foreign body response in tissue that can adversely affect even the eyelids. Silicone has a relatively characteristic histologic appearance and diagnosis of silicone granuloma highlights the importance of obtaining a thorough clinical history, particularly regarding prior cosmetic injections or breast enhancement surgery. Foreign material/foreign body granuloma is important to consider in patients with deep eyelid nodules of unclear etiology.},
	keywords = {Eyelids, Female, Granuloma, Foreign-Body, Humans, Prostheses and Implants, Retrospective Studies, Silicones},
	issn = {1537-2677},
	doi = {10.1097/IOP.0000000000002255},
	author = {Neerukonda, Vamsee K and Lefebvre, Daniel and Chatson, George P and Stagner, Anna M}
}
