@article {280836,
	title = {Proton Radiation Therapy for the Treatment of Retinoblastoma.},
	journal = {Int J Radiat Oncol Biol Phys},
	volume = {90},
	number = {4},
	year = {2014},
	month = {2014 Nov 15},
	pages = {863-9},
	abstract = {PURPOSE: To investigate long-term disease and toxicity outcomes for pediatric retinoblastoma patients treated with proton radiation therapy (PRT). METHODS AND MATERIALS: This is a retrospective analysis of 49 retinoblastoma patients (60 eyes) treated with PRT between 1986 and\&nbsp;2012. RESULTS: The majority (84\%) of patients had bilateral disease, and nearly half (45\%) had received prior chemotherapy. At a median follow-up of 8\&nbsp;years (range, 1-24\&nbsp;years), no patients died of retinoblastoma or developed metastatic disease. The post-PRT enucleation rate was low (18\%), especially in patients with early-stage disease (11\% for patients with International Classification for Intraocular Retinoblastoma [ICIR] stage A-B disease vs 23\% for patients with ICIR stage C-D disease). Post-PRT ophthalmologic follow-up was available for 61\% of the preserved eyes (30 of 49): 14 of 30 eyes (47\%) had 20/40 visual acuity or better, 7 of 30 (23\%) had moderate visual acuity (20/40-20/600), and 9 of 30 (30\%) had little or no useful vision (worse than 20/600). Twelve of 60 treated eyes (20\%) experienced a post-PRT event requiring intervention, with cataracts the most common (4 eyes). No patients developed an in-field second malignancy. CONCLUSIONS: Long-term follow-up of retinoblastoma patients treated with PRT demonstrates that PRT can achieve high local control rates, even in advanced cases, and many patients retain useful vision in the treated eye. Treatment-related ocular side effects were uncommon, and no radiation-associated malignancies were observed.},
	issn = {1879-355X},
	doi = {10.1016/j.ijrobp.2014.07.031},
	author = {Mouw, Kent W and Sethi, Roshan V and Yeap, Beow Y and MacDonald, Shannon M and Chen, Yen-Lin E and Tarbell, Nancy J and Yock, Torunn I and Munzenrider, John E and Adams, Judith and Grabowski, Eric and Mukai, Shizuo and Shih, Helen A}
}
