@article {303871,
	title = {Prosthetic replacement of the ocular surface ecosystem as treatment for ocular surface disease in patients with a history of stevens-johnson syndrome/toxic epidermal necrolysis.},
	journal = {Ophthalmology},
	volume = {122},
	number = {2},
	year = {2015},
	month = {2015 Feb},
	pages = {248-53},
	abstract = {PURPOSE: To report the visual outcomes of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in patients with ocular surface disease related to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). DESIGN: Retrospective cohort study. SUBJECTS: We included 86 patients (167 eyes) with history of SJS/TEN who underwent PROSE treatment from January 1, 2006, to January 1, 2011. METHODS: Etiology, previous interventions, change in visual acuity, change in visual function, and duration of follow-up are reported. Paired t test and Friedman test with Dunn{\textquoteright}s post hoc test for multiple comparisons were used for statistical analysis. MAIN OUTCOME MEASURES: Visual acuity at last follow-up and visual function based on the National Eye Institute 25-item Visual Functioning Questionnaire (NEI VFQ-25) at 6 months. RESULTS: We treated 35 males and 51 females with a history of SJS/TENS; median age was 36 years. The most common reported etiologies for SJS/TENS were antibiotics (n\&nbsp;= 25), ibuprofen (n\&nbsp;= 15), and lamotrigine (n\&nbsp;=\&nbsp;11). The median visual acuity at the initial visit was 20/60 (range, 20/400-20/25; 0.48 logarithm of the minimum angle of resolution [logMAR]), and the visual acuity at completion of customization was 20/25 (range, 20/200-20/20; 0.096 logMAR; P \&lt; 0.001), with no decline in median acuity at the end of follow-up. Median duration of follow-up was 16 months. There was a significant improvement in the visual function of the patients based on the NEI VFQ-25 questionnaire (mean of 48 points at baseline vs. mean of 72 points at 6 months; P\&nbsp;\&lt;\&nbsp;0.001). In addition, there was also an improvement in the self-reported general health of the patients (mean of 57 points at baseline vs. mean of 65 points at 6 months; P \&lt; 0.01). CONCLUSIONS: In a large cohort of patients with chronic ocular surface disease related to SJS/TEN, PROSE\&nbsp;treatment offers sustained and significant large improvement in visual function and acuity.},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2014.08.015},
	author = {Papakostas, Thanos D and Le, Hong-Gam and Chodosh, James and Jacobs, Deborah S}
}
