@article {303906, title = {Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.}, journal = {Nat Genet}, volume = {46}, number = {10}, year = {2014}, month = {2014 Oct}, pages = {1126-30}, abstract = {Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 {\texttimes} 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 {\texttimes} 10(-11) for rs2472493 near ABCA1 and P = 6.39 {\texttimes} 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 {\texttimes} 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.}, issn = {1546-1718}, doi = {10.1038/ng.3087}, author = {Hysi, Pirro G and Cheng, Ching-Yu and Springelkamp, Henri{\"e}t and Macgregor, Stuart and Bailey, Jessica N Cooke and Wojciechowski, Robert and Vitart, Veronique and Nag, Abhishek and Hewitt, Alex W and H{\"o}hn, Ren{\'e} and Venturini, Cristina and Mirshahi, Alireza and Ramdas, Wishal D and Thorleifsson, Gudmar and Vithana, Eranga and Khor, Chiea-Chuen and Stefansson, Arni B and Liao, Jiemin and Haines, Jonathan L and Amin, Najaf and Wang, Ya Xing and Wild, Philipp S and Ozel, Ayse B and Li, Jun Z and Fleck, Brian W and Zeller, Tanja and Staffieri, Sandra E and Teo, Yik-Ying and Cuellar-Partida, Gabriel and Luo, Xiaoyan and Allingham, R Rand and Richards, Julia E and Senft, Andrea and Karssen, Lennart C and Zheng, Yingfeng and Bellenguez, C{\'e}line and Xu, Liang and Iglesias, Adriana I and Wilson, James F and Kang, Jae H and van Leeuwen, Elisabeth M and Jonsson, Vesteinn and Thorsteinsdottir, Unnur and Despriet, Dominiek D G and Ennis, Sarah and Moroi, Sayoko E and Martin, Nicholas G and Jansonius, Nomdo M and Yazar, Seyhan and Tai, E-Shyong and Amouyel, Philippe and Kirwan, James and van Koolwijk, Leonieke M E and Hauser, Michael A and Jonasson, Fridbert and Leo, Paul and Loomis, Stephanie J and Fogarty, Rhys and Rivadeneira, Fernando and Kearns, Lisa and Lackner, Karl J and de Jong, Paulus T V M and Simpson, Claire L and Pennell, Craig E and Oostra, Ben A and Uitterlinden, Andr{\'e} G and Saw, Seang-Mei and Lotery, Andrew J and Bailey-Wilson, Joan E and Hofman, Albert and Vingerling, Johannes R and Maubaret, C{\'e}cilia and Pfeiffer, Norbert and Wolfs, Roger C W and Lemij, Hans G and Young, Terri L and Pasquale, Louis R and Delcourt, C{\'e}cile and Spector, Timothy D and Klaver, Caroline C W and Small, Kerrin S and Burdon, Kathryn P and Stefansson, Kari and Wong, Tien-Yin and BMES GWAS Group and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consortium 2 and Viswanathan, Ananth and Mackey, David A and Craig, Jamie E and Wiggs, Janey L and van Duijn, Cornelia M and Hammond, Christopher J and Aung, Tin} }