@article {303926, title = {Plakophilin-2 promotes activation of epidermal growth factor receptor.}, journal = {Mol Cell Biol}, volume = {34}, number = {20}, year = {2014}, month = {2014 Oct 15}, pages = {3778-9}, abstract = {While growth factor-driven dimerization of receptor tyrosine kinases (RTKs) is a simple and intuitive mechanism of activating RTKs, K.-I. Arimoto et al. (Mol. Cell. Biol. 34:3843-3854, 2014, doi:10.1128/MCB.00758-14) describe a novel means of promoting the activity of RTKs. Namely, plakophilin-2 (PKP2) associates with the epidermal growth factor receptor (EGFR) and enhances its ligand-dependent and ligand-independent activity. This discovery suggests that antagonizing PKP2 may be a new therapeutic opportunity to combat tumors in which activation of EGFR contributes to pathogenesis.}, issn = {1098-5549}, doi = {10.1128/MCB.00968-14}, author = {Kazlauskas, Andrius} }