@article {382431, title = {Retinoblastoma.}, journal = {Pediatr Clin North Am}, volume = {62}, number = {1}, year = {2015}, month = {2015 Feb}, pages = {201-23}, abstract = {Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3\% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2\ years of age and 95\% before 5\ years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, heritable form (25\% of all cases), characterized by the presence of germline mutations of the RB1 gene; and (2) a unilateral or unifocal form (75\% of all cases), 90\% of which are nonhereditary. The treatment of retinoblastoma is multidisciplinary and is designed primarily to save life and preserve vision.}, keywords = {Genes, Retinoblastoma, Humans, Mutation, Neoplasm Staging, Retinal Neoplasms, Retinoblastoma}, issn = {1557-8240}, doi = {10.1016/j.pcl.2014.09.014}, author = {Rodriguez-Galindo, Carlos and Orbach, Darren B and Vanderveen, Deborah} }