@article {382581,
	title = {Insulin-like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels.},
	journal = {J Biol Chem},
	volume = {290},
	number = {10},
	year = {2015},
	month = {2015 Mar 6},
	pages = {6349-60},
	abstract = {Here we report that VEGF-A and IGF-1 differ in their ability to stabilize newly formed blood vessels and endothelial cell tubes. Although VEGF-A failed to support an enduring vascular response, IGF-1 stabilized neovessels generated from primary endothelial cells derived from various vascular beds and mouse retinal explants. In these experimental systems, destabilization/regression was driven by lysophosphatidic acid (LPA). Because previous studies have established that Erk antagonizes LPA-mediated regression, we considered whether Erk was an essential component of IGF-dependent stabilization. Indeed, IGF-1 lost its ability to stabilize neovessels when the Erk pathway was inhibited pharmacologically. Furthermore, stabilization was associated with prolonged Erk activity. In the presence of IGF-1, Erk activity persisted longer than in the presence of VEGF or LPA alone. These studies reveal that VEGF and IGF-1 can have distinct inputs in the angiogenic process. In contrast to VEGF, IGF-1 stabilizes neovessels, which is dependent on Erk activity and associated with prolonged activation.},
	issn = {1083-351X},
	doi = {10.1074/jbc.M114.634154},
	author = {Jacobo, Sarah Melissa P and Kazlauskas, Andrius}
}
