@article {439641,
	title = {Vision-Related Quality of Life in Patients with Ocular Graft-versus-Host Disease.},
	journal = {Ophthalmology},
	volume = {122},
	number = {8},
	year = {2015},
	month = {2015 Aug},
	pages = {1669-74},
	abstract = {PURPOSE: To assess the vision-related quality of life (QOL) in a cohort of patients with ocular graft-versus-host disease (GVHD). DESIGN: Prospective study. PARTICIPANTS: Eighty-four patients diagnosed with chronic ocular GVHD. METHODS: We assessed the vision-related QOL with the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). The symptoms of ocular GVHD were assessed using the Ocular Surface Disease Index (OSDI) and Symptom Assessment in Dry Eye (SANDE) questionnaires. MAIN OUTCOME MEASURES: We assessed vision-related QOL with the NEI-VFQ-25 and compared the scores obtained from patients with ocular GVHD with those from a healthy population. In the ocular GVHD population, we also evaluated the associations between the NEI-VFQ-25 and the dry eye symptoms measured by the OSDI and SANDE questionnaires, age, duration of disease, best-corrected visual acuity (BCVA), corneal fluorescein staining (CFS), tear break-up time, and Schirmer test. RESULTS: The mean composite NEI-VFQ-25 score in patients with ocular GVHD was 76.5{\textpm}17. Compared with healthy subjects, patients with ocular GVHD reported reduced scores on all NEI-VFQ-25 subscales (each P \&lt; 0.001) with the exception of color vision (P\&nbsp;= 0.11). The NEI-VFQ-25 composite scores significantly correlated with OSDI (R\&nbsp;=\&nbsp;-0.81, P \&lt; 0.001), SANDE (R\&nbsp;=\&nbsp;-0.56, P \&lt; 0.001), CFS (R\&nbsp;=\&nbsp;-0.36, P\&nbsp;= 0.001), and BCVA (R\&nbsp;=\&nbsp;-0.30, P\&nbsp;= 0.004). CONCLUSIONS: Patients with ocular GVHD experience measurable impairment of vision-related QOL. This study highlights the impact of ocular GVHD on the vision-related QOL, and thus the importance of comprehensive diagnosis and treatment of this condition.},
	issn = {1549-4713},
	doi = {10.1016/j.ophtha.2015.04.011},
	author = {Saboo, Ujwala S and Amparo, Francisco and Abud, Tulio B and Schaumberg, Debra A and Dana, Reza}
}
