@article {439701,
	title = {Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration.},
	journal = {PLoS One},
	volume = {10},
	number = {5},
	year = {2015},
	month = {2015},
	pages = {e0125548},
	abstract = {We conducted a nested candidate gene study and pathway-based enrichment analysis on data from a multi-national 77,000-person project on the molecular genetics of age-related macular degeneration (AMD) to identify AMD-associated DNA-sequence variants in genes encoding constituents of a netrin-1 (NTN1)-based signaling pathway that converges on DNA-binding transcription complexes through a 3{\textquoteright}-5{\textquoteright}-cyclic adenosine monophosphate-calcineurin (cAMP-CN)-dependent axis. AMD-associated single nucleotide polymorphisms (SNPs) existed in 9 linkage disequilibrium-independent genomic regions; these included loci overlapping NTN1 (rs9899630, P <= 9.48 x 10-5), DCC (Deleted in Colorectal Cancer)-the gene encoding a primary NTN1 receptor (rs8097127, P <= 3.03 x 10-5), and 6 other netrin-related genes. Analysis of the NTN1-DCC pathway with exact methods demonstrated robust enrichment with AMD-associated SNPs (corrected P-value = 0.038), supporting the idea that processes driven by NTN1-DCC signaling systems operate in advanced AMD. The NTN1-DCC pathway contains targets of FDA-approved drugs and may offer promise for guiding applied clinical research on preventive and therapeutic interventions for AMD.},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0125548},
	author = {SanGiovanni, John Paul and Chen, Jing and Gupta, Ankur S and Smith, Lois E H and Sapieha, Przemyslaw and Lee, Phil H}
}
