@article {541251,
	title = {Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69.},
	journal = {Virology},
	volume = {485},
	year = {2015},
	month = {2015 Nov},
	pages = {452-9},
	abstract = {Viruses within human adenovirus species D (HAdV-D) infect epithelia at essentially every mucosal site. Hypervariable loops 1 and 2 of the hexon capsid protein contain epitopes that together form the epsilon determinant for serum neutralization. We report our analyses comparing HAdV-D15, 29, 56, and the recently identified type 69, each with highly similar hexons and the same serum neutralization profile, but otherwise disparate genomes. Of these, only HAdV-D type 56 is associated with epidemic keratoconjunctivitis (EKC), a severe infection of ocular surface epithelium and underlying corneal stroma. In the mouse adenovirus keratitis model, all four viruses induced inflammation. However, HAdV-D56 entry into human corneal epithelial cells and fibroblasts in vitro dramatically exceeded that of the other three viruses. We conclude that the hexon epsilon determinant is not a prime contributor to corneal tropism.},
	issn = {1096-0341},
	doi = {10.1016/j.virol.2015.08.018},
	author = {Singh, Gurdeep and Zhou, Xiaohong and Lee, Jeong Yoon and Yousuf, Mohammad A and Ramke, Mirja and Ismail, Ashrafali M and Lee, Ji Sun and Robinson, Christopher M and Seto, Donald and Dyer, David W and Jones, Morris S and Rajaiya, Jaya and Chodosh, James}
}
