@article {647356, title = {Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development.}, journal = {Acta Paediatr}, volume = {105}, number = {6}, year = {2016}, month = {2016 Jun}, pages = {576-86}, abstract = {UNLABELLED: Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities. CONCLUSION: There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.}, issn = {1651-2227}, doi = {10.1111/apa.13350}, author = {Hellstr{\"o}m, Ann and Ley, David and Hansen-Pupp, Ingrid and Hallberg, Boubou and L{\"o}fqvist, Chatarina and van Marter, Linda and van Weissenbruch, Mirjam and Ramenghi, Luca A and Beardsall, Kathryn and Dunger, David and H{\r a}rd, Anna-Lena and Smith, Lois E H} }