@article {742326,
	title = {Long-term visual outcomes of optic pathway gliomas in pediatric patients without neurofibromatosis type 1.},
	journal = {J Neurooncol},
	volume = {129},
	number = {1},
	year = {2016},
	month = {2016 Aug},
	pages = {173-8},
	abstract = {Sporadic optic pathway gliomas (OPGs) have been reported to cause more vision loss than OPGs associated with neurofibromatosis type-1, but long-term visual outcome data are limited. The purpose of this study was to report the visual outcomes of a cohort of pediatric patients with sporadic OPGs. This was a retrospective, cohort study at a tertiary care pediatric hospital and cancer institute. The study included all patients with sporadic OPGs evaluated from 1990 to 2014. The primary outcome was visual acuity at final follow-up. Secondary outcomes were risk factors for a poor visual outcome and the rate of progression. There were 59 pediatric patients included in the study. Median age at presentation was 2.5\&nbsp;years old and median follow-up was 5.2\&nbsp;years. In the worse eye at final follow-up, 16 patients (27 \%) were 20/30 or better, 9 patients (15 \%) were between 20/40 and 20/80, and 34 patients (58 \%) were 20/100 or worse. In the better eye at final follow-up, 33 patients (56 \%) were 20/30 or better, 11 patients (19 \%) were between 20/40 and 20/80, and 15 patients (25 \%) were 20/100 or worse. Risk factors for a poor visual outcome included younger age at presentation, optic nerve pallor, and tumor extent. Of the 54 patients (92 \%) who received treatment, 40 (74 \%) experienced disease progression during or after treatment. A majority of pediatric patients with sporadic OPGs had significant long-term visual impairment. In spite of treatment, tumor progression is common. Serial ophthalmic examinations with quantitative vision measurements are essential in the management of sporadic OPGs.},
	issn = {1573-7373},
	doi = {10.1007/s11060-016-2163-4},
	author = {Wan, Michael J and Ullrich, Nicole J and Manley, Peter E and Kieran, Mark W and Goumnerova, Liliana C and Heidary, Gena}
}
