@article {836986,
	title = {miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells.},
	journal = {PLoS One},
	volume = {11},
	number = {8},
	year = {2016},
	month = {2016},
	pages = {e0160887},
	abstract = {Oxidative stress has been shown to contribute to the development of age-related macular degeneration (AMD). MicroRNAs (miRNA) are small non-coding RNA molecules that function in RNA silencing and post-transcriptional regulation of gene expression. We showed miR-17-3p to be elevated in macular RPE cells from AMD patients and in ARPE-19 cells under oxidative stress. Transfection of miR-17-3p mimic in ARPE-19 induced cell death and exacerbated oxidative lethality that was alleviated by miR-17-3p inhibitor. The expression of antioxidant enzymes manganese superoxide dismutase (MnSOD) and thioredoxin reductase-2 (TrxR2) were suppressed by miR-17-3p mimic and reversed by miR-17-3p inhibitor. These results suggest miR-17-3p aggravates oxidative damage-induced cell death in human RPE cells, while miR-17-3p inhibitor acts as a potential protector against oxidative stress by regulating the expression of antioxidant enzymes.},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0160887},
	author = {Tian, Bo and Maidana, Daniel E and Dib, Bernard and Miller, John B and Bouzika, Peggy and Miller, Joan W and Vavvas, Demetrios G and Lin, Haijiang}
}
