@article {913531,
	title = {IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity.},
	journal = {J Immunol},
	volume = {197},
	number = {9},
	year = {2016},
	month = {2016 Nov 01},
	pages = {3464-3470},
	abstract = {Accumulating evidence shows that IL-17 is critically involved in diverse autoimmune diseases. However, its effect on the induction and progression of the humoral immune response is not fully understood. Using a preclinical model of IL-17-mediated dry eye disease, we demonstrate that upon encountering both the BCR and a secondary T cell signal, IL-17 can enhance B cell proliferation and germinal center formation in dry eye disease mice, suggesting that a stable Ag-dependent T-B cell interaction is required. Additionally, IL-17 also promotes the differentiation of B cells into isotype-switched B cells and plasma cells. Furthermore, we show that Th17 cells are more effective than Th1 cells to provide B cell help. Reduced B cell response correlates with significant reduction in clinical disease after in vivo IL-17A neutralization. In conclusion, our findings demonstrate a new role of IL-17 in promoting autoimmunity in part through directly enhancing B cell proliferation, differentiation, and plasma cell generation.},
	issn = {1550-6606},
	doi = {10.4049/jimmunol.1502641},
	author = {Subbarayal, Brinda and Chauhan, Sunil K and Di Zazzo, Antonio and Dana, Reza}
}
