@article {987946,
	title = {Nailfold capillary morphology in exfoliation syndrome},
	journal = {Eye (Lond)},
	volume = {31},
	number = {5},
	year = {2017},
	month = {2017 May},
	pages = {698-707},
	abstract = {PurposeThe purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary videomicroscopy.Patients and methodsWe used a JH-1004 capillaroscope to perform nailfold capillary videomicroscopy on the fourth and fifth digit of the non-dominant hand. We enrolled 56 XFS/XFG patients, 87 POAG patients, and 75 control subjects. Masked observers graded the videos for hemorrhages, avascular zones >=200 microns (μm), and degree of microvascular tortuosity on a four-point subjective scale. Multivariable odds ratios, 95\% confidence intervals and P-for trends for assessing the relation between morphological changes and POAG or XFS/XFG were obtained from logistic regression analyses. We also assessed this relation with XFS/XFG compared with POAG in multivariable models.ResultsAfter adjusting for multiple covariates, nailfold hemorrhages, avascular zones >=200 μm, and higher degree of vascular tortuosity were more common in XFS/XFG vs controls (P-for trend <=0.0001) and in POAG vs controls (P-for trend <=0.01). For each 100 capillaries, the number of hemorrhages was similar (P-for trend=0.91) between XFS/XFG and POAG patients; however, there were more avascular zones per 100 capillaries with borderline significance (P-for trend=0.04) in the XFS/XFG group. XFS/XFG patients had more tortuosity than POAG patients; specifically, having a tortuosity score >=1.5 was associated with a 4.4-fold increased odds of XFS/XFG (95\% confidence interval: 1.5-13.3) relative to a tortuosity score \&lt;1.0 (P-for trend=0.005).ConclusionA high degree of nailfold capillary tortuosity is a distinct non-ocular feature associated with XFS/XFG compared with either POAG or controls.},
	issn = {1476-5454},
	doi = {10.1038/eye.2016.312},
	author = {Cousins, C C and Kang, J H and Bovee, C and Wang, J. and Greenstein, S H and Turalba, A and Shen, L Q and Brauner, S and Boumenna, T and Blum, S and Levkovitch-Verbin, H and Ritch, R and Wiggs, J L and Knepper, P A and Pasquale, L. R.}
}
