%0 Journal Article %J Am J Ophthalmol %D 2017 %T Outcomes in Autoimmune Retinopathy Patients Treated With Rituximab %A Davoudi, Samaneh %A Ebrahimiadib, Nazanin %A Yasa, Cagla %A Sevgi, Damla D %A Roohipoor, Ramak %A Papavasilieou, Evangelia %A Comander, Jason %A Sobrin, Lucia %K Adult %K Aged %K Autoantibodies %K Autoimmune Diseases %K Electroretinography %K Female %K Humans %K Immunologic Factors %K Intravitreal Injections %K Male %K Middle Aged %K Ophthalmoscopy %K Outcome Assessment (Health Care) %K Retina %K Retinal Diseases %K Retrospective Studies %K Rituximab %K Tomography, Optical Coherence %K Visual Acuity %K Visual Fields %X PURPOSE: To evaluate clinical and ancillary testing, including adaptive optics, outcomes in autoimmune retinopathy (AIR) patients treated with rituximab. DESIGN: Retrospective, interventional case series. METHODS: patients: Sixteen AIR patients treated with rituximab. OBSERVATION PROCEDURES: All patients were treated with a loading and maintenance dose schedule of intravenous rituximab. Visual acuity (VA), electroretinography (ERG), and spectral-domain optical coherence tomography (SDOCT) and visual field (VF) results were recorded. A subset of patients was also imaged using adaptive optics scanning laser ophthalmoscopy (AO-SLO). MAIN OUTCOME MEASURES: Rates of VA change before vs after rituximab initiation were compared with mixed-model linear regression. RESULTS: The rate of visual decline was significantly less after rituximab initiation compared with the rate of visual decline prior to rituximab initiation (P = .005). Seventy-seven percent of eyes had stable or improved VA 6 months after rituximab initiation. Amplitudes and implicit times on ERG, mean deviation on VF, central subfield mean thickness, and total macular volume did not decrease to a significant degree over the rituximab treatment period. Six eyes had serial AO-SLO imaging. Cone densities did not change significantly over the treatment period. CONCLUSION: VA was stable or improved in a majority of AIR patients while they were being treated with rituximab. OCT and ERG parameters, as well as AO-SLO cone densities, were stable during treatment. Studies with additional patients and longer follow-up periods are needed to further explore the utility of rituximab in the management of AIR. %B Am J Ophthalmol %V 180 %P 124-132 %8 2017 Aug %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/28483493?dopt=Abstract %R 10.1016/j.ajo.2017.04.019