%0 Journal Article %J Cell Death Dis %D 2014 %T Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment %A Matsumoto, H %A Murakami, Y %A Kataoka, K %A Lin, H %A Connor, K M %A Miller, J W %A Zhou, D %A Avruch, J %A Vavvas, D G %K Animals %K Apoptosis %K Caspase 3 %K Mice %K Mice, Knockout %K Photoreceptor Cells, Vertebrate %K Protein-Serine-Threonine Kinases %K Retinal Detachment %K Tumor Suppressor Protein p53 %X Photoreceptor cell death is the definitive cause of vision loss in retinal detachment (RD). Mammalian STE20-like kinase (MST) is a master regulator of both cell death and proliferation and a critical factor in development and tumorigenesis. However, to date the role of MST in neurodegeneration has not been fully explored. Utilizing MST1(-/-) and MST2(-/-) mice we identified MST2, but not MST1, as a regulator of photoreceptor cell death in a mouse model of RD. MST2(-/-) mice demonstrated significantly decreased photoreceptor cell death and outer nuclear layer (ONL) thinning after RD. Additionally, caspase-3 activation was attenuated in MST2(-/-) mice compared to control mice after RD. The transcription of p53 upregulated modulator of apoptosis (PUMA) and Fas was also reduced in MST2(-/-) mice post-RD. Retinas of MST2(-/-) mice displayed suppressed nuclear relocalization of phosphorylated YAP after RD. Consistent with the reduction of photoreceptor cell death, MST2(-/-) mice showed decreased levels of proinflammatory cytokines such as monocyte chemoattractant protein 1 and interleukin 6 as well as attenuated inflammatory CD11b cell infiltration during the early phase of RD. These results identify MST2, not MST1, as a critical regulator of caspase-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target. %B Cell Death Dis %V 5 %P e1269 %8 2014 May 29 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/24874741?dopt=Abstract %R 10.1038/cddis.2014.218