%0 Journal Article %J BMC Res Notes %D 2012 %T Oral acetazolamide after Boston keratoprosthesis in Stevens-Johnson syndrome %A Kumar, Radhika %A Dohlman, Claes H %A Chodosh, James %K Acetazolamide %K Administration, Oral %K Adolescent %K Adult %K Boston %K Carbonic Anhydrase Inhibitors %K Cornea %K Female %K Glaucoma %K Humans %K Intraocular Pressure %K Male %K Middle Aged %K Polymethyl Methacrylate %K Prostheses and Implants %K Retrospective Studies %K Stevens-Johnson Syndrome %K Titanium %X BACKGROUND: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure. FINDINGS: Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction. CONCLUSION: Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela. %B BMC Res Notes %V 5 %P 205 %8 2012 Apr 30 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/22546532?dopt=Abstract %R 10.1186/1756-0500-5-205