%0 Journal Article %J Am J Ophthalmol %D 2020 %T Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors %A Shah, Deepika N %A Al-Moujahed, Ahmad %A Newcomb, Craig W %A KaƧmaz, R Oktay %A Daniel, Ebenezer %A Thorne, Jennifer E %A Foster, C Stephen %A Jabs, Douglas A %A Levy-Clarke, Grace A %A Nussenblatt, Robert B %A Rosenbaum, James T %A Sen, H Nida %A Suhler, Eric B %A Bhatt, Nirali P %A Kempen, John H %A Systemic Immunosuppressive Therapy for Eye Diseases Research Group %X PURPOSE: This study evaluated the risk and risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases. DESIGN: Retrospective cohort study. METHODS: Patients with noninfectious ocular inflammation had been followed longitudinally between 1978 and 2007 at 4 US subspecialty uveitis centers. The main outcome measurements were occurrences of ERD and predictive factors. RESULTS: A total of 176 of 14,612 eyes with ocular inflammation presented with ERD. Among uveitis cases, Vogt-Koyanagi-Harada syndrome (VKH) (odds ratio [OR] = 109), undifferentiated choroiditis (OR = 9.18), sympathetic ophthalmia (OR = 8.43), primary or secondary panuveitis (OR = 7.09), multifocal choroiditis with panuveitis (OR = 4.51), and "other" forms of posterior uveitis (OR = 16.9) were associated with a higher prevalence of ERD. Among the 9,209 uveitic or scleritic eyes initially free of ERD and followed, 137 incident ERD cases were observed over 28,949 eye-years at risk (incidence rate = 0.47% [0.40%-0.56%/eye-year]). VKH (HR = 13.2), sympathetic ophthalmia (HR = 5.82), undifferentiated choroiditis (HR = 6.03), primary or secondary panuveitis (HR = 4.21), and rheumatoid arthritis (HR = 3.30) were significantly associated with incident ERD. A significant dose-response relationship with the prevalence and incidence of ERD were observed for AC cells and vitreous cell activity. African Americans had significantly higher prevalence and incidence of ERD. CONCLUSIONS: Other ocular inflammatory conditions in addition to VKH syndrome and posterior scleritis were associated with increased risk of ERD, indicating that ERD does not necessarily dictate a diagnosis of VKH or posterior scleritis. In addition, the relationship between ERD and inflammatory severity factors implies that inflammation is a key predictive factor associated with developing ERD and requires early and vigorous control. %B Am J Ophthalmol %V 218 %P 279-287 %8 2020 Oct %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/32621891?dopt=Abstract %R 10.1016/j.ajo.2020.06.019