%0 Journal Article %J Ocul Immunol Inflamm %D 2020 %T The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population %A Testi, Ilaria %A Agrawal, Rupesh %A Mahajan, Sarakshi %A Agarwal, Aniruddha %A Gunasekeran, Dinesh Visva %A Raje, Dhananjay %A Aggarwal, Kanika %A Murthy, Somasheila I %A Westcott, Mark %A Chee, Soon-Phaik %A McCluskey, Peter %A Ho, Su Ling %A Teoh, Stephen %A Cimino, Luca %A Biswas, Jyotirmay %A Narain, Shishir %A Agarwal, Manisha %A Mahendradas, Padmamalini %A Khairallah, Moncef %A Jones, Nicholas %A Tugal-Tutkun, Ilknur %A Babu, Kalpana %A Basu, Soumayava %A Carreño, Ester %A Lee, Richard %A Al-Dhibi, Hassan %A Bodaghi, Bahram %A Invernizzi, Alessandro %A Goldstein, Debra A %A Herbort, Carl P %A Barisani-Asenbauer, Talin %A González-López, Julio J %A Androudi, Sofia %A Bansal, Reema %A Moharana, Bruttendu %A Esposti, Simona Degli %A Tasiopoulou, Anastasia %A Nadarajah, Sengal %A Agarwal, Mamta %A Abraham, Sharanaya %A Vala, Ruchi %A Singh, Ramandeep %A Sharma, Aman %A Sharma, Kusum %A Zierhut, Manfred %A Kon, Onn Min %A Cunningham, Emmett T %A Kempen, John H %A Nguyen, Quan Dong %A Pavesio, Carlos %A Gupta, Vishali %X PURPOSE: To examine disease profile of tubercular uveitis (TBU) in Paediatric population. METHODS: Among 945 patients of the retrospective multinational study by the Collaborative Ocular Tuberculosis Study (COTS)-1, 29 Paediatric patients diagnosed with TBU were analyzed. RESULTS: Mean age of disease presentation was 12.8 (range 4-18 years), with predominance of males (n = 14/20; 70.0%) and Asian ethnicity (n = 25/29; 86.2%). Posterior uveitis (n = 14/28; 50%) was the most frequent uveitis phenotype, with choroidal involvement occurring in 64.7% (n = 11/17). Incidence of optic disc edema and macular edema was higher in children (n = 8/18; 44.4% and n = 5/18; 27.8%, respectively) than in adults (n = 160/942; 16.9% and n = 135/942; 14.3%, respectively). Comparison of optic disc edema between subgroups showed a significant difference (). All patients received oral corticosteroids, most of them with antitubercular therapy. Treatment failure developed in 4.8% (n = 1/21). CONCLUSIONS: Children have a more severe inflammatory response to the disease, and an intensive anti-inflammatory therapeutic regimen is required to achieve a positive treatment outcome. %B Ocul Immunol Inflamm %P 1-7 %8 2020 Aug 17 %G eng %1 http://www.ncbi.nlm.nih.gov/pubmed/32804578?dopt=Abstract %R 10.1080/09273948.2020.1781197