%0 Journal Article %J J Cell Mol Med %D 2021 %T Chalcomoracin prevents vitreous-induced activation of AKT and migration of retinal pigment epithelial cells %A Han, Haote %A Yang, Yanhui %A Liu, Bing %A Tian, Jingkui %A Dong, Lijun %A Qi, Hui %A Zhu, Wei %A Wang, Jiantao %A Lei, Hetian %X Retinal pigment epithelial (RPE) cells are the major cell type in the epi- or sub-retinal membranes in the pathogenesis of proliferative vitreoretinopathy (PVR), which is a blinding fibrotic eye disease and still short of effective medicine. The purpose of this study is to demonstrate whether Chalocomoracin (CMR), a novel purified compound from fungus-infected mulberry leaves, is able to inhibit vitreous-induced signalling events and cellular responses intrinsic to PVR. Our studies have revealed that the CMR IC50 for ARPE-19 cells is 35.5 μmol/L at 72 hours, and that 5 μmol/L CMR inhibits vitreous-induced Akt activation and p53 suppression; in addition, we have discovered that this chemical effectively blocks vitreous-stimulated proliferation, migration and contraction of ARPE-19 cells, suggesting that CMR is a promising PVR prophylactic. %B J Cell Mol Med %V 25 %P 9102-9111 %8 2021 Oct %G eng %N 19 %1 http://www.ncbi.nlm.nih.gov/pubmed/34432370?dopt=Abstract %R 10.1111/jcmm.16590