%0 Journal Article %J Graefes Arch Clin Exp Ophthalmol %D 2023 %T Structure-function association between contrast sensitivity and retinal thickness (total, regional, and individual retinal layer) in patients with idiopathic epiretinal membrane %A Zeng, Rebecca %A Vingopoulos, Filippos %A Wang, Mengyu %A Bannerman, Augustine %A Wescott, Hannah E %A Baldwin, Grace %A Katz, Raviv %A Koch, Thomas %A Tobias Elze %A Kim, Leo A %A Vavvas, Demetrios G %A Husain, Deeba %A Miller, John B %K Contrast Sensitivity %K Cross-Sectional Studies %K Epiretinal Membrane %K Humans %K Retina %K Retrospective Studies %X PURPOSE: To investigate structure-function associations between retinal thickness, visual acuity (VA), and contrast sensitivity (CS), using the quantitative contrast sensitivity function (qCSF) method in patients with idiopathic epiretinal membrane (ERM). METHODS: Retrospective, cross-sectional observational study. Patients with a diagnosis of idiopathic ERM were included. Patients underwent complete ophthalmic examination, spectral-domain optical coherence tomography imaging (SD-OCT) (SPECTRALIS® Heidelberg), and CS testing using the qCSF method. Outcomes included area under the log CSF (AULCSF), contrast acuity (CA), and CS thresholds at 1, 1.5, 3, 6, 12, and 18 cycles per degree (cpd). RESULTS: A total of 102 eyes of 79 patients were included. Comparing standardized regression coefficients, retinal thickness in most ETDRS sectors was associated with larger reductions in AULCSF, CA, and CS thresholds at 3 and 6 cpd than those in logMAR VA. These differences in effect on VA and CS metrics were more pronounced in the central subfield and inner ETDRS sectors. Among the retinal layers, increased INL thickness had the most detrimental effect on visual function, being significantly associated with reductions in logMAR VA, AULCSF, CA, and CS thresholds at 3 and 6 cpd (all p < .01), as well as at 1.5 and 12 cpd (p < .05). CONCLUSION: Retinal thickness seems to be associated with larger reductions in contrast sensitivity than VA in patients with ERM. Measured with the qCSF method, contrast sensitivity may serve as a valuable adjunct visual function metric for patients with ERM. %B Graefes Arch Clin Exp Ophthalmol %V 261 %P 631-639 %8 2023 Mar %G eng %N 3 %1 http://www.ncbi.nlm.nih.gov/pubmed/36149494?dopt=Abstract %R 10.1007/s00417-022-05819-y