%0 Journal Article %J Mol Cell Biol %D 2014 %T Plakophilin-2 promotes activation of epidermal growth factor receptor. %A Kazlauskas, Andrius %X

While growth factor-driven dimerization of receptor tyrosine kinases (RTKs) is a simple and intuitive mechanism of activating RTKs, K.-I. Arimoto et al. (Mol. Cell. Biol. 34:3843-3854, 2014, doi:10.1128/MCB.00758-14) describe a novel means of promoting the activity of RTKs. Namely, plakophilin-2 (PKP2) associates with the epidermal growth factor receptor (EGFR) and enhances its ligand-dependent and ligand-independent activity. This discovery suggests that antagonizing PKP2 may be a new therapeutic opportunity to combat tumors in which activation of EGFR contributes to pathogenesis.

%B Mol Cell Biol %V 34 %P 3778-9 %8 2014 Oct 15 %G eng %N 20 %1 http://www.ncbi.nlm.nih.gov/pubmed/25113561?dopt=Abstract %R 10.1128/MCB.00968-14