Tacrolimus Optic Neuropathy

Citation:

Rasool N, Boudreault K, Lessell S, Prasad S, Cestari DM. Tacrolimus Optic Neuropathy. J Neuroophthalmol 2018;38(2):160-166.

Date Published:

2018 Jun

Abstract:

BACKGROUND: Tacrolimus (FK506, Prograf) is a potent immunosuppressant, which inhibits cytokine synthesis and blocks T-cell development. Optic neuropathy from tacrolimus toxicity is very uncommon but, when present, can result in severe vision loss. METHODS: Case series and review of the literature. RESULTS: We present 3 patients with tacrolimus optic neuropathy after bone marrow transplantation complicated by graft-vs-host disease and demonstrate the differing clinical and radiologic presentation of this presumed toxic optic neuropathy. CONCLUSIONS: Tacrolimus optic neuropathy can manifest in a multitude of clinical presentations and can have devastating visual consequences.

Last updated on 07/02/2018