29605814 2018 04 01

1468-2079 2018 Mar 31 Br J Ophthalmol Evaluation of choroidal lesions with swept-source optical coherence tomography. bjophthalmol-2017-311586 10.1136/bjophthalmol-2017-311586 The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation. This was a prospective, cross-sectional study. Patients with choroidal melanocytic lesions <3 mm in thickness on B-scan ultrasonography were recruited. All participants underwent SS-OCT. On SS-OCT we evaluated qualitative (eg, lesion outline, detection of scleral-choroidal interface and quality of the image) and quantitative (measurement of maximum lesion thickness and the largest basal diameter) parameters. Probability of optimal image quality was examined using ordered logistic regression models. The main outcome measure was quality of the choroidal lesion images on SS-OCT, defined as: optimal, suboptimal or poor. We included 85 choroidal lesions of 82 patients. There were 24 choroidal lesions (29%) for which image quality was classified as optimal, 31 lesions (37%) as suboptimal and 30 lesions (36%) as poor. The factors associated with optimal image quality were distance closer to the fovea (OR 0.76, p<0.001), posterior pole location (OR 3.87, p=0.05), lower ultrasonography thickness (OR 0.44, p=0.04), lighter lesion pigmentation (OR 0.12, p=0.003) and smaller lesion diameter (OR 0.73, p<0.001). In the multivariable analysis, closer distance to the fovea (OR 0.81, p=0.005), lighter lesion pigmentation (OR 0.11, p=0.01) and smaller lesion diameter (OR 0.76, p=0.006) remained statistically significant. SS-OCT is useful in imaging most choroidal melanocytic lesions. Image quality is best when the choroidal lesion is closer to the fovea, has a smaller diameter and a lighter choroidal pigmentation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Ung Cindy C Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Laíns Inês I Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Silverman Rebecca F RF http://orcid.org/0000-0001-6313-1153 Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Woods Russell R Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts, USA. Lane Anne Marie AM Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Papakostas Thanos D TD Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Husain Deeba D Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Miller Joan W JW Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Gragoudas Evangelos S ES Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Kim Ivana K IK Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Miller John B JB Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. eng Journal Article 2018 03 31

England Br J Ophthalmol 0421041 0007-1161 choroid imaging neoplasia retina Competing interests: IL receives travel expenses from Allergan. IKK: Consultant to Allergan, Alcon, Genentech and Iconic Therapeutics. JWM: Consultant to Alcon Research Institute, KalVista Pharmaceuticals Ltd, Maculogix Inc; Patent with ONL Therapeutics LLC, Royalties from Valeant Pharmaceuticals. JBM: Consultant to Allergan. The following authors have no financial disclosures: CU, RFS, RW, AML, TDP, DH, ESG. 2017 11 15 2018 03 11 2018 4 2 6 0 2018 4 2 6 0 2018 4 2 6 0 aheadofprint 29605814 bjophthalmol-2017-311586 10.1136/bjophthalmol-2017-311586 29602567 2018 03 31

1549-4713 2018 Mar 27 Ophthalmology Determinants of Outcomes of Adenoviral Keratoconjunctivitis. S0161-6420(17)32895-6 10.1016/j.ophtha.2018.02.016 To determine host and pathogen factors predictive of outcomes in a large clinical cohort with keratoconjunctivitis. Retrospective analyses of the clinical and molecular data from a randomized, controlled, masked trial for auricloscene for keratoconjunctivitis (NVC-422 phase IIB, NovaBay; clinicaltrials.gov identifier, NCT01877694). Five hundred participants from United States, India, Brazil, and Sri Lanka with clinical diagnosis of keratoconjunctivitis and positive rapid test results for adenovirus. Clinical signs and symptoms and bilateral conjunctival swabs were obtained on days 1, 3, 6, 11, and 18. Polymerase chain reaction (PCR) analysis was performed to detect and quantify adenovirus in all samples. Regression models were used to evaluate the association of various variables with keratoconjunctivitis outcomes. Time to resolution of each symptom or sign was assessed by adenoviral species with Cox regression. The difference in composite scores of clinical signs between days 1 and 18, mean visual acuity change between days 1 and 18, and time to resolution of each symptom or sign. Of 500 participants, 390 (78%) showed evidence of adenovirus by PCR. Among adenovirus-positive participants, adenovirus D species was most common (63% of total cases), but a total of 4 species and 21 different types of adenovirus were detected. Adenovirus D was associated with more severe signs and symptoms, a higher rate of subepithelial infiltrate development, and a slower decline in viral load compared with all other adenovirus species. The clinical courses of all patients with non-adenovirus D species infection and adenovirus-negative keratoconjunctivitis were similar. Mean change in visual acuity between days 1 and 18 was a gain of 1.9 letters; worse visual outcome was associated with older age. A substantial proportion of keratoconjunctivitis is not associated with a detectable adenovirus. The clinical course of those with adenovirus D keratoconjunctivitis is significantly more severe than those with non-adenovirus D species infections or adenovirus-negative keratoconjunctivitis; high viral load at presentation and non-United States origin of participants is associated with poorer clinical outcome. Copyright © 2018 American Academy of Ophthalmology. All rights reserved. Lee Cecilia S CS Department of Ophthalmology, University of Washington, Seattle, Washington. Electronic address: leecs2@uw.edu. Lee Aaron Y AY Department of Ophthalmology, University of Washington, Seattle, Washington. Akileswaran Lakshmi L Department of Ophthalmology, University of Washington, Seattle, Washington. Stroman David D NovaBay Pharmaceuticals, Inc., Emeryville, California. Najafi-Tagol Kathryn K NovaBay Pharmaceuticals, Inc., Emeryville, California. Kleiboeker Steve S Viracor Eurofins Clinical Diagnostics, Lee's Summit, Missouri. Chodosh James J Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Magaret Amalia A Department of Biostatistics, University of Washington, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Wald Anna A Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington. Van Gelder Russell N RN Department of Ophthalmology, University of Washington, Seattle, Washington; Departments of Biological Structure and Pathology, University of Washington, Seattle, Washington. BAYnovation Study Group eng ClinicalTrials.gov NCT01877694 Journal Article 2018 03 27

United States Ophthalmology 7802443 0161-6420 Bonini Stefano S Lambiase Alessandro A Rama Paolo P Messmer Elisabeth E Aragona Pasquale P Geerling Gerd G Mastropasqua Leonardo L Mencucci Rita R Dart John J Leonardi Andrea A Montero Jesus J Rolando Maurizio M Reinhard Thomas T Cursiefen Claus C Etxebarria Jaime J Gabison Eric E Szaflik Jacek P JP Borderie Vincent V De La Paz Maria M Sainz de la Maza Maite M Wylegala Edward E Figueiredo Francisco F Fogagnolo Paolo P Hossain Parwez P Lorenz Katrin K Robert Pierre-Yves PY Benitez Del Castillo José J Creuzot-Garcher Catherine C Kruse Friedrich F Malecaze François F Merayo-Lloves Jesús J Rauz Saaeha S Alio Jorge J Carley Fiona F Kanna Ramaesh R Koppen Carina C Nemeth Janos J Murta Joaquim Neto JN Torrao Luis L 2017 09 20 2018 02 07 2018 02 12 2018 4 1 6 0 2018 4 1 6 0 2018 4 1 6 0 aheadofprint 29602567 S0161-6420(17)32895-6 10.1016/j.ophtha.2018.02.016 29599383 2018 03 30

1757-790X 2018 2018 Mar 28 BMJ Case Rep Ethics of a therapeutic trial: addressing limitations of an active intervention in optic nerve lymphoma. bcr-2018-224217 10.1136/bcr-2018-224217 We report a unique case of optic nerve lymphoma after completion of chemotherapy for non-Hodgkin's lymphoma. The uncommon nature of presentation, our therapeutic dilemma and the further course of treatment are reported. In cases with extremely poor prognosis, unnecessary treatment puts additional strain both financially and psychologically on the patients and their family. Therapeutic focus should be on hospice care and family counselling. The decision to not treat is a crucial component of cancer management; however, the ethics of this decision are yet to be suitably addressed by the literature. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Singh Rohan Bir RB http://orcid.org/0000-0002-2426-3900 Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India. Thakur Sahil S Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India. Ichhpujani Parul P Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India. Kumar Suresh S Department of Ophthalmology, Government Medical College and Hospital, Chandigarh, Punjab, India. eng Journal Article 2018 03 28

England BMJ Case Rep 101526291 1757-790X chemotherapy ethics ophthalmology radiotherapy visual pathway Competing interests: None declared. 2018 3 31 6 0 2018 3 31 6 0 2018 3 31 6 0 epublish 29599383 bcr-2018-224217 10.1136/bcr-2018-224217 29595569 2018 03 29

1539-2864 2018 Mar 27 Retina (Philadelphia, Pa.) SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS AND VISUAL OUTCOME AFTER TREATMENT FOR VITREOMACULAR TRACTION. 10.1097/IAE.0000000000002116 To evaluate the capacity of spectral domain optical coherence tomography macular findings to predict best-corrected visual acuity (BCVA) outcomes after treatment for symptomatic vitreomacular traction. This consecutive, retrospective study included 24 patients (29 eyes) who experienced vitreomacular traction release with pneumatic vitreolysis (n = 9), intravitreal ocriplasmin (n = 6), or pars plana vitrectomy (n = 14). Preoperative and postoperative spectral domain optical coherence tomography images were used to determine the cone outer segment tips (COST) line, inner segment/outer segment line, and other frequently used features. Correlations between optical coherence tomography findings and BCVA were determined using regression analyses. Postoperative BCVA was correlated with length of the COST line and inner segment/outer segment line defects at 1, 3, 6, and 12 months postoperatively (P < 0.05) by simple linear regression analysis. However, multivariable regression analysis showed that only length of the COST line defect was significantly correlated with BCVA preoperatively and postoperatively (P < 0.05). Postoperative BCVA improvement at 12 months was significantly correlated with preoperative length of the COST line defect (P < 0.01). Recovery of the COST line and inner segment/outer segment line defects as observed by spectral domain optical coherence tomography is positively correlated with visual acuity improvement after successful vitreomacular traction treatment. Best-corrected visual acuity improvement may be predicted using the length of the preoperative COST line defect. Sun Peng P Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Department of Ophthalmology, First Hospital of China Medical University, Shenyang, People's Republic of China. Tandias Rachel M RM Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Yu Gina G Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Arroyo Jorge G JG Division of Ophthalmology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. eng Journal Article 2018 03 27

United States Retina 8309919 0275-004X 2018 3 30 6 0 2018 3 30 6 0 2018 3 30 6 0 aheadofprint 29595569 10.1097/IAE.0000000000002116 29572107 2018 03 24

1879-1891 2018 Mar 20 Am. J. Ophthalmol. Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated with Graft-versus-host Disease. S0002-9394(18)30125-9 10.1016/j.ajo.2018.03.024 To compare the response of dry eye disease (DED) to treatment with topical steroid in patients with and without graft-versus-host disease (GVHD). Post-hoc analysis of a double-masked, randomized clinical trial. This single-center study included 42 patients with moderate to severe DED associated with (N=21) or without (N=21) chronic GVHD. In each group, patients received either loteprednol etabonate 0.5% ophthalmic suspension or artificial tears twice daily for 4 weeks. Clinical data, including Ocular Surface Disease Index (OSDI) questionnaire, corneal fluorescein staining (CFS), conjunctival lissamine green staining, tear break-up time (TBUT), and Schirmer's test, were evaluated before and after treatment. There were no significant differences in signs and symptoms of DED between the groups at baseline. In non-GVHD patients receiving loteprednol treatment, the average OSDI score decreased by 34% from 49.5 ± 5.9 to 32.6 ± 4.8 (Mean±SEM, P=0.001) and the average CFS score decreased by 41% from 5.6 ± 0.6 to 3.3 ± 0.9 (P=0.02). On the other hand, loteprednol treatment in GVHD patients resulted in minimal change in OSDI (59.2±6.7 to 61.1±7.1, 3% increase, P=0.66) and CFS (5.5±0.5 to 5.3±1.1, 4% decrease, P=0.85) scores. Treatment with artificial tears resulted in 22% decrease of OSDI (P=0.10) and 32% decrease of CFS (P=0.02) scores in non-GVHD patients, and had minimal effect in patients with GVHD. DED patient with ocular GVHD have a less favorable response to a low-dose topical steroid regimen compared with those without ocular GVHD even with similar baseline disease severity. Copyright © 2018 Elsevier Inc. All rights reserved. Yin Jia J Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Kheirkhah Ahmad A Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Dohlman Thomas T Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Saboo Ujwala U Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Dana Reza R Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address: Reza_Dana@meei.harvard.edu. eng Journal Article 2018 03 20

United States Am J Ophthalmol 0370500 0002-9394 2017 12 08 2018 02 21 2018 03 11 2018 3 25 6 0 2018 3 25 6 0 2018 3 25 6 0 aheadofprint 29572107 S0002-9394(18)30125-9 10.1016/j.ajo.2018.03.024 29566793 2018 03 27

1097-4199 97 6 2018 Mar 21 Neuron Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. 1268-1283.e6 S0896-6273(18)30148-X 10.1016/j.neuron.2018.02.027 To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS. Copyright © 2018 Elsevier Inc. All rights reserved. Nicolas Aude A Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Kenna Kevin P KP Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Renton Alan E AE Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Ticozzi Nicola N Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center - Università degli Studi di Milano, Milan 20122, Italy. Faghri Faraz F Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Chia Ruth R Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Dominov Janice A JA Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Kenna Brendan J BJ Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Nalls Mike A MA Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Data Tecnica International, Glen Echo, MD, USA. Keagle Pamela P Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Rivera Alberto M AM Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. van Rheenen Wouter W Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Murphy Natalie A NA Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. van Vugt Joke J F A JJFA Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Geiger Joshua T JT Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA. Van der Spek Rick A RA Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Pliner Hannah A HA Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Shankaracharya Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Smith Bradley N BN Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Marangi Giuseppe G Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Institute of Genomic Medicine, Catholic University, Roma, Italy. Topp Simon D SD Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Abramzon Yevgeniya Y Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Sobell Department of Motor Neuroscience and Movement Disorders, University College London, Institute of Neurology, London, UK. Gkazi Athina Soragia AS Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Eicher John D JD Genetics and Pharmacogenomics, MRL, Merck & Co., Inc., Boston, MA 02115, USA. Kenna Aoife A Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. ITALSGEN Consortium Mora Gabriele G ALS Center, Salvatore Maugeri Foundation, IRCCS, Mistretta, Messina, Italy. Calvo Andrea A "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy. Mazzini Letizia L "Maggiore della Carità" University Hospital, Novara, Italy. Riva Nilo N Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy. Mandrioli Jessica J Department of Neuroscience, St. Agostino Estense Hospital, Azienda Ospedaliero Universitaria di Modena, Modena, Italy. Caponnetto Claudia C Department of Neurosciences, Ophthalmology, Genetics, Rehabilitation, Maternal and Child Health, Ospedale Policlinico San Martino, Genoa, Italy. Battistini Stefania S Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. Volanti Paolo P ALS Center, Salvatore Maugeri Foundation, IRCCS, Mistretta, Messina, Italy. La Bella Vincenzo V ALS Clinical Research Center, University of Palermo, Palermo, Italy. Conforti Francesca L FL Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy. Borghero Giuseppe G Department of Neurology, Azienda Universitario Ospedaliera di Cagliari and University of Cagliari, Cagliari, Italy. Messina Sonia S Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center for Neuromuscular Diseases, Aurora Foundation, Messina, Italy. Simone Isabella L IL Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy. Trojsi Francesca F Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy. Salvi Fabrizio F "Il Bene" Center for Immunological and Rare Neurological Diseases at Bellaria Hospital, IRCCS, Istituto delle Scienze Neurologiche, Bologna, Italy. Logullo Francesco O FO Neurological Clinic, Marche Polytechnic University, Ancona, Italy. D'Alfonso Sandra S Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. Corrado Lucia L Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. Capasso Margherita M Department of Neurology, University of Chieti, Chieti, Italy. Ferrucci Luigi L Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Genomic Translation for ALS Care (GTAC) Consortium Moreno Cristiane de Araujo Martins CAM Department of Neurology, Columbia University, New York, NY 10032, USA. Kamalakaran Sitharthan S Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA. Goldstein David B DB Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA. ALS Sequencing Consortium Gitler Aaron D AD Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Harris Tim T Bioverativ, 225 2nd Avenue, Waltham, MA 02145, USA. Myers Richard M RM HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA. NYGC ALS Consortium Phatnani Hemali H Center for Genomics of Neurodegenerative Diseases (CGND), New York Genome Center, New York, NY, USA. Musunuri Rajeeva Lochan RL Computational Biology, New York Genome Center, New York, NY, USA. Evani Uday Shankar US Computational Biology, New York Genome Center, New York, NY, USA. Abhyankar Avinash A Computational Biology, New York Genome Center, New York, NY, USA. Zody Michael C MC Computational Biology, New York Genome Center, New York, NY, USA. Answer ALS Foundation Kaye Julia J Gladstone Institute of Neurological Disease, San Francisco, CA, USA. Finkbeiner Steven S Gladstone Institute of Neurological Disease, San Francisco, CA, USA; Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA, USA. Wyman Stacia K SK Gladstone Institute of Neurological Disease, San Francisco, CA, USA. LeNail Alex A Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Lima Leandro L Gladstone Institute of Neurological Disease, San Francisco, CA, USA. Fraenkel Ernest E Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Svendsen Clive N CN Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Thompson Leslie M LM Department of Neurobiology and Behavior, Institute of Memory Impairment and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA; Department of Psychiatry and Human Behavior, Institute of Memory Impairment and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA. Van Eyk Jennifer E JE The Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Berry James D JD Harvard Medical School, Department of Neurology, Massachusetts General Hospital (MGH), Boston, MA, USA; Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Miller Timothy M TM Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Kolb Stephen J SJ Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Cudkowicz Merit M Harvard Medical School, Department of Neurology, Massachusetts General Hospital (MGH), Boston, MA, USA; Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA. Baxi Emily E Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium Benatar Michael M Department of Neurology, University of Miami, Miami, FL 33136, USA. Taylor J Paul JP Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Rampersaud Evadnie E Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Wu Gang G Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Wuu Joanne J Department of Neurology, University of Miami, Miami, FL 33136, USA. SLAGEN Consortium Lauria Giuseppe G 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico "Carlo Besta," and Department of Biomedical and Clinical Sciences "Luigi Sacco," University of Milan, Milan, Italy. Verde Federico F Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy. Fogh Isabella I Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Tiloca Cinzia C Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy. Comi Giacomo P GP Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Sorarù Gianni G Department of Neurosciences, University of Padova, Padova, Italy. Cereda Cristina C Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy. French ALS Consortium Corcia Philippe P ALS Center, CHU Bretonneau, Tours University, Tours, France. Laaksovirta Hannu H Department of Neurology, Helsinki University Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki FIN-02900, Finland. Myllykangas Liisa L Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Jansson Lilja L Department of Neurology, Helsinki University Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki FIN-02900, Finland. Valori Miko M Department of Neurology, Helsinki University Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki FIN-02900, Finland. Ealing John J Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK. Hamdalla Hisham H Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK. Rollinson Sara S Faculty of Human and Medical Sciences, University of Manchester, Manchester M13 9PT, UK. Pickering-Brown Stuart S Faculty of Human and Medical Sciences, University of Manchester, Manchester M13 9PT, UK. Orrell Richard W RW Department of Clinical Neuroscience, Institute of Neurology, University College London, London NW3 2PG, UK. Sidle Katie C KC Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, Queen Square House, London WC1N 3BG, UK. Malaspina Andrea A Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, NorthEast London and Essex Regional Motor Neuron Disease Care Centre, London E1 2AT, UK. Hardy John J Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, University College London, Queen Square House, London WC1N 3BG, UK. Singleton Andrew B AB Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Johnson Janel O JO Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Arepalli Sampath S Genomics Technology Group, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Sapp Peter C PC Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. McKenna-Yasek Diane D Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Polak Meraida M Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Asress Seneshaw S Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Al-Sarraj Safa S Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. King Andrew A Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Troakes Claire C Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Vance Caroline C Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. de Belleroche Jacqueline J Division of Brain Sciences, Department of Medicine, Imperial College London, London W120NN, UK. Baas Frank F Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. Ten Asbroek Anneloor L M A ALMA Department of Neurogenetics and Neurology, Academic Medical Centre, Amsterdam, the Netherlands. Muñoz-Blanco José Luis JL ALS-Neuromuscular Unit, Hospital General Universitario Gregorio Marañón, IISGM, Madrid, Spain. Hernandez Dena G DG Genomics Technology Group, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Ding Jinhui J Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Gibbs J Raphael JR Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA. Scholz Sonja W SW Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Floeter Mary Kay MK Motor Neuron Disorders Unit, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA. Campbell Roy H RH Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Landi Francesco F Center for Geriatric Medicine, Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of Sacred Heart, Rome 00168, Italy. Bowser Robert R Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA. Pulst Stefan M SM Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. Ravits John M JM Department of Neuroscience, University of California, San Diego, La Jolla, CA, USA. MacGowan Daniel J L DJL Mount Sinai Beth Israel Hospital, Mount Sinai School of Medicine, New York, NY, USA. Kirby Janine J Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Pioro Erik P EP Department of Neurology, Neuromuscular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Pamphlett Roger R Discipline of Pathology, Brain and Mind Centre, The University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia. Broach James J Department of Biochemistry, Penn State College of Medicine, Hershey, PA, USA. Gerhard Glenn G Department of Pathology, Penn State College of Medicine, Hershey, PA, USA. Dunckley Travis L TL Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA. Brady Christopher B CB Research and Development Service, Veterans Affairs Boston Healthcare System, Boston, MA, USA; Department of Neurology, Program in Behavioral Neuroscience, Boston University School of Medicine, Boston, MA, USA. Kowall Neil W NW Neurology Service, VA Boston Healthcare System and Boston University Alzheimer's Disease Center, Boston, MA 02130, USA. Troncoso Juan C JC Departments of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Le Ber Isabelle I Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du Cerveau et la Moelle (ICM), Assistance Publique Hôpitaux de Paris (AP-HP) - Hôpital Pitié-Salpêtrière, Paris, France. Mouzat Kevin K INM, University Montpellier, Montpellier, France; Department of Biochemistry, CHU Nîmes, Nîmes, France. Lumbroso Serge S INM, University Montpellier, Montpellier, France; Department of Biochemistry, CHU Nîmes, Nîmes, France. Heiman-Patterson Terry D TD Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA; Department of Neurology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Kamel Freya F Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA. Van Den Bosch Ludo L KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Baloh Robert H RH Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Strom Tim M TM Institute of Human Genetics, Technische Universität München, Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Meitinger Thomas T Institute of Human Genetics, Technische Universität München, Munich, Germany; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Shatunov Aleksey A Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Van Eijk Kristel R KR Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. de Carvalho Mamede M Institute of Physiology, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Department of Neurosciences, Hospital de Santa Maria-CHLN, Lisbon, Portugal. Kooyman Maarten M SURFsara, Amsterdam, the Netherlands. Middelkoop Bas B Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Moisse Matthieu M KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium. McLaughlin Russell L RL Population Genetics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Republic of Ireland. Van Es Michael A MA Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Weber Markus M Neuromuscular Diseases Center/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland. Boylan Kevin B KB Department of Neurology, Mayo Clinic Florida, Jacksonville, FL 32224, USA. Van Blitterswijk Marka M Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Rademakers Rosa R Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Morrison Karen E KE Faculty of Medicine, University of Southampton, Southampton, UK. Basak A Nazli AN Suna and Inan Kırac Foundation, Neurodegeneration Research Laboratory, Bogazici University, Istanbul, Turkey. Mora Jesús S JS ALS Unit/Neurology, Hospital San Rafael, Madrid, Spain. Drory Vivian E VE Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel. Shaw Pamela J PJ Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Turner Martin R MR Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Talbot Kevin K Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Hardiman Orla O Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Republic of Ireland. Williams Kelly L KL Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Fifita Jennifer A JA Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Nicholson Garth A GA Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia. Blair Ian P IP Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Rouleau Guy A GA Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. Esteban-Pérez Jesús J Unidad de ELA, Instituto de Investigación Hospital 12 de Octubre de Madrid, SERMAS, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U-723), Madrid, Spain. García-Redondo Alberto A Unidad de ELA, Instituto de Investigación Hospital 12 de Octubre de Madrid, SERMAS, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U-723), Madrid, Spain. Al-Chalabi Ammar A Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Project MinE ALS Sequencing Consortium Rogaeva Ekaterina E Tanz Centre for Research of Neurodegenerative Diseases, Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada. Zinman Lorne L Division of Neurology, Department of Internal Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada. Ostrow Lyle W LW Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Maragakis Nicholas J NJ Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Rothstein Jeffrey D JD Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Simmons Zachary Z Department of Neurology, Penn State Hershey Medical Center, Hershey, PA, USA. Cooper-Knock Johnathan J Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Brice Alexis A Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du Cerveau et la Moelle (ICM), Assistance Publique Hôpitaux de Paris (AP-HP) - Hôpital Pitié-Salpêtrière, Paris, France. Goutman Stephen A SA Department of Neurology, University of Michigan, Ann Arbor, MI, USA. Feldman Eva L EL Department of Neurology, University of Michigan, Ann Arbor, MI, USA. Gibson Summer B SB Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA. Taroni Franco F Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan 20133, Italy. Ratti Antonia A Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center - Università degli Studi di Milano, Milan 20122, Italy. Gellera Cinzia C Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta," Milan 20133, Italy. Van Damme Philip P KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium. Robberecht Wim W KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium; VIB, Center for Brain and Disease Research, Laboratory of Neurobiology, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium. Fratta Pietro P Sobell Department of Motor Neuroscience and Movement Disorders, University College London, Institute of Neurology, London, UK. Sabatelli Mario M Centro Clinico NeMO, Institute of Neurology, Catholic University, Largo F. Vito 1, 00168 Rome, Italy. Lunetta Christian C NEuroMuscular Omnicenter (NEMO), Serena Onlus Foundation, Milan, Italy. Ludolph Albert C AC Neurology Department, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Andersen Peter M PM Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå SE-90185, Sweden. Weishaupt Jochen H JH Neurology Department, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Camu William W ALS Center, CHU Gui de Chauliac, University of Montpellier, Montpellier, France. Trojanowski John Q JQ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. Van Deerlin Vivianna M VM Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. Brown Robert H RH Jr. Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. van den Berg Leonard H LH Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Veldink Jan H JH Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. Harms Matthew B MB Department of Neurology, Columbia University, New York, NY 10032, USA. Glass Jonathan D JD Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Stone David J DJ Genetics and Pharmacogenomics, MRL, Merck & Co., Inc., West Point, PA 19486, USA. Tienari Pentti P Department of Neurology, Helsinki University Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki FIN-02900, Finland. Silani Vincenzo V Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center - Università degli Studi di Milano, Milan 20122, Italy. Chiò Adriano A "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Turin, Italy; Neuroscience Institute of Torino, Turin 10124, Italy. Shaw Christopher E CE Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London SE5 9RS, UK. Traynor Bryan J BJ Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD 20892, USA; Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address: bryan.traynor@nih.gov. Landers John E JE Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: john.landers@umassmed.edu. eng ZIA AG000933-03 Intramural NIH HHS United States Journal Article

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M Zollino Marcella M Conte Amelia A Luigetti Marco M Lattante Serena S Marangi Giuseppe G Santarelli Marialuisa M Petrucci Antonio A Pugliatti Maura M Pirisi Angelo A Parish Leslie D LD Occhineri Patrizia P Giannini Fabio F Battistini Stefania S Ricci Claudia C Benigni Michele M Cau Tea B TB Loi Daniela D Calvo Andrea A Moglia Cristina C Brunetti Maura M Barberis Marco M Restagno Gabriella G Casale Federico F Marrali Giuseppe G Fuda Giuseppe G Ossola Irene I Cammarosano Stefania S Canosa Antonio A Ilardi Antonio A Manera Umberto U Grassano Maurizio M Tanel Raffaella R Pisano Fabrizio F Harms Matthew B MB Goldstein David B DB Shneider Neil A NA Goutman Stephen S Simmons Zachary Z Miller Timothy M TM Chandran Siddharthan S Pal Suvankar S Manousakis George G Appel Stanley H SH Simpson Ericka E Wang Leo L Baloh Robert H RH Gibson Summer S Bedlack Richard R Lacomis David D Sareen Dhruv D Sherman Alexander A Bruijn Lucie L Penny Michelle M Allen Andrew S AS Appel Stanley S Baloh Robert H RH Bedlack Richard S RS Boone Braden E BE Brown Robert R Carulli John P JP Chesi Alessandra A Chung Wendy K WK Cirulli Elizabeth T ET Cooper Gregory M GM Couthouis Julien J Day-Williams Aaron G AG Dion Patrick A PA Gibson Summer S Gitler Aaron D AD Glass Jonathan D JD Goldstein David B DB Han Yujun Y Harms Matthew B MB Harris Tim T Hayes Sebastian D SD Jones Angela L AL Keebler Jonathan J Krueger Brian J BJ Lasseigne Brittany N BN Levy Shawn E SE Lu Yi-Fan YF Maniatis Tom T McKenna-Yasek Diane D Miller Timothy M TM Myers Richard M RM Petrovski Slavé S Pulst Stefan M SM Raphael Alya R AR Ravits John M JM Ren Zhong Z Rouleau Guy A GA Sapp Peter C PC Shneider Neil A NA Simpson Ericka E Sims Katherine B KB Staropoli John F JF Waite Lindsay L LL Wang Quanli Q Wimbish Jack R JR Xin Winnie W WW Phatnani Hemali H Kwan Justin J Sareen Dhruv D Broach James R JR Simmons Zachary Z Arcila-Londono Ximena X Lee Edward B EB Van Deerlin Vivianna M VM Shneider Neil A NA Fraenkel Ernest E Ostrow Lyle W LW Baas Frank F Zaitlen Noah N Berry James D JD Malaspina Andrea A Fratta Pietro P Cox Gregory A GA Thompson Leslie M LM Finkbeiner Steve S Dardiotis Efthimios E Miller Timothy M TM Chandran Siddharthan S Pal Suvankar S Hornstein Eran E MacGowan Daniel J DJ Heiman-Patterson Terry T Hammell Molly G MG Patsopoulos Nikolaos A NA Dubnau Joshua J Nath Avindra A Kaye Julia J Finkbeiner Steven S Wyman Stacia S LeNail Alexander A Lima Leandro L Fraenkel Ernest E Rothstein Jeffrey D JD Svendsen Clive N CN Thompson Leslie M LM Van Eyk Jenny J Maragakis Nicholas J NJ Berry James D JD Glass Jonathan D JD Miller Timothy M TM Kolb Stephen J SJ Baloh Robert H RH Cudkowicz Merit M Baxi Emily E Benatar Michael M Taylor J Paul JP Wu Gang G Rampersaud Evadnie E Wuu Joanne J Rademakers Rosa R Züchner Stephan S Schule Rebecca R McCauley Jacob J Hussain Sumaira S Cooley Anne A Wallace Marielle M Clayman Christine C Barohn Richard R Statland Jeffrey J Ravits John J Swenson Andrea A Jackson Carlayne C Trivedi Jaya J Khan Shaida S Katz Jonathan J Jenkins Liberty L Burns Ted T Gwathmey Kelly K Caress James J McMillan Corey C Elman Lauren L Pioro Erik E Heckmann Jeannine J So Yuen Y Walk David D Maiser Samuel S Zhang Jinghui J Silani Vincenzo V Ticozzi Nicola N Gellera Cinzia C Ratti Antonia A Taroni Franco F Lauria Giuseppe G Verde Federico F Fogh Isabella I Tiloca Cinzia C Comi Giacomo P GP Sorarù Gianni G Cereda Cristina C D'Alfonso Sandra S Corrado Lucia L De Marchi Fabiola F Corti Stefania S Ceroni Mauro M Mazzini Letizia L Siciliano Gabriele G Filosto Massimiliano M Inghilleri Maurizio M Peverelli Silvia S Colombrita Claudia C Poletti Barbara B Maderna Luca L Del Bo Roberto R Gagliardi Stella S Querin Giorgia G Bertolin Cinzia C Pensato Viviana V Castellotti Barbara B Camu William W Mouzat Kevin K Lumbroso Serge S Corcia Philippe P Meininger Vincent V Besson Gérard G Lagrange Emmeline E Clavelou Pierre P Guy Nathalie N Couratier Philippe P Vourch Patrick P Danel Véronique V Bernard Emilien E Lemasson Gwendal G Al Kheifat Ahmad A Al-Chalabi Ammar A Andersen Peter P Basak A Nazli AN Blair Ian P IP Chio Adriano A Cooper-Knock Jonathan J Corcia Philippe P Couratier Philippe P de Carvalho Mamede M Dekker Annelot A Drory Vivian V Redondo Alberto Garcia AG Gotkine Marc M Hardiman Orla O Hide Winston W Iacoangeli Alfredo A Glass Jonathan J Kenna Kevin K Kiernan Matthew M Kooyman Maarten M Landers John J McLaughlin Russell R Middelkoop Bas B Mill Jonathan J Neto Miguel Mitne MM Moisse Mattieu M Pardina Jesus Mora JM Morrison Karen K Newhouse Stephen S Pinto Susana S Pulit Sara S Robberecht Wim W Shatunov Aleksey A Shaw Pamela P Shaw Chris C Silani Vincenzo V Sproviero William W Tazelaar Gijs G Ticozzi Nicola N van Damme Philip P van den Berg Leonard L van der Spek Rick R van Eijk Kristel K van Es Michael M van Rheenen Wouter W van Vugt Joke J Veldink Jan J Weber Markus M Williams Kelly L KL Zatz Mayana M Bauer Denis C DC Twine Natalie A NA 2017 12 21 2018 01 21 2018 02 26 2019 03 21 2018 3 24 6 0 2018 3 24 6 0 2018 3 24 6 0 ppublish 29566793 S0896-6273(18)30148-X 10.1016/j.neuron.2018.02.027 PMC5867896 NIHMS950505 29559933 2018 03 30

1664-1078 9 2018 Front Psychol Impact of Oncoming Headlight Glare With Cataracts: A Pilot Study. 164 10.3389/fpsyg.2018.00164 Purpose: Oncoming headlight glare (HLG) reduces the visibility of objects on the road and may affect the safety of nighttime driving. With cataracts, the impact of oncoming HLG is expected to be more severe. We used our custom HLG simulator in a driving simulator to measure the impact of HLG on pedestrian detection by normal vision subjects with simulated mild cataracts and by patients with real cataracts.Methods:Five normal vision subjects drove nighttime scenarios under two HLG conditions (with and without HLG: HLGY and HLGN, respectively), and three vision conditions (with plano lens, simulated mild cataract, and optically blurred clip-on). Mild cataract was simulated by applying a 0.8 Bangerter diffusion foil to clip-on plano lenses. The visual acuity with the optically blurred lenses was individually chosen to match the visual acuity with the simulated cataract clip-ons under HLGN. Each nighttime driving scenario contains 24 pedestrian encounters, encompassing four pedestrian types; walking along the left side of the road, walking along the right side of the road, crossing the road from left to right, and crossing the road from right to left. Pedestrian detection performances of five patients with mild real cataracts were measured using the same setup. The cataract patients were tested only in HLGY and HLGN conditions. Participants' visual acuity and contrast sensitivity were also measured in the simulator with and without stationary HLG.Results:For normal vision subjects, both the presence of oncoming HLG and wearing the simulated cataract clip-on reduced pedestrian detection performance. The subjects performed worst in events where the pedestrian crossed from the left, followed by events where the pedestrian crossed from the right. Significant interactions between HLG condition and other factors were also found: (1) the impact of oncoming HLG with the simulated cataract clip-on was larger than with the plano lens clip-on, (2) the impact of oncoming HLG was larger with the optically blurred clip-on than with the plano lens clip-on, but smaller than with the simulated cataract clip-on, and (3) the impact was larger for the pedestrians that crossed from the left than those that crossed from the right, and for the pedestrians walking along the left side of the road than walking along the right side of the road, suggesting that the pedestrian proximity to the glare source contributed to the performance reduction. Under HLGN, almost no pedestrians were missed with the plano lens or the simulated cataract clip-on (0 and 0.5%, respectively), but under HLGY, the rate of pedestrian misses increased to 0.5 and 6%, respectively. With the optically blurred clip-on, the percent of missed pedestrians under HLGN and HLGY did not change much (5% and 6%, respectively). Untimely response rate increased under HLGY with the plano lens and simulated cataract clip-ons, but the increase with the simulated cataract clip-on was significantly larger than with the plano lens clip-on. The contrast sensitivity with the simulated cataract clip-on was significantly degraded under HLGY. The visual acuity with the plano lens clip-on was significantly improved under HLGY, possibly due to pupil myosis. The impact of HLG measured for real cataract patients was similar to the impact on performance of normal vision subjects with simulated cataract clip-ons.Conclusion:Even with mild (simulated or real) cataracts, a substantial negative effect of oncoming HLG was measurable in the detection of crossing and walking-along pedestrians. The lowered pedestrian detection rates and longer response times with HLGY demonstrate a possible risk that oncoming HLG poses to patients driving with cataracts. Hwang Alex D AD Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, United States. Tuccar-Burak Merve M Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, United States. Goldstein Robert R Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, United States. Peli Eli E Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, United States. eng P30 EY003790 EY NEI NIH HHS United States Journal Article 2018 03 06

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1536-481X 2018 Mar 19 J. Glaucoma The Influence of Corneal Biomechanical Properties on Intraocular Pressure Measurements Using a Rebound Self-tonometer. 10.1097/IJG.0000000000000948 To examine the effect of corneal biomechanical properties on intraocular pressure (IOP) measurements obtained using a rebound self-tonometer (Icare HOME) compared to Goldmann applanation tonometry (GAT). An observational study of 100 patients with glaucoma or ocular hypertension. All had a comprehensive ophthalmic examination and standard automated perimetry. IOP was assessed by GAT, Icare HOME and Ocular Response Analyzer (ORA), which was also used to assess corneal hysteresis (CH) and corneal resistance factor (CRF). Central corneal thickness (CCT) was recorded. Mean (±standard deviation) IOP measurements were 14.3±3.9▒mmHg and 11.7±4.7▒mmHg using GAT and Icare HOME respectively. Average CCT, CRF and CH were 534.5±37.3▒μm, 9.0±1.7▒mmHg, and 9.4±1.5▒mmHg respectively. The mean difference between Icare HOME and GAT was -2.66±3.13▒mmHg, with 95% limits of agreement of -8.80 to 3.48▒mmHg, however, there was evidence of proportional bias. There was negative correlation between IOP and CH (5.17▒mmHg higher Icare HOME IOP (P=0.041, R=0.029) and 7.23▒mmHg higher GAT IOP (P=0.008, R=0.080) for each 10▒mmHg lower CH), while thinner CCT was significantly associated with lower IOP (P<0.001, R=0.14 for Icare HOME and P<0.001, R=0.08 for GAT). In multivariable analysis, although CRF and CH remained associated with IOP measured using either GAT or ICare HOME, CCT was no longer significant. IOP measurements obtained using a self-tonometer, similar to GAT, were more influenced by overall corneal biomechanics than central corneal thickness. Brown Lyndsay L Princess Alexandra Eye Pavilion, Department of Ophthalmology, University of Edinburgh, Edinburgh, EH3 9HA, UK. Foulsham William W Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Pronin Savva S Princess Alexandra Eye Pavilion, Department of Ophthalmology, University of Edinburgh, Edinburgh, EH3 9HA, UK. Tatham Andrew J AJ Princess Alexandra Eye Pavilion, Department of Ophthalmology, University of Edinburgh, Edinburgh, EH3 9HA, UK. eng Journal Article 2018 03 19

United States J Glaucoma 9300903 1057-0829 2018 3 21 6 0 2018 3 21 6 0 2018 3 21 6 0 aheadofprint 29557828 10.1097/IJG.0000000000000948 29557698 2018 03 20

1744-5108 2018 Mar 20 Orbit Myeloid sarcoma involving the greater wing of the sphenoid bone and additional skeletal sites presenting with unilateral proptosis and fevers. 1-4 10.1080/01676830.2018.1449225 We report a case of myeloid sarcoma with multifocal skeletal involvement, including the greater wing of the sphenoid bone. A 23-month-old boy presented with left-sided proptosis and fevers, and was found to have an infiltrative mass involving the left sphenoid bone on orbital imaging. Full body imaging further demonstrated multiple bony lesions in the pelvis, thoracic and lumbar vertebrae, bilateral femura, and left humerus, and biopsies of the humerus were consistent with myeloid sarcoma. The patient was started on a standard chemotherapy regimen and is responding well. Myeloid sarcoma presenting with proptosis due to sphenoid bone involvement with simultaneous multifocal skeletal involvement is very uncommon and highlights the importance of biopsy for establishing a definitive diagnosis. Wang Jay C JC a Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology , Harvard Medical School , Boston , MA , USA. Jiménez Pérez Juan C JC a Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology , Harvard Medical School , Boston , MA , USA. Friedmann Alison M AM b Department of Pediatrics , Massachusetts General Hospital Cancer Center , Boston , MA , USA. Louissaint Abner A c Department of Pathology , Massachusetts General Hospital , Boston , MA , USA. Freitag Suzanne K SK a Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology , Harvard Medical School , Boston , MA , USA. eng Journal Article 2018 03 20

England Orbit 8301221 0167-6830 Myeloid sarcoma proptosis sphenoid bone 2018 3 21 6 0 2018 3 21 6 0 2018 3 21 6 0 aheadofprint 29557698 10.1080/01676830.2018.1449225 29555514 2018 03 20

1528-3933 2018 Mar 16 J AAPOS Congenital muscular dystrophy-dystroglycanopathy, type A featuring bilateral retinal dysplasia and vertical angle kappa. S1091-8531(17)30444-5 10.1016/j.jaapos.2017.12.011 Peiris Timothy J TJ Rutgers New Jersey Medical School, Newark, New Jersey. Indaram Maanasa M Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Koo Euna E Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Soul Janet S JS Department of Neurology, Boston Children's Hospital, Boston, Massachusetts; Department of Neurology, Harvard Medical School, Boston, Massachusetts. Hunter David G DG Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address: david.hunter@childrens.harvard.edu. eng Journal Article 2018 03 16

United States J AAPOS 9710011 1091-8531 2017 06 01 2017 12 17 2017 12 19 2018 3 21 6 0 2018 3 21 6 0 2018 3 21 6 0 aheadofprint 29555514 S1091-8531(17)30444-5 10.1016/j.jaapos.2017.12.011 29549330 2018 03 17

1546-1718 2018 Mar 16 Nat. Genet. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0082-3 In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of the article. Turcot Valérie V Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Lu Yingchang Y Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Highland Heather M HM Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Schurmann Claudia C http://orcid.org/0000-0003-4158-9192 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Justice Anne E AE http://orcid.org/0000-0002-8903-8712 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Fine Rebecca S RS Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Genetics, Harvard Medical School, Boston, MA, USA. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA. Bradfield Jonathan P JP Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Quantinuum Research, LLC, San Diego, CA, USA. Esko Tõnu T Broad Institute of MIT and Harvard, Cambridge, MA, USA. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA. Estonian Genome Center, University of Tartu, Tartu, Estonia. Giri Ayush A http://orcid.org/0000-0002-7786-4670 Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Graff Mariaelisa M Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Guo Xiuqing X Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Hendricks Audrey E AE Wellcome Trust Sanger Institute, Hinxton, UK. Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA. Karaderi Tugce T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus. Lempradl Adelheid A Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Locke Adam E AE http://orcid.org/0000-0001-6227-198X Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. Mahajan Anubha A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Marouli Eirini E William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Sivapalaratnam Suthesh S Department of Vascular Medicine, AMC, Amsterdam, The Netherlands. Massachusetts General Hospital, Boston, MA, USA. Department of Haematology, University of Cambridge, Cambridge, UK. Young Kristin L KL http://orcid.org/0000-0003-0070-6145 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Alfred Tamuno T Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Masca Nicholas G D NGD Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Manning Alisa K AK Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Department of Medicine, Harvard Medical School, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Medina-Gomez Carolina C http://orcid.org/0000-0001-7999-5538 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Mudgal Poorva P Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Ng Maggie C Y MCY Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Reiner Alex P AP Department of Epidemiology, University of Washington, Seattle, WA, USA. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Vedantam Sailaja S Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Genetics, Harvard Medical School, Boston, MA, USA. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA. Willems Sara M SM MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Winkler Thomas W TW http://orcid.org/0000-0003-0292-5421 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Abecasis Gonçalo G Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Aben Katja K KK Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands. Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Alam Dewan S DS School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada. Alharthi Sameer E SE William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia. Allison Matthew M Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA. Amouyel Philippe P INSERM U1167, Lille, France. Institut Pasteur de Lille, U1167, Lille, France. Université de Lille, U1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. Asselbergs Folkert W FW Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK. Auer Paul L PL Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. Balkau Beverley B INSERM U1018, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France. Bang Lia E LE Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Barroso Inês I Wellcome Trust Sanger Institute, Hinxton, UK. Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Bastarache Lisa L Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Benn Marianne M Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Bergmann Sven S Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Blüher Matthias M IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, Germany. Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Boeing Heiner H Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. Boerwinkle Eric E School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. Böger Carsten A CA Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Bork-Jensen Jette J Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Bots Michiel L ML Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Bottinger Erwin P EP Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Bowden Donald W DW Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. Brandslund Ivan I Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark. Breen Gerome G MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK. Brilliant Murray H MH Marshfield Clinic Research Institute, Marshfield, WI, USA. Broer Linda L Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Brumat Marco M Department of Medical Sciences, University of Trieste, Trieste, Italy. Burt Amber A AA Department of Medicine, University of Washington, Seattle, WA, USA. Butterworth Adam S AS MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Campbell Peter T PT Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. Cappellani Stefania S Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Carey David J DJ Weis Center for Research, Geisinger Health System, Danville, PA, USA. Catamo Eulalia E Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Caulfield Mark J MJ William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Chambers John C JC Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Imperial College Healthcare NHS Trust, London, UK. Chasman Daniel I DI Broad Institute of MIT and Harvard, Cambridge, MA, USA. Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Chen Yii-Der I YI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Chowdhury Rajiv R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Christensen Cramer C Medical Department, Lillebaelt Hospital, Vejle, Denmark. Chu Audrey Y AY NHLBI Framingham Heart Study, Framingham, MA, USA. Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA. Cocca Massimiliano M Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. Collins Francis S FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. Cook James P JP Department of Biostatistics, University of Liverpool, Liverpool, UK. Corley Janie J Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Department of Psychology, University of Edinburgh, Edinburgh, UK. Corominas Galbany Jordi J Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Cox Amanda J AJ Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA. Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia. Crosslin David S DS Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA. Cuellar-Partida Gabriel G Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. D'Eustacchio Angela A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Danesh John J Wellcome Trust Sanger Institute, Hinxton, UK. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK. Davies Gail G Department of Biostatistics, University of Liverpool, Liverpool, UK. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Bakker Paul I W PIW Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. Groot Mark C H MCH Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands. Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands. Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Deary Ian J IJ Department of Biostatistics, University of Liverpool, Liverpool, UK. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. Heijer Martin M Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. Hollander Anneke I AI Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Ruijter Hester M HM Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Dennis Joe G JG Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Denny Josh C JC Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Di Angelantonio Emanuele E MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Drenos Fotios F Institute of Cardiovascular Science, University College London, London, UK. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK. Du Mengmeng M Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Dubé Marie-Pierre MP Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Edwards Todd L TL Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Ellinghaus David D Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. Ellinor Patrick T PT Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Elliott Paul P Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. Evangelou Evangelos E Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. Farmaki Aliki-Eleni AE Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. Department of Health Sciences, University of Leicester, Leicester, UK. Farooqi I Sadaf IS Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. Fauser Sascha S Department of Ophthalmology, University of Cologne, Cologne, Germany. Feng Shuang S Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Ferrannini Ele E CNR Institute of Clinical Physiology, Pisa, Italy. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Ferrieres Jean J Toulouse University School of Medicine, Toulouse, France. Florez Jose C JC Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Department of Medicine, Harvard Medical School, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Ford Ian I University of Glasgow, Glasgow, UK. Fornage Myriam M Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Franco Oscar H OH Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Franke Andre A Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. Franks Paul W PW Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. Friedrich Nele N Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Frikke-Schmidt Ruth R Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Galesloot Tessel E TE Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Gan Wei W Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Gandin Ilaria I Research Unit, AREA Science Park, Trieste, Italy. Gasparini Paolo P Department of Medical Sciences, University of Trieste, Trieste, Italy. Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Gibson Jane J Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK. Giedraitis Vilmantas V Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden. Gjesing Anette P AP Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Gordon-Larsen Penny P Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. Gorski Mathias M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Grabe Hans-Jörgen HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany. Grant Struan F A SFA Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Division of Endocrinology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Griffiths Helen L HL Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK. Grove Megan L ML School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Icelandic Heart Association, Kopavogur, Iceland. Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Haessler Jeff J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Hakonarson Hakon H Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Hammerschlag Anke R AR Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands. Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Harris Kathleen Mullan KM Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. Department of Sociology, University of North Carolina, Chapel Hill, NC, USA. Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. Hattersley Andrew T AT University of Exeter Medical School, University of Exeter, Exeter, UK. Have Christian T CT Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. He Liang L Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. Department of Public Health, University of Helsinki, Helsinki, Finland. Heard-Costa Nancy L NL NHLBI Framingham Heart Study, Framingham, MA, USA. Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Heath Andrew C AC Department of Psychiatry, Washington University, St. Louis, MO, USA. Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Helgeland Øyvind Ø Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Hernesniemi Jussi J Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Hewitt Alex W AW Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia. Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia. Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Holmen Oddgeir L OL KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. Hovingh G Kees GK Department of Vascular Medicine, AMC, Amsterdam, The Netherlands. Howson Joanna M M JMM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Hu Yao Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Huang Paul L PL Massachusetts General Hospital, Boston, MA, USA. Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Ikram M Arfan MA Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands. Ingelsson Erik E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Jansson Jan-Håkan JH Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Research Unit Skellefteå, Skellefteå, Sweden. Jarvik Gail P GP Department of Medicine, University of Washington, Seattle, WA, USA. Department of Genome Sciences, University of Washington, Seattle, WA, USA. Jensen Gorm B GB Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark. Jia Yucheng Y Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Johansson Stefan S KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Jørgensen Marit E ME National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. Steno Diabetes Center Copenhagen, Gentofte, Denmark. Jørgensen Torben T Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Faculty of Medicine, Aalborg University, Aalborg, Denmark. Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Jukema J Wouter JW Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands. Kahali Bratati B Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. Centre for Brain Research, Indian Institute of Science, Bangalore, India. Kahn René S RS Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Kähönen Mika M Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. Kamstrup Pia R PR Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Karaleftheri Maria M Echinos Medical Centre, Echinos, Greece. Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Karpe Fredrik F Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Kathiresan Sekar S Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Kee Frank F UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK. Kiemeney Lambertus A LA Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Kim Eric E Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Kitajima Hidetoshi H Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Komulainen Pirjo P Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Kooner Jaspal S JS Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK. Imperial College Healthcare NHS Trust, London, UK. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, UK. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. Kooperberg Charles C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Korhonen Tellervo T Department of Public Health, University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Kovacs Peter P IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. Kuivaniemi Helena H Weis Center for Research, Geisinger Health System, Danville, PA, USA. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Kutalik Zoltán Z Swiss Institute of Bioinformatics, Lausanne, Switzerland. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. Kuulasmaa Kari K National Institute for Health and Welfare, Helsinki, Finland. Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Lakka Timo A TA Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Lamparter David D Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Lange Ethan M EM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Lange Leslie A LA Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Larson Eric B EB Department of Medicine, University of Washington, Seattle, WA, USA. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. Department of Health Services, University of Washington, Seattle, WA, USA. Lee Nanette R NR Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines. USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines. Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Lewis Cora E CE Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Li Huaixing H Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Li Jin J Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Lin Honghuang H Department of Medicine, Boston University School of Medicine, Boston, MA, USA. Lin Keng-Hung KH Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan. Lin Li-An LA Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Lin Xu X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Lind Lars L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Lindström Jaana J National Institute for Health and Welfare, Helsinki, Finland. Linneberg Allan A Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Liu Dajiang J DJ Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA. Liu Yongmei Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Lo Ken S KS Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Lophatananon Artitaya A Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK. Lotery Andrew J AJ Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK. Loukola Anu A Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Lubitz Steven A SA Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Männistö Satu S National Institute for Health and Welfare, Helsinki, Finland. Marenne Gaëlle G Wellcome Trust Sanger Institute, Hinxton, UK. Mazul Angela L AL Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. McCarthy Mark I MI Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. McKean-Cowdin Roberta R Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Meidtner Karina K Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. German Center for Diabetes Research, Neuherberg, Germany. Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia. Mistry Vanisha V Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Mitchell Paul P Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia. Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Moilanen Leena L Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Moitry Marie M Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France. Department of Public Health, University Hospital of Strasbourg, Strasbourg, France. Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. Mook-Kanamori Dennis O DO Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. Moore Carmel C NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Mori Trevor A TA School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. Morris Andrew D AD Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. Morris Andrew P AP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Department of Biostatistics, University of Liverpool, Liverpool, UK. Müller-Nurasyid Martina M Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Department of Medicine I, University Hospital Großhadern, Ludwig-Maximilians-Universitat, Munich, Germany. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. Munroe Patricia B PB William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Nalls Mike A MA Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA. Data Tecnica International, Glen Echo, MD, USA. Narisu Narisu N Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. Nelson Christopher P CP Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Neville Matt M Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Nielsen Sune F SF Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Nikus Kjell K Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Njølstad Pål R PR Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Nordestgaard Børge G BG Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Nyholt Dale R DR QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. O'Connel Jeffrey R JR Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. O'Donoghue Michelle L ML Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Ophoff Roel A RA Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Owen Katharine R KR Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Packard Chris J CJ University of Glasgow, Glasgow, UK. Padmanabhan Sandosh S University of Glasgow, Glasgow, UK. Palmer Colin N A CNA Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK. Palmer Nicholette D ND Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. Pasterkamp Gerard G Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands. Patel Aniruddh P AP Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Pattie Alison A Department of Psychology, University of Edinburgh, Edinburgh, UK. Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Peissig Peggy L PL Marshfield Clinic Research Institute, Marshfield, WI, USA. Peloso Gina M GM Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Pennell Craig E CE School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia. Perola Markus M Estonian Genome Center, University of Tartu, Tartu, Estonia. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland. Perry James A JA Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Pers Tune H TH Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. Person Thomas N TN Marshfield Clinic Research Institute, Marshfield, WI, USA. Peters Annette A German Center for Diabetes Research, Neuherberg, Germany. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Petersen Eva R B ERB Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark. Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Polasek Ozren O Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. School of Medicine, University of Split, Split, Croatia. Polderman Tinca J TJ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands. Puolijoki Hannu H Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland. Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Rasheed Asif A Centre for Non-Communicable Diseases, Karachi, Pakistan. Rauramaa Rainer R Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Reilly Dermot F DF Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA. Renström Frida F Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden. Department of Biobank Research, Umeå University, Umeå, Sweden. Rheinberger Myriam M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Ridker Paul M PM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Rioux John D JD Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Rivas Manuel A MA Broad Institute of MIT and Harvard, Cambridge, MA, USA. Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Roberts David J DJ NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NHS Blood and Transplant-Oxford Centre, Oxford, UK. BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Robertson Neil R NR Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Robino Antonietta A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Rolandsson Olov O Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden. Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. Saleheen Danish D Centre for Non-Communicable Diseases, Karachi, Pakistan. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Salomaa Veikko V National Institute for Health and Welfare, Helsinki, Finland. Samani Nilesh J NJ Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Sapkota Yadav Y QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Sattar Naveed N University of Glasgow, Glasgow, UK. Schoen Robert E RE Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Schreiner Pamela J PJ Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. Schulze Matthias B MB Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. German Center for Diabetes Research, Neuherberg, Germany. Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Segura-Lepe Marcelo P MP Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Shah Svati H SH Duke Molecular Physiology Institute, Duke University, Durham, NC, USA. Sheu Wayne H-H WH Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. School of Medicine, National Defense Medical Center, Taipei, Taiwan. School of Medicine, National Yang-Ming University, Taipei, Taiwan. Sim Xueling X Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore. 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United States Nat Genet 9216904 1061-4036 Nat Genet. 2018 Jan;50(1):26-41 29273807 2018 3 18 6 0 2018 3 20 6 0 2018 3 20 6 0 aheadofprint 29549330 10.1038/s41588-018-0082-3 10.1038/s41588-018-0082-3 29549329 2018 03 17

1546-1718 2018 Mar 16 Nat. Genet. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 10.1038/s41588-018-0050-y In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article. Turcot Valérie V Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Lu Yingchang Y Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Highland Heather M HM Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. Schurmann Claudia C http://orcid.org/0000-0003-4158-9192 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Justice Anne E AE http://orcid.org/0000-0002-8903-8712 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. Fine Rebecca S RS Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Genetics, Harvard Medical School, Boston, MA, USA. 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Davies Gail G Department of Biostatistics, University of Liverpool, Liverpool, UK. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Bakker Paul I W PIW Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. Groot Mark C H MCH Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands. Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands. Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Deary Ian J IJ Department of Biostatistics, University of Liverpool, Liverpool, UK. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. Heijer Martin M Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands. Hollander Anneke I AI Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Ruijter Hester M HM Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Dennis Joe G JG Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Denny Josh C JC Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. Angelantonio Emanuele E MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Drenos Fotios F Institute of Cardiovascular Science, University College London, London, UK. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK. Du Mengmeng M Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Dubé Marie-Pierre MP Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Edwards Todd L TL Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Ellinghaus David D Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. Ellinor Patrick T PT Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Elliott Paul P Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. Evangelou Evangelos E Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. Farmaki Aliki-Eleni AE Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. Department of Health Sciences, University of Leicester, Leicester, UK. Farooqi I Sadaf IS Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. Fauser Sascha S Department of Ophthalmology, University of Cologne, Cologne, Germany. Feng Shuang S Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Ferrannini Ele E CNR Institute of Clinical Physiology, Pisa, Italy. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Ferrieres Jean J Toulouse University School of Medicine, Toulouse, France. Florez Jose C JC Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Department of Medicine, Harvard Medical School, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Ford Ian I University of Glasgow, Glasgow, UK. Fornage Myriam M Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Franco Oscar H OH Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Franke Andre A Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. Franks Paul W PW Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden. Friedrich Nele N Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Frikke-Schmidt Ruth R Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Galesloot Tessel E TE Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Gan Wei W Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Gandin Ilaria I Research Unit, AREA Science Park, Trieste, Italy. Gasparini Paolo P Department of Medical Sciences, University of Trieste, Trieste, Italy. Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Gibson Jane J Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK. Giedraitis Vilmantas V Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden. Gjesing Anette P AP Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Gordon-Larsen Penny P Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. Gorski Mathias M Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Grabe Hans-Jörgen HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany. Grant Struan F A SFA Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Division of Endocrinology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Griffiths Helen L HL Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK. Grove Megan L ML School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Icelandic Heart Association, Kopavogur, Iceland. Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Haessler Jeff J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Hakonarson Hakon H Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Hammerschlag Anke R AR Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands. Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Harris Kathleen Mullan KM Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. Department of Sociology, University of North Carolina, Chapel Hill, NC, USA. Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. Hattersley Andrew T AT University of Exeter Medical School, University of Exeter, Exeter, UK. Have Christian T CT Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. He Liang L Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. Department of Public Health, University of Helsinki, Helsinki, Finland. Heard-Costa Nancy L NL NHLBI Framingham Heart Study, Framingham, MA, USA. Department of Neurology, Boston University School of Medicine, Boston, MA, USA. Heath Andrew C AC Department of Psychiatry, Washington University, St. Louis, MO, USA. Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Helgeland Øyvind Ø Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Hernesniemi Jussi J Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Hewitt Alex W AW Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia. Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia. Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia. Holmen Oddgeir L OL KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. Hovingh G Kees GK Department of Vascular Medicine, AMC, Amsterdam, The Netherlands. Howson Joanna M M JMM MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Hu Yao Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Huang Paul L PL Massachusetts General Hospital, Boston, MA, USA. Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Ikram M Arfan MA Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands. Ingelsson Erik E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Jansson Jan-Håkan JH Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Research Unit Skellefteå, Skellefteå, Sweden. Jarvik Gail P GP Department of Medicine, University of Washington, Seattle, WA, USA. Department of Genome Sciences, University of Washington, Seattle, WA, USA. Jensen Gorm B GB Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark. Jia Yucheng Y Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Johansson Stefan S KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Jørgensen Marit E ME National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. Steno Diabetes Center Copenhagen, Gentofte, Denmark. Jørgensen Torben T Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Faculty of Medicine, Aalborg University, Aalborg, Denmark. Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Jukema J Wouter JW Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands. Kahali Bratati B Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. Centre for Brain Research, Indian Institute of Science, Bangalore, India. Kahn René S RS Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Kähönen Mika M Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. Kamstrup Pia R PR Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Kanoni Stavroula S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Kaprio Jaakko J Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Karaleftheri Maria M Echinos Medical Centre, Echinos, Greece. Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Karpe Fredrik F Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Kathiresan Sekar S Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Kee Frank F UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK. Kiemeney Lambertus A LA Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Kim Eric E Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Kitajima Hidetoshi H Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Komulainen Pirjo P Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Kooner Jaspal S JS Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK. Imperial College Healthcare NHS Trust, London, UK. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, UK. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. Kooperberg Charles C Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Korhonen Tellervo T Department of Public Health, University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Kovacs Peter P IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. Kuivaniemi Helena H Weis Center for Research, Geisinger Health System, Danville, PA, USA. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Kutalik Zoltán Z Swiss Institute of Bioinformatics, Lausanne, Switzerland. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. Kuulasmaa Kari K National Institute for Health and Welfare, Helsinki, Finland. Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Lakka Timo A TA Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Lamparter David D Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Lange Ethan M EM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Lange Leslie A LA Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Larson Eric B EB Department of Medicine, University of Washington, Seattle, WA, USA. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. Department of Health Services, University of Washington, Seattle, WA, USA. Lee Nanette R NR Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines. USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines. Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Lewis Cora E CE Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Li Huaixing H Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Li Jin J Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Li-Gao Ruifang R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Lin Honghuang H Department of Medicine, Boston University School of Medicine, Boston, MA, USA. Lin Keng-Hung KH Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan. Lin Li-An LA Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Lin Xu X Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Lind Lars L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden. Lindström Jaana J National Institute for Health and Welfare, Helsinki, Finland. Linneberg Allan A Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Liu Dajiang J DJ Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA. Liu Yongmei Y Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Lo Ken S KS Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Lophatananon Artitaya A Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK. Lotery Andrew J AJ Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK. Loukola Anu A Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Lubitz Steven A SA Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA. Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Männistö Satu S National Institute for Health and Welfare, Helsinki, Finland. Marenne Gaëlle G Wellcome Trust Sanger Institute, Hinxton, UK. Mazul Angela L AL Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. McCarthy Mark I MI Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. McKean-Cowdin Roberta R Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Meidtner Karina K Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. German Center for Diabetes Research, Neuherberg, Germany. Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia. Mistry Vanisha V Metabolic Research Laboratories, University of Cambridge, Cambridge, UK. NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Mitchell Paul P Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia. Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Moilanen Leena L Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Moitry Marie M Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France. Department of Public Health, University Hospital of Strasbourg, Strasbourg, France. Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. Mook-Kanamori Dennis O DO Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. Moore Carmel C NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Mori Trevor A TA School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. Morris Andrew D AD Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. Morris Andrew P AP Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Department of Biostatistics, University of Liverpool, Liverpool, UK. Müller-Nurasyid Martina M Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Department of Medicine I, University Hospital Großhadern, Ludwig-Maximilians-Universitat, Munich, Germany. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. Munroe Patricia B PB William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Nalls Mike A MA Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA. Data Tecnica International, Glen Echo, MD, USA. Narisu Narisu N Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. Nelson Christopher P CP Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Neville Matt M Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Nielsen Sune F SF Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Nikus Kjell K Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Njølstad Pål R PR Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Nordestgaard Børge G BG Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Nyholt Dale R DR QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. O'Connel Jeffrey R JR Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. O'Donoghue Michelle L ML Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Ophoff Roel A RA Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Owen Katharine R KR Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK. Packard Chris J CJ University of Glasgow, Glasgow, UK. Padmanabhan Sandosh S University of Glasgow, Glasgow, UK. Palmer Colin N A CNA Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK. Palmer Nicholette D ND Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. Pasterkamp Gerard G Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands. Patel Aniruddh P AP Broad Institute of MIT and Harvard, Cambridge, MA, USA. Massachusetts General Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Pattie Alison A Department of Psychology, University of Edinburgh, Edinburgh, UK. Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Peissig Peggy L PL Marshfield Clinic Research Institute, Marshfield, WI, USA. Peloso Gina M GM Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Pennell Craig E CE School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia. Perola Markus M Estonian Genome Center, University of Tartu, Tartu, Estonia. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. National Institute for Health and Welfare, Helsinki, Finland. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland. Perry James A JA Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Pers Tune H TH Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. Person Thomas N TN Marshfield Clinic Research Institute, Marshfield, WI, USA. Peters Annette A German Center for Diabetes Research, Neuherberg, Germany. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Petersen Eva R B ERB Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark. Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Polasek Ozren O Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. School of Medicine, University of Split, Split, Croatia. Polderman Tinca J TJ Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands. Puolijoki Hannu H Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland. Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Rasheed Asif A Centre for Non-Communicable Diseases, Karachi, Pakistan. Rauramaa Rainer R Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Reilly Dermot F DF Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA. Renström Frida F Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden. Department of Biobank Research, Umeå University, Umeå, Sweden. Rheinberger Myriam M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Ridker Paul M PM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Harvard Medical School, Boston, MA, USA. Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Rioux John D JD Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. Rivas Manuel A MA Broad Institute of MIT and Harvard, Cambridge, MA, USA. Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. Roberts David J DJ NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NHS Blood and Transplant-Oxford Centre, Oxford, UK. BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Robertson Neil R NR Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Robino Antonietta A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Rolandsson Olov O Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden. Rudan Igor I Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. Saleheen Danish D Centre for Non-Communicable Diseases, Karachi, Pakistan. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Salomaa Veikko V National Institute for Health and Welfare, Helsinki, Finland. Samani Nilesh J NJ Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Sapkota Yadav Y QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Sattar Naveed N University of Glasgow, Glasgow, UK. Schoen Robert E RE Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Schreiner Pamela J PJ Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. Schulze Matthias B MB Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany. German Center for Diabetes Research, Neuherberg, Germany. Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Segura-Lepe Marcelo P MP Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Shah Svati H SH Duke Molecular Physiology Institute, Duke University, Durham, NC, USA. Sheu Wayne H-H WH Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. School of Medicine, National Defense Medical Center, Taipei, Taiwan. School of Medicine, National Yang-Ming University, Taipei, Taiwan. Sim Xueling X Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore. Slater Andrew J AJ Genetics, Target Sciences, GlaxoSmithKline, Research Triangle Park, NC, USA. OmicSoft at Qiagen Company, Cary, NC, USA. Small Kerrin S KS Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Smith Albert V AV Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Icelandic Heart Association, Kopavogur, Iceland. Southam Lorraine L Wellcome Trust Sanger Institute, Hinxton, UK. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Spector Timothy D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Speliotes Elizabeth K EK Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. Starr John M JM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland. deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Steinthorsdottir Valgerdur V deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Stirrups Kathleen E KE William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Department of Haematology, University of Cambridge, Cambridge, UK. Strauch Konstantin K Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany. Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. Stumvoll Michael M IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. Department of Medicine, University of Leipzig, Leipzig, Germany. Sun Liang L Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. Department of Public Health, University of Helsinki, Helsinki, Finland. Surendran Praveen P MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Swift Amy J AJ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA. Tada Hayato H Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Kanazawa University, Kanazawa, Japan. Tansey Katherine E KE MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK. College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK. Tardif Jean-Claude JC Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Taylor Kent D KD Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Thorleifsson Gudmar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, Iceland. deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. Thuesen Betina H BH Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark. Tönjes Anke A Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, Germany. Tromp Gerard G Weis Center for Research, Geisinger Health System, Danville, PA, USA. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Trompet Stella S Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. Tsafantakis Emmanouil E Anogia Medical Centre, Anogia, Greece. Tuomilehto Jaakko J National Institute for Health and Welfare, Helsinki, Finland. Centre for Vascular Prevention, Danube University Krems, Krems, Austria. Dasman Diabetes Institute, Dasman, Kuwait. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. Tybjaerg-Hansen Anne A Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Tyrer Jonathan P JP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. Uher Rudolf R Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada. Uitterlinden André G AG Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Uusitupa Matti M Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Laan Sander W SW Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Duijn Cornelia M CM Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Leeuwen Nienke N Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. van Setten Jessica J Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Vanhala Mauno M Primary Health Care Unit, Central Hospital of Central Finland, Jyväskylä, Finland. Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland. Varbo Anette A Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Varga Tibor V TV Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden. Varma Rohit R USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Velez Edwards Digna R DR Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA. Vermeulen Sita H SH Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Veronesi Giovanni G Research Center on Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy. Vestergaard Henrik H Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Steno Diabetes Center Copenhagen, Gentofte, Denmark. Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Vogt Thomas F TF Cardiometabolic Disease, Merck, Sharp & Dohme, Kenilworth, NJ, USA. Völker Uwe U German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. Vuckovic Dragana D Department of Medical Sciences, University of Trieste, Trieste, Italy. Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Wagenknecht Lynne E LE Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Walker Mark M Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle, UK. Wallentin Lars L Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Wang Feijie F Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Wang Carol A CA School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia. Wang Shuai S Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. Wang Yiqin Y Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Ware Erin B EB Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Warren Helen R HR William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Waterworth Dawn M DM Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, USA. Wessel Jennifer J Departments of Epidemiology and Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA. White Harvey D HD Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. Willer Cristen J CJ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA. Witte Daniel R DR Danish Diabetes Academy, Odense, Denmark. Department of Public Health, Aarhus University, Aarhus, Denmark. Wood Andrew R AR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. Wu Ying Y Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Yaghootkar Hanieh H Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. Yao Jie J Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Yao Pang P Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China. Yerges-Armstrong Laura M LM Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. GlaxoSmithKline, King of Prussia, PA, USA. Young Robin R MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. University of Glasgow, Glasgow, UK. Zeggini Eleftheria E http://orcid.org/0000-0003-4238-659X Wellcome Trust Sanger Institute, Hinxton, UK. Zhan Xiaowei X Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA. Zhang Weihua W Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK. Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Zhou Wei W http://orcid.org/0000-0002-8301-9297 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Zondervan Krina T KT http://orcid.org/0000-0002-0275-9905 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK. Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA. Pospisilik John A JA http://orcid.org/0000-0002-9745-0977 Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. Rivadeneira Fernando F http://orcid.org/0000-0001-9435-9441 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Borecki Ingrid B IB Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Deloukas Panos P http://orcid.org/0000-0001-9251-070X William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia. Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. Lettre Guillaume G Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada. North Kari E KE Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, USA. Lindgren Cecilia M CM Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK. Hirschhorn Joel N JN Broad Institute of MIT and Harvard, Cambridge, MA, USA. joelh@broadinstitute.org. Department of Genetics, Harvard Medical School, Boston, MA, USA. joelh@broadinstitute.org. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA. joelh@broadinstitute.org. Department of Pediatrics, Harvard Medical School, Boston, MA, USA. joelh@broadinstitute.org. Loos Ruth J F RJF Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ruth.loos@mssm.edu. CHD Exome+ Consortium EPIC-CVD Consortium ExomeBP Consortium Global Lipids Genetic Consortium GoT2D Genes Consortium EPIC InterAct Consortium INTERVAL Study ReproGen Consortium T2D-Genes Consortium MAGIC Investigators Understanding Society Scientific Group eng Published Erratum 2018 03 16

United States Nat Genet 9216904 1061-4036 Nat Genet. 2018 Jan;50(1):26-41 29273807 2018 3 18 6 0 2018 3 20 6 0 2018 3 20 6 0 aheadofprint 29549329 10.1038/s41588-018-0050-y 10.1038/s41588-018-0050-y 29547466 2018 03 16

1537-2677 2018 Mar 14 Ophthal Plast Reconstr Surg Dermalive Facial Filler Granulomas Masquerading as Neurofibromas. 10.1097/IOP.0000000000001100 A 56-year-old woman presented with periocular nodules that were clinically suspected to be neurofibromas. Histopathologic examination of excised nodules revealed a pronounced granulomatous reaction to a foreign material that was composed of glossy polygonal palely eosinophilic fragments. These fragments were outlined in red with Masson trichrome, stained gray with the elastic stain, and were uniformly red with Gomori methenamine silver staining. The histopathologic appearance was consistent with a granulomatous reaction to Dermalive facial filler. Postoperatively the patient admitted that she had filler injections many years earlier in another country, and that nodules appeared 1 year after injection. Treatment with steroids, intralesional immunosuppressive agents and surgery had been previously attempted to eradicate the nodules. The literature pertaining to granulomatous reactions to Dermalive and related hybrid facial fillers is reviewed and treatment options are discussed. This report is the first to illustrate the unique histopathologic staining characteristics of Dermalive, which may be useful to ophthalmic pathologists in identifying this uncommon foreign material. Wolkow Natalie N David G. Cogan Laboratory of Ophthalmic Pathology and Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Jakobiec Frederick A FA David G. Cogan Laboratory of Ophthalmic Pathology and Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Yoon Michael K MK David G. Cogan Laboratory of Ophthalmic Pathology and Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. eng Journal Article 2018 03 14

United States Ophthal Plast Reconstr Surg 8508431 0740-9303 2018 3 17 6 0 2018 3 17 6 0 2018 3 17 6 0 aheadofprint 29547466 10.1097/IOP.0000000000001100 29539278 2018 03 16 2018 03 16

1533-4406 378 11 2018 03 15 N. Engl. J. Med. A New Frontier in Curing Corneal Blindness. 1057-1058 10.1056/NEJMe1800726 Dana Reza R From the Massachusetts Eye and Ear Infirmary, Harvard Medical School Department of Ophthalmology, Boston. eng Editorial Comment

United States N Engl J Med 0255562 0028-4793 AIM IM N Engl J Med. 2018 Mar 15;378(11):995-1003 29539291 Blindness Cornea Corneal Diseases 2018 3 15 6 0 2018 3 15 6 0 2018 3 17 6 0 ppublish 29539278 10.1056/NEJMe1800726 29538184 2018 03 14

1531-7021 2018 Mar 13 Curr Opin Ophthalmol Sutureless transscleral fixation of secondary intraocular lenses. 10.1097/ICU.0000000000000474 The surgical approach to eyes needing a secondary intraocular lens have evolved rapidly in recent years. Here, we will focus on techniques for scleral-fixation of intraocular lenses (IOLs), and will review the evidence for their safety and efficacy. Transscleral fixation of IOLs refers the placement of lens haptics within scleral tunnels to stabilize the lens in eyes that lack adequate capsular support. Various surgical techniques have been reported recently to accomplish this goal. These include the use of a trocar, microvitreoretinal blade, or hypodermic needle to create the scleral tunnels, as well as several methods for placing the haptics through the tunnels. Although long-term data is lacking, each technique has been shown to have good visual outcomes without significant side effects. Surgical approaches for the transscleral fixation of secondary IOLs provide a safe and effective technique for the management of eyes with insufficient capsular support. Nudleman Eric E Department of Ophthalmology, Shiley Eye Institute and Jacobs Retina Center, University of California San Diego, La Jolla, California. Yonekawa Yoshihiro Y Department of Ophthalmology, Mass Eye and Ear and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Prenner Jonathan L JL Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School. NJ Retina, New Brunswick, New Jersey, USA. eng Journal Article 2018 03 13

United States Curr Opin Ophthalmol 9011108 1040-8738 2018 3 15 6 0 2018 3 15 6 0 2018 3 15 6 0 aheadofprint 29538184 10.1097/ICU.0000000000000474 29528979 2018 03 16

1539-2864 2018 Mar 08 Retina (Philadelphia, Pa.) SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN COATS DISEASE. 10.1097/IAE.0000000000002120 To evaluate microstructural retinal abnormalities on spectral domain optical coherence tomography (SD-OCT) imaging of eyes with Coats disease. This is a multicenter, retrospective study in which SD-OCT images of patients with treatment-naive Coats disease were correlated with clinical examination and visual acuity and, when available, followed longitudinally over time. Macular SD-OCT of 27 eyes with Coats disease revealed intraretinal edema (59%), intraretinal exudates (67%), subretinal fluid (37%), subretinal exudate (48%), ellipsoid zone disruption (52%), external limiting membrane disruption (41%), and subfoveal nodule (26%). All these microstructural abnormalities correlated with worse baseline and final visual acuities (P < 0.05) on univariate analysis, except for intraretinal edema which exhibited a nonstatistically significant trend toward worse baseline visual acuity (P = 0.16). Within stage 2b eyes, external limiting membrane disruption and subretinal nodule on SD-OCT were associated with worse baseline visual acuity (P = 0.02 for both), and there was a trend toward worse final visual acuity with external limiting membrane disruption and subretinal nodule (P = 0.17 for both) and worse baseline (P = 0.08) and final (P = 0.13) visual acuities with ellipsoid zone disruption. No microstructural abnormalities were noted on OCT of fellow eyes. Spectral domain OCT can identify microstructural abnormalities in Coats disease that are associated on univariate analysis with worse baseline visual acuity and visual prognosis. Further larger studies are necessary. Gupta Mrinali P MP Department of Ophthalmology, Weill Cornell Medical College, New York, New York. Dow Eliot E Department of Ophthalmology, Weill Cornell Medical College, New York, New York. Jeng-Miller Karen W KW Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Mukai Shizuo S Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Orlin Anton A Department of Ophthalmology, Weill Cornell Medical College, New York, New York. Xu Kunyong K Department of Ophthalmology, Weill Cornell Medical College, New York, New York. Yonekawa Yoshihiro Y Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Chan R V Paul RVP Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois. eng P30 EY001792 EY NEI NIH HHS United States R01 EY019474 EY NEI NIH HHS United States Journal Article 2018 03 08

United States Retina 8309919 0275-004X 2018 3 13 6 0 2018 3 13 6 0 2018 3 13 6 0 aheadofprint 29528979 10.1097/IAE.0000000000002120 29526339 2018 03 28

1873-4502 44 2 2018 Feb J Cataract Refract Surg Quantitative analysis of corneal stromal riboflavin concentration without epithelial removal. 237-242 S0886-3350(18)30100-7 10.1016/j.jcrs.2018.01.010 To compare the corneal stromal riboflavin concentration and distribution using 2 transepithelial corneal crosslinking (CXL) systems. Absorption Systems, San Diego, California, USA. Experimental study. The stromal riboflavin concentration of 2 transepithelial CXL systems was compared in rabbit eyes in vivo. The systems were the Paracel/Vibex Xtra, comprising riboflavin 0.25% solution containing TRIS and ethylenediaminetetraacetic acid and an isotonic solution of riboflavin 0.25%, (Group 1) and the CXLO system (Group 2). Manufacturers' Instructions For Use were followed. The intensity of riboflavin fluorescence by slitlamp observation 10, 15, and 20 minutes after instillation was graded on a scale of 0 to 5. The animals were humanely killed and the corneal stromal samples analyzed with liquid chromatography and mass spectrometry. The mean riboflavin fluorescence intensity grades in Group 1 (4 eyes) were 3.8, 4.8, and 4.8 at 10, 15, and 20 minutes, respectively. The mean grades in Group 2 (3 eyes) were 2.0, 2.3, and 2.0, respectively. The riboflavin distribution was uniform in Group 1 but not in Group 2. The mean riboflavin concentration by liquid chromatography and mass spectrometry was 27.0 μg/g stromal tissue in Group 1 and 6.7 μg/g in Group 2. A stromal riboflavin concentration theoretically adequate for CXL, 15 μg/g, was achieved in all eyes in Group 1 and no eyes in Group 2. Slitlamp grading correlated well with liquid chromatography and mass spectrometry concentration (R² = 0.940). The system used in Group 1 produced corneal riboflavin concentrations that were theoretically adequate for effective transepithelial CXL (≥15 μg/g), while the system in Group 2 did not. Slitlamp grading successfully estimated the corneal riboflavin concentration and can be used to ensure an adequate concentration of riboflavin in the cornea for transepithelial CXL. Copyright © 2018 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. Rubinfeld Roy S RS From the Department of Ophthalmology (Rubinfeld), Georgetown University Medical School/Washington Hospital Center, Washington, DC, Re:Vision Private Practice (Rubinfeld), Rockville, Maryland, the Stulting Research Center (Stulting), Woolfson Eye Institute, Atlanta, Georgia, Absorption Systems (Gum), San Diego, California, and the Massachusetts Eye and Ear Infirmary and Harvard Medical School (Talamo), Boston, Massachusetts, USA. Electronic address: doctor@revisedeye.com. Stulting R Doyle RD From the Department of Ophthalmology (Rubinfeld), Georgetown University Medical School/Washington Hospital Center, Washington, DC, Re:Vision Private Practice (Rubinfeld), Rockville, Maryland, the Stulting Research Center (Stulting), Woolfson Eye Institute, Atlanta, Georgia, Absorption Systems (Gum), San Diego, California, and the Massachusetts Eye and Ear Infirmary and Harvard Medical School (Talamo), Boston, Massachusetts, USA. Gum Glenwood G GG From the Department of Ophthalmology (Rubinfeld), Georgetown University Medical School/Washington Hospital Center, Washington, DC, Re:Vision Private Practice (Rubinfeld), Rockville, Maryland, the Stulting Research Center (Stulting), Woolfson Eye Institute, Atlanta, Georgia, Absorption Systems (Gum), San Diego, California, and the Massachusetts Eye and Ear Infirmary and Harvard Medical School (Talamo), Boston, Massachusetts, USA. Talamo Jonathan H JH From the Department of Ophthalmology (Rubinfeld), Georgetown University Medical School/Washington Hospital Center, Washington, DC, Re:Vision Private Practice (Rubinfeld), Rockville, Maryland, the Stulting Research Center (Stulting), Woolfson Eye Institute, Atlanta, Georgia, Absorption Systems (Gum), San Diego, California, and the Massachusetts Eye and Ear Infirmary and Harvard Medical School (Talamo), Boston, Massachusetts, USA. eng Journal Article 2018 03 08

United States J Cataract Refract Surg 8604171 0886-3350 2017 10 26 2018 01 26 2018 01 26 2018 3 13 6 0 2018 3 13 6 0 2018 3 13 6 0 ppublish 29526339 S0886-3350(18)30100-7 10.1016/j.jcrs.2018.01.010 29525602 2018 03 11

1549-4713 2018 Mar 07 Ophthalmology Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema. S0161-6420(17)32232-7 10.1016/j.ophtha.2018.01.019 To assess systemic vascular endothelial growth factor (VEGF)-A levels after treatment with intravitreous aflibercept, bevacizumab, or ranibizumab. Comparative-effectiveness trial with participants randomly assigned to 2 mg aflibercept, 1.25 mg bevacizumab, or 0.3 mg ranibizumab after a re-treatment algorithm. Participants with available plasma samples (N = 436). Plasma samples were collected before injections at baseline and 4-week, 52-week, and 104-week visits. In a preplanned secondary analysis, systemic-free VEGF levels from an enzyme-linked immunosorbent assay were compared across anti-VEGF agents and correlated with systemic side effects. Changes in the natural log (ln) of plasma VEGF levels. Baseline free VEGF levels were similar across all 3 groups. At 4 weeks, mean ln(VEGF) changes were -0.30±0.61 pg/ml, -0.31±0.54 pg/ml, and -0.02±0.44 pg/ml for the aflibercept, bevacizumab, and ranibizumab groups, respectively. The adjusted differences between treatment groups (adjusted confidence interval [CI]; P value) were -0.01 (-0.12 to +0.10; P = 0.89), -0.31 (-0.44 to -0.18; P < 0.001), and -0.30 (-0.43 to -0.18; P < 0.001) for aflibercept-bevacizumab, aflibercept-ranibizumab, and bevacizumab-ranibizumab, respectively. At 52 weeks, a difference in mean VEGF changes between bevacizumab and ranibizumab persisted (-0.23 [-0.38 to -0.09]; P < 0.001); the difference between aflibercept and ranibizumab was -0.12 (P = 0.07) and between aflibercept and bevacizumab was +0.11 (P = 0.07). Treatment group differences at 2 years were similar to 1 year. No apparent treatment differences were detected at 52 or 104 weeks in the cohort of participants not receiving injections within 1 or 2 months before plasma collection. Participants with (N = 9) and without (N = 251) a heart attack or stroke had VEGF levels that appeared similar. These data suggest that decreases in plasma free-VEGF levels are greater after treatment with aflibercept or bevacizumab compared with ranibizumab at 4 weeks. At 52 and 104 weeks, a greater decrease was observed in bevacizumab versus ranibizumab. Results from 2 subgroups of participants who did not receive injections within at least 1 month and 2 months before collection suggest similar changes in VEGF levels after stopping injections. It is unknown whether VEGF levels return to normal as the drug is cleared from the system or whether the presence of the drug affects the assay's ability to accurately measure free VEGF. No significant associations between VEGF concentration and systemic factors were noted. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. Jampol Lee M LM Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Glassman Adam R AR Jaeb Center for Health Research, Tampa, Florida. Liu Danni D Jaeb Center for Health Research, Tampa, Florida. Electronic address: drcrstat7@jaeb.org. Aiello Lloyd Paul LP Joslin Diabetes Center, Beetham Eye Institute, Harvard Department of Ophthalmology, Boston, Massachusetts. Bressler Neil M NM Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Duh Elia J EJ Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Quaggin Susan S Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Wells John A JA Palmetto Retina Center, Columbia, South Carolina. Wykoff Charles C CC Retina Consultants of Houston, Blanton Eye Institute, Houston, Texas. Diabetic Retinopathy Clinical Research Network eng Journal Article 2018 03 07

United States Ophthalmology 7802443 0161-6420 Browning David D Antoszyk Andrew N AN Price Angela K AK Fredenberg Sherry L SL Herby Jenna T JT Fleming Christina J CJ McClain Ashley A AA Ennis Sarah A SA Gallagher Kelly R KR Karow Angella S AS Grupp Autumn C AC Puskas Danielle D Watson Lynn L Bojaj Swann J SJ Balasubramaniam Uma M UM McClain Donna D Styles Donna R DR Kuopus Jeff A JA Kimrey Kathryn K Clark Loraine M LM Jackson Lisa A LA McOwen Michael D MD Dunlap Matt M Held Susannah J SJ Pieramici Dante J DJ Nasir Ma'an A MA Castellarin Alessandro A AA Dhoot Dilsher D Fishbein Sarah S Giust Jack J Wan Lisha L Hanna Michelle S MS Rabena Melvin D MD Smith Jerry J Bone Layne J LJ Avery Kelly K Giust Matthew M Walker Aimee A Shook Aimee H AH Esau Sara S Ruvalcaba Nitce L NL Wells John A JA Clark W Lloyd WL Johnson David L DL Payne John F JF Swinford Tiffany R TR Taylor Mallie M MM Garrison Cassandra L CL Miller Peggy D PD Houlahan Amber R AR O'Neill Charlotte A CA Floyd Ashley A Parker Crystal C CC Sease Courtney C Graham Tara T Spencer Robin R Ogbuewu Tiffany N TN Studebaker Ashley A Huggins Tyler T Spivey Robbin R Jones Brian B Williams Ashley A Petty Ron R Poston Erin L EL Ward G Michael GM Baker Carl W CW Tilford Ron H RH Caldwell Tracey M TM Lambert Lynnette F LF Palmer Mary J MJ Martin Tracey R TR Williams Tana R TR Kettler Samantha S Camp Alecia B AB Silva Paolo S PS Arrigg Paul G PG Sharuk George S GS Shah Sabera T ST Sun Jennifer K JK Westerfeld Corey C Andreoli Christopher Michael CM Aiello Lloyd Paul LP Schlossman Deborah D Murtha Timothy T Kwak Hanna H Flores Flor M FM Stockman Margaret E ME Kieser Troy T Krigman Michael N MN Bestourous Leila L Weimann Elizabeth S ES Cavallerano Jerry D JD Hock Kristen M KM Robertson Mary Ann MA Kirby Rita K RK Papaconstantinou Steve L SL Madigan Kylie M KM Cavicchi Robert W RW Palitsch Kate A KA Yilmaz Taygan T Berger Brian B BB Jhaveri Chirag D CD Moore Tori T Manhart Ginger J GJ Walsh Rachel A RA Gunderson Ivana I Riepen Dietrich D Bravenec Chelsey A CA Reid Ryan M RM Ren Yong Y Ostrander Ben B Stovall Christopher C CC Elman Michael J MJ Liss Robert A RA Leder Henry A HA Starr JoAnn J Belz Jennifer L JL Putzulo Charlene K CK Sandler Dallas R DR Simmons Jennifer L JL Singletary Pamela V PV Davis Ashley A Simpson Perel M PM Coffey Teresa T Ketner Daniel J DJ Cain Terri T Metzger Ashley M AM Sotirakos Peter P Elman Michael J MJ Liss Robert A RA Leder Henry A HA Starr JoAnn J Belz Jennifer L JL Putzulo Charlene K CK Sandler Dallas R DR Simmons Jennifer L JL Singletary Pamela V PV Davis Ashley A Simpson Perel M PM Coffey Teresa T Ketner Daniel J DJ Cain Terri T Metzger Ashley M AM Sotirakos Peter P Marcus Dennis M DM Singh Harinderjit H Roberts Courtney N CN Floyd Geri L GL Ortiz Siobhan O SO Mims Virginia V Foster L Allison LA Coursey Christy C Gardner Jared C JC Ivey Ken K O'Keefe John Stewart JS Astruc Juan A JA Schwent Bryan J BJ Tabassian Ali R AR Rosen Suzette A SA Vaughan David C DC Michaels Jeffrey J Arndt Natalie J NJ Maziarz John J JJ Friedman Scott M SM Moinfar Nader N Williamson Kimberly A KA Fagan Damanda F DF Dawson Katrina L KL Walters Paige N PN McKinney Allen A Carlton Steve S Kwun Robert C RC Knudsen Victoria L VL Winward Kirk E KE Swartz Mano M Howard James G JG Riley Michelle M Taylor Gena G Holt Michelle M Winward Jason G JG Walsh Adam A Taylor Teresa T Walsh Daniel D Hampton G Robert GR Brown Jamin S JS Seth Rajeev K RK Sienkiewycz Laurie J LJ Appleton Deborah A DA Grinnell Cindy J CJ Cowley Charity A CA Kwasniewski Lynn M LM Manley Michelle L ML Robarge Nicole E NE DeSantis Stefanie R SR Hay Peter B PB DeForge Teresa M TM Wykoff Charles C CC Wong Tien P TP Chen Eric E Brown David M DM Kim Rosa Y RY Major James C JC Schefler Amy C AC Fish Richard H RH Benz Matthew S MS Lipman Meredith M Hutson Amy A Landaverde Nubia N Chancey Ashley E AE Cone Cassie C Royse Tressa T Sneed Veronica A VA Almanza Belinda A BA Dives Brenda B Richter Beau A BA Kegley Eric N EN Lauer Andreas K AK Flaxel Christina J CJ Bailey Steven T ST Schain Mitchell M Lundquist Ann D AD Hanel Shelley A SA Ira Shirley D SD Nolte Susan K SK Steinkamp Peter N PN Ryan Dawn M DM Pickell Scott R SR Hui Jocelyn T JT Brix Michelle M Barth Jordan J Howell Chris S CS Fox Gregory M GM Cooper Blake A BA Batlle Ivan R IR Manning Lexie R LR Batlle Karla A KA Wyrick Holly H Pippin Katherine K Perkins Samantha S Yeager Frank T FT Rush Ryan B RB Gardner Glenn R GR Rush Christi C Hawkins Johnathan R JR Dumas Brenda B Ysasaga Ben B Shah Chirag P CP Morley Michael G MG Wiegand Torsten W TW Cleary Tina S TS Topping Trexler M TM Colegrove Lindsey L Bechtel Katharine K Johnson Britta B Lebedew Lisa L Lorius Natacha N Chong Sandy G SG Stone Jennifer L JL Jones Michael Cullen MC Donovan Dennis D Malone Sherry S Graham Margie M Santos Audrey A Bennett Steve A SA Blinder Kevin J KJ Smith Bradley T BT Nobel Ginny S GS Weeks Rhonda F RF Hoehn Erika A EA Stuart Maria A MA Pepple Kelly E KE Boyd Lynda K LK Pulliam Brook G BG Schremp Steve A SA Guevara Stephanie L SL Wehmeier Jarrod J Wright Timothy L TL Gabel Dana L DL Miller David G DG Schartman Jerome P JP Singerman Lawrence J LJ Coney Joseph M JM Novak Michael A MA Rao Llewelyn J LJ Rath Susan C SC McNamara Elizabeth E Stone Larraine L Smith Veronica A VA Rykena Cecelia C DuBois Kimberly A KA Ilc Mary A MA Tanner Vivian V Drury Kim K Nitzsche Trina M TM Greanoff Gregg A GA DuBois John C JC Burgess Stuart K SK Lara Tirso M TM Pereda Noel H NH Fernandez Cindy V CV Davis Deborah D Quinchia Evelyn E Workman Karen K Nielsen Jared S JS Sohn Jeong-Hyeon JH Alliman Kyle J KJ Saggau David D DD Parker Marianne M George Bethany B Eastvold Carrie L CL Sells Kristin K Woehl Tami Jo TJ Johnson Marilyn A MA Keenan Holly H Coleman Jennifer L JL Spillman Jamie J Freeman Shannon S Schmidt Leigh S LS Boender Lisa M LM Partin Jill L JL Bennett Bailey R BR Rostvold Jay J McLure Stone Cameron C Raymer Lea R LR Menzel Andrea K AK Rickman Leslie D LD Campbell Barbara B Sherlin Lorraine P LP Hawkins Lisa H LH Buckner Melissa L ML Matsipura Olesya N ON Price Paula A PA Ghuman A Thomas AT Raskauskas Paul A PA Sharma Ashish G AG Wing Glenn G Walker Joseph P JP Knips Eileen E Kiesel Cheryl C Peters Crystal Y CY Ryan Cheryl C Greenhoe Laura L Torres Natalie N NN Youngblood Rebecca J RJ Turnbo Danielle D Leslie Anita H AH Schoeman Etienne C EC Kiesel Raymond K RK Kingsley Ronald M RM Shah Vinay A VA Leonard Robert E RE Miller Heather R HR Icks Sonny S Bergman Vanessa A VA Drummond Vanessa K VK Ross Brittany L BL Ellis Reshial D RD Whittington Tina R TR Almeida Shannon R SR Butt Amanda M AM Burris Russ R Peters Mark A MA Lee Michael S MS Tlucek Paul S PS Ma Colin C Hobbs Stephen S Milliron Amanda C AC Ho Stephanie L SL Kopfer Marcia M Logan Joe J Hoerner Christine C Khawly Joseph A JA Rahman Hassan T HT Abdelgani Diana D Miller Pam S PS Fredrickson Debbie D Pineda Erica E Lopez Desiree D Lowd Donald K DK Blank Colin C Martinez Lorena R LR Muniz Jason E JE Gottlieb Justin J Ip Michael S MS Blodi Barbara A BA Dietzman Kristine A KA Burke Kathryn F KF Smith Christopher M CM Olson Shelly R SR Wealti Angela M AM Reed Sandie L SL Krolnik Denise A DA Peterson John C JC Gonzalez Victor Hugo VH Diaz-Rohena Roberto R Santiago Juan G JG Adyanthaya Rohit R Patel Nehal R NR Anaya Deyla D Garcia Dina D Cruz Edna E EE Alvarez Crystal A CA Iracheta Ruth R Rodriguez Jessica J Cantu Monica R MR Flores Rebecca R RR Jasso Hector H Rodriguez Rachel R Miranda Karina K Lozano Krystle R KR Garza Maricela M Aguero Lazaro L Sandoval Amanda L AL Montemayor Monique M Alonso Samuel S Garza Santos S DiLoreto David Allen DA Ramchandran Rajeev S RS Kleinman David M DM O'Gara George W GW Czubinski Andrea M AM MacDowell Peter P Steinmetz Kari M KM Castillo Dan A DA Yu Yvonne F YF Tongue Salina M SM Keim Melissa S MS Hollar Rachel R Deats Brandi N BN Richardson Brittany S BS Singer Lynn L Pannell Taylor A TA Daniels Stewart A SA Ranchod Tushar M TM Leong Craig J CJ Touson Stacey S Earl Shannon R SR Bartlett Melissa C MC Fernando Christine C Factor Djorella D Garcia Jessica J Nguyen Anna K AK Hom Betty B Walker Cathy C Marudo Grace M GM Suazo Jose Carlos JC McNeil Leah M LM Hanamoto Fred F Hughes Matthew D MD Ross Robin D RD Sanford Susan M SM Markiewicz Nicole Martini NM Utley Tracy M TM Henderson Shannon S Lippincott Joanie H JH Streasick Patricia P Glazer Louis C LC Garber Frank W FW Zheutlin Jeffrey D JD Listerman Angela D AD Feehan Christine E CE Cruz Heather L HL Kuitula Donald E DE Rainey Olivia P OP Weatherbee Sue S Googe Joseph M JM Shuler R Keith RK Anderson Nicholas G NG Perkins Stephen L SL Oliver Kristina K Grindall Nicole N Arnold Ann A Beerbower Jennifer J Hunt Cecile C Schulz Kathy L KL Oelrich Sarah M SM Whetstone Jerry K JK Walsh Justin J Morris Chris C Wong Robert W RW Nixon Peter A PA Leon Jeni L JL Montesclaros Chris A CA Leung Carrie E CE Le Phill P Harborth Codey L CL Rodriguez Margaret A MA Mangham Cory C Aaberg Thomas M TM Westhouse Scott J SJ Vincent Holly L HL Malone Rebecca R Karsten Kathy L KL Maturi Raj K RK Harless Ashley M AM Novak Carolee K CK Bleau Laura A LA Steele Thomas T Harris Charlotte C Bildner Alisha A Maple Abby A Stone Thomas W TW Isernhagen Rick D RD Kitchens John W JW Holcomb Diana M DM Van Arsdall Jeanne J Buck Michelle M Slade Edward A EA Chiu Mark T MT Reddy Ashok K AK Wyant Frank W FW Montano-Niles Mary M MM Carter Lorraine J LJ Maerki Shirley S Tartaglia Laura L Gomez Paul P PP Maestas Stephen A SA Shanta Camille C Jimenez Lisbrenda M LM Stoltz Robert A RA Vanderveldt Stephanie L SL Lampert Scott I SI Marcus Leslie G LG Fulbright Shelly S Martin James P JP Novack Roger L RL Liao David S DS Lo Tammy Eileen TE Kurokouchi Janet J Ngo Richard R Hoang Connie V CV Sierra Julio J Zamboni Adam A Protacio Eric G EG Kessinger Jeff J Garg Seema S Houghton Odette M OM Ulrich Jan Niklas JN Chavala Sai H SH DuBose Elizabeth L EL Barnhart Cassandra J CJ Karmalkar Megha M Jani Pooja D PD Goble Justin J Cantrell Debra D Esquejo Rona Lyn RL Shah Sandeep N SN Harmon Natasha N Dhalla Mandeep S MS Del Cid Mario R MR Halperin Lawrence S LS Brady Jaclyn A JA Hamlin Monica M Lopez Monica L ML Mariano Jamie J Neale Candace M CM Veksler Rita R RR Mannarelli Angelica A Coffee Robert E RE Carvounis Petros Euthymiou PE Hemati Pejman P Dorenbach Cindy J CJ Joshi Annika S AS Leger April A Barnett Dana B DB Morales Joseph F JF Mansour Sam E SE Choyce Cathy C Dirawatun Aissa L AL Nagy Emma A EA Kerkstra Jamie C JC Fan Joseph T JT Suthar Mukesh Bhogilal MB Rauser Michael E ME Santiago Gisela G Marvyn Cerdenio Liel L Perez Brandi J BJ Halsey Kara E KE Kiernan William H WH Knabb Jesse J Catren Rachel R Shami Michel M Arrington Brenda K BK Neuling Keri S KS Meeks Ashaki A Garcia Natalie R NR Blair Kayla K Rhymes Ginger K GK Medrano Janet J Kim Judy E JE Weinberg David V DV Stepien Kimberly E KE Connor Thomas B TB Williams Vesper V VV Kaczanowski Tracy L TL Packard Krissa L KL Flanders Judy J Barwick Vicki V Winter Pat A PA Beringer Joseph R JR Selchert Kathy J KJ Lehr John T JT Rodriguez-Roman Elaine E Jones Teri T Haddox Martha Eileen ME Pena Mark M Hernandez Brenda B Chan Clement K CK Lalezary Maziar M Lin Steven G SG Walther Kimberly S KS Gonzales Tiana T Myers Lenise E LE Huff Kenneth M KM Chace Richard R Kallay Sunny S Stevens Kirsten K Dolbec Nicole N Baker-Hill Ronda R Surette Janea J Rose Steven J SJ Connolly Brian P BP Guillet Ernest G EG Hall Edward F EF Yagoda Margaret M MM Doran Mary Jo MJ Burgess Mindy M Reynard Ann A Powers Margaret M Territo Joe J Mein Calvin E CE Chica Moises A MA Lane R Gary RG Holy Sarah Elizabeth SE Kirschbaum Lita L Martinez Vanessa D VD Baker Jaynee J Kincaid Christa G CG Castillo Elaine E Wienecke Christopher Sean CS Schlichting Sara L SL Nakoski Brenda B Diddie Kenneth R KR Cadwell Deborah M DM Van Arsdale Louise L Boisvert Taryn F TF Galonsky Joyce J O'Hayer Susie S Johnson Melissa L ML McCabe Frank J FJ Baker Brad J BJ Defrin Melvyn H MH Lampson Marie V MV Pratte Heather H Baron Selena A SA Borelli Aundrea S AS Davidorf Frederick H FH Wells Michael B MB Chang Susie S Christoforidis John Byron JB Letson Alan D AD Salerno Jill A JA Perry Jerilyn G JG Shelley Stephen E SE Fish Patrick J PJ Scott Michael H MH Dixon James A JA Walsh Shannon R SR Ozpirincci Philomina M PM Tebon Brenda L BL Moyle Marcia J MJ Pavlica Michael R MR Matta Noelle S NS Brubaker Cristina M CM Backer Alyson B AB Bhagat Neelakshi N Fay Catherine C Mikheyeva Tatiana T Lazar Michael M Ellenberger Janie D JD Malpica Beth B Brucker Alexander J AJ Kim Benjamin J BJ VanderBeek Brian L BL Drossner Sheri S DuPont Joan C JC Salvo Rebecca R Engelhard Stephanie B SB Berger Jim M JM Morales Sara S Serpentine Beth B Kaufman Paul L PL McCluskey Jessica D JD Wynne Kathy T KT Jordan Julian J Watson Brandun B Wirthlin Robert S RS Guglielmo Eric S ES Dittman Eileen A EA Waidelich Dylan C DC Garza Cristofer J CJ Stone Adeline M AM Oakes Ashley Nicole AN Suner Ivan J IJ Hammer Mark E ME Peden Marc C MC Traynom Janet R JR DenBoer Rochelle R Vargo Heidi H Ramsey Susan S Malzahn Anita Kim AK Jeffres Debra D Chaudhry Nauman A NA Shah Sumit P SP Haffner Gregory M GM German Emiliya E Moreau Shannan S Fox Laura A LA Matteson Jennifer M JM Pelletier JoAnna L JL Fontecchio Alison A Morse Emily E McNamara Greg G Laglivia Marie Grace MG Scherf Marissa L ML LaPre Angela A Cocilo Justin A JA Das Arup A Friesen Linda L Franco Michele M Lucero Johnny J Frazier Melissa M Laviolette Robert R Mian Umar Khalil UK Riemer Rebecca L RL Koestenblatt Evelyn E Wolf Louise V LV Kim Christine C Katkovskaya Irina I Otoo Erica E Ellerbe Kevin A KA Boyd Kenneth K Costa Caroline C Edwards Paul Andrew PA Gao Hua H Hessburg Thomas T Desai Uday U Murphy Janet J Monk Mary K MK Hall Julianne J Mazurek Melina M Ventimiglia Katie M KM Rusinek Brian A BA Stern Bradley A BA Brouhard Kris K Weier Katie M KM Allis Megan M Shaken Jenny J Massu Nicole M NM Troszak Tracy A TA Burley David D Bhavsar Abdhish R AR Emerson Geoffrey G GG Jones Jacob M JM Anderson Tracy A TA Gilchrist Andrea A Peloquin Matt D MD Gaid Gaid G Vang Yang Y Ryan Samantha S Vang Denise D Evans Alanna C AC Scherer Tonja T Lazarus Howard S HS Bunch Debra Paige DP Davis Liana C LC Booth Kelly K Trimble Margaret M Bledsaw Mary A MA Moore Jay J Rosberger Daniel F DF Groeschel Sandra S Madry Miriam A MA DiGirolamo Nikoletta N Pressley Dustin D Santora Robert R Gomez Yenelda M YM Olsen Karl R KR Bergren Robert L RL Conrad P William PW Rath Pamela P PP Vyas Avni Patel AP Liu Judy C JC Merlotti Lori A LA Chamberlin Jennifer L JL Mechling Holly M HM Kelly Mary E ME Marfisi Kellianne K Yeckel Kimberly A KA Bennett Veronica L VL Schultz Christina M CM Rigoni Grace A GA Walter Julie J Forish Missy A MA Fec Amanda A Foreman Courtney L CL Steinberg David D McBroom Keith D KD Chen Melvin C MC Levy Marc H MH Torres Waldemar W Jelemensky Peggy P Raphael Tara L TL Rich Joann J Sneath Mark M Kinyoun James L JL Vemulakonda Gurunadh Atmaram GA Rath Susan A SA Ernst Patricia K PK Pettingill Juli A JA Jones Ronald C RC Clifton Brad C BC Leslie James D JD Solomon Sharon D SD Bressler Neil M NM Levin Lisa K LK Donohue Deborah D Frey Mary M Larez Lorena L Murray Keisha K Denbow Rita L RL Graul Janis J Emmert David D Herring Charles C Rhoton Nick N Belz Joe J Lyon Alice T AT Mirza Rukhsana G RG Krug Amanda M AM Ramirez Carmen C Kaminski Lori L Castro-Malek Anna Liza M ALM Mills Amber N AN Rozenbajgier Zuzanna Z Skelly Marriner L ML Simjanoski Evica E Degillio Andrea R AR Lim Jennifer I JI Chau Felix Y FY Niec Marcia M Johnson Tametha T Ovando Yesenia Y Janowicz Mark M Carroll Catherine C Gross Jeffrey G JG Fishburne Barron C BC Flowers Amy M AM Stroman Riley R Ochieng Christen C McDowell Angelique S A ASA Paul Ally M AM Price Randall L RL Drouilhet John H JH Lacaden Erica N EN Nobler Deborah J DJ Cummings Howard L HL Long Deanna Jo DJ McCord Ben B Robinson Jason J Swift Jamie J Maynard Julie P JP Pahk Patricia J PJ Palmer-Dwore Hannah H Dave Dipali H DH Pacheco Mariebelle M Galati Barbara A BA Simpson Eneil E Barkmeier Andrew J AJ Vogen Diane L DL Berg Karin A KA Howard Shannon L SL Burrington Jean M JM Morgan Jessica Ann JA Overend Joan T JT Goddard Shannon S Lewison Denise M DM Tesmer Jaime L JL Greven Craig Michael CM Fish Joan J Everhart Cara C Clark Mark D MD Miller David T DT Hubbard George Baker GB Yan Jiong J Cribbs Blaine E BE Curtis Linda T LT Brower Judy L JL Dobbs Jannah L JL Jordan Debora J DJ Ahmad Baseer U BU Huang Suber S SS Sedlacek Hillary M HM Hornsby Cherie L CL Ferguson Lisa P LP Carlton Kathy K Sholtis Kelly A KA Allchin Peggy P Clow Claudia C Harrod Mark A MA Pankhurst Geoffrey G Baum-Rawraway Irit I Hrvatin Stacie A SA Gentile Ronald C RC Yang Alex A Carrasquillo-Boyd Wanda W Masini Robert R Samy Chander N CN Kraut Robert J RJ Shirley Kathy K Corso Linsey L Ely Karen K Scala Elizabeth E Gross Stewart S Alava Vanessa V Margalit Eyal E Neely Donna G DG Blaiotta Maria M Hagensen Lori L Harris April E AE Lennon Rita L RL Cota Denice R DR Wilson Larry L Wells John A JA 3rd Aiello Lloyd P LP Beck Roy W RW Bressler Neil M NM Bressler Susan B SB Chalam Kakarla V KV Danis Ronald P RP Arnold-Bush Bambi J BJ Ferris Frederick F Friedman Scott M SM Glassman Adam R AR Scott Michael H MH Sun Jennifer K JK Wong Robert W RW Glassman Adam R AR Beck Roy W RW Almukhtar Talat T Arnold-Bush Bambi J BJ Dale Brian B BB Baptista Alyssa A Connor Crystal C Conner Jasmine J Constantine Sharon R SR Dowling Kimberly K Dupre Simone S SS Ayala Allison R AR Huggins Meagan L ML Inusah Seidu S Johnson Paula A PA Loggins Brenda L BL McClellan Shannon L SL Melia Michele M Battle Eureca E Stockdale Cynthia R CR Stanley Danielle D Jaffe Glenn G Balsley Brannon B Barbas Michael M Burns Russell R Busian Dee D Ebersohl Ryan R Heydary Cynthia C McEwan Sasha S Myers Justin J Robertson Amanda A Shields Kelly K Thompson Garrett G Winter Katrina K Young Ellen E Danis Ronald P RP Davis Matthew D MD Huang Yijun Y Blodi Barbara B Domalpally Amitha A Reimers James J Vargo Pamela P Wabers Hugh H Myers Dawn D Lawrence Daniel D Allan James J Jampol Lee M LM Bressler Neil M NM Antoszyk Andrew A Baker Carl W CW Sun Jennifer K JK Wells John A JA 3rd Friedman Scott S Bressler Susan B SB Scott Ingrid U IU Schron Eleanor E Everett Donald F DF Miskala Päivi H PH Connett John J Abrams Gary G Barnbaum Deborah R DR Flynn Harry H Weinstock Ruth S RS Wilkinson Charles P CP Wisniewski Stephen S Genuth Saul S Frank Robert R Aiello Lloyd Paul LP Antoszyk Andrew N AN Baker Carl W CW Beck Roy W RW Bressler Neil M NM Bressler Susan B SB Danis Ronald P RP Davis Matthew D MD Elman Michael J MJ Ferris Frederick L FL 3rd Glassman Adam R AR Gross Jeffrey G JG Jaffe Glenn J GJ Jampol Lee M LM Maturi Raj K RK Schron Eleanor E Sun Jennifer K JK Wells John A JA 3rd Bhavsar Abdhish A Brucker Alexander J AJ Chalam Kakarla V KV Everett Donald F DF Fish Joan J Friedman Scott S Googe Joseph J Jr. Holcomb Diana M DM Lauer Andreas A Marcus Dennis M DM McClain Ashley A Perez Brandi J BJ Scott Ingrid U IU Starr JoAnn J 2017 07 18 2017 11 28 2018 01 12 2018 3 12 6 0 2018 3 12 6 0 2018 3 12 6 0 aheadofprint 29525602 S0161-6420(17)32232-7 10.1016/j.ophtha.2018.01.019 29523772 2018 03 23

1470-8752 2018 Mar 09 Biochem. Soc. Trans. Glycosylation pathways at the ocular surface. BST20170408 10.1042/BST20170408 Glycosylation is a major form of enzymatic modification of organic molecules responsible for multiple biological processes in an organism. The biosynthesis of glycans is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying enzymes that collectively assemble and process monosaccharide moieties into a diverse array of structures. Many studies have provided insight into various pathways of glycosylation at the ocular surface, such as those related to the biosynthesis of mucin-typeO-glycans andN-glycans on proteins, but many others still remain largely unknown. This review provides an overview of the different classes of glycans described at the ocular surface focusing on their biosynthetic pathways and biological relevance. A precise understanding of these pathways under physiological and pathological conditions could help identify biomarkers and novel targets for therapeutic intervention. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. Rodriguez Benavente Maria C MC Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, U.S.A. Argüeso Pablo P Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, U.S.A. pablo_argueso@meei.harvard.edu. eng R01 EY024031 EY NEI NIH HHS United States R01 EY026147 EY NEI NIH HHS United States Journal Article Review 2018 03 09

England Biochem Soc Trans 7506897 0300-5127 biosynthetic pathways glycosylation ocular surface 2018 01 03 2018 01 23 2018 01 30 2018 3 11 6 0 2018 3 11 6 0 2018 3 11 6 0 aheadofprint 29523772 BST20170408 10.1042/BST20170408 29519880 2018 03 09

1468-2079 2018 Mar 08 Br J Ophthalmol Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. bjophthalmol-2017-310927 10.1136/bjophthalmol-2017-310927 To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects underwent an extensive dry eye examination, including evaluation of meibomian glands (MGs) by meibography, measurement of tear production and tear film osmolarity and grading of vital staining of the ocular surface. Moreover, slit-lamp biomicroscopy was undertaken, including grading of aniridia-associated keratopathy (AAK). Mean tear film osmolarity was significantly higher (314±11 mOsmol/L) in patients with aniridia compared with the healthy control group (303±11 mOsmol/L, p=0.002). Vital staining score was higher in the aniridia group (4.3±3.0) compared with healthy controls (2.4±1.6, p=0.02). The degree of staining correlated positively with the stage of AAK (r=0.44, p=0.008) and negatively with corneal sensitivity (r=-0.45, p=0.012). Number of expressible MGs was lower in aniridia subjects (2.9±1.6) than in controls (4.0±1.3, p=0.007). MG loss, staged from 0 to 3, was higher in the aniridia group than in the control group, both in upper eyelid (0.86±0.89 vs 0.10±0.31, p=0.001) and lower eyelid (0.94±0.73 vs 0.30±0.47, p=0.003). Computerised analyses showed thinning (p=0.004) and lower density (p<0.001) of the MGs compared with the healthy population. Patients with congenital aniridia demonstrate increased tear film osmolarity, ocular surface staining, loss of MGs and lower MG expressibility. We conclude that meibomian gland dysfunction and keratopathy are related to development of DED in aniridia. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Landsend Erlend Christoffer Sommer ECS http://orcid.org/0000-0002-9789-1932 Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. Faculty of Medicine, University of Oslo, Oslo, Norway. Pedersen Hilde Røgeberg HR http://orcid.org/0000-0003-3946-6687 National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University College of Southeast Norway, Kongsberg, Norway. Utheim Øygunn Aass ØA Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. Xiao Jiaxin J Faculty of Medicine, University of Oslo, Oslo, Norway. Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway. Adil Muhammed Yasin MY Faculty of Medicine, University of Oslo, Oslo, Norway. Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway. Tashbayev Behzod B Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway. Lagali Neil N Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. Dartt Darlene Ann DA Schepens Eye Research Institute/Massachusetts Eye and Ear/Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Baraas Rigmor C RC http://orcid.org/0000-0003-3259-7617 National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University College of Southeast Norway, Kongsberg, Norway. Utheim Tor Paaske TP Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. National Centre for Optics, Vision and Eye Care, Faculty of Health and Social Sciences, University College of Southeast Norway, Kongsberg, Norway. Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway. Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway. Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway. eng Journal Article 2018 03 08

England Br J Ophthalmol 0421041 0007-1161 cornea eye lids iris ocular surface tears Competing interests: None declared. 2017 06 26 2017 12 22 2018 02 24 2018 3 10 6 0 2018 3 10 6 0 2018 3 10 6 0 aheadofprint 29519880 bjophthalmol-2017-310927 10.1136/bjophthalmol-2017-310927 29517945 2018 03 08

1744-5078 2018 Mar 08 Ocul. Immunol. Inflamm. Management of Ocular Cicatricial Pemphigoid with Intravenous Immunoglobulin Monotherapy. 1-7 10.1080/09273948.2018.1433302 To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP). A chart review of all OCP patients seen at the Massachusetts Eye Research and Surgery Institution (MERSI) between 2005 and 2015 was completed. Stage was graded by using the Foster grading system. IVIg infusion was 2g/kg/cycle administered in 3 consecutive days monthly. Of 512 OCP patients, 17 patients (34 eyes) treated with IVIg monotherapy were identified. Seven were female and ten were male. The average age at diagnosis was 60.7-year-old. The follow up time ranged from 12 to 140 months. Twenty-six eyes (76.5%) achieved remission. Nine remission eyes received cataract surgeries, and 2 of them had relapse (22.2%). The other 17 eyes did not undergo ocular surgery and remained in remission. IVIg monotherapy showed high efficacy in stage 1 OCP (7/7, 100%). Ocular surgery can be associated with OCP relapse (Table 2). IVIg monotherapy is an effective and safe therapy in patients with recalcitrant OCP. Ocular surgery can be associated with OCP relapse. Ma Lina L a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. You Caiyun C a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. c Department of Ophthalmology , Tianjin Medical University General Hospital , Tianjin , China. Hernandez Mikhail M a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Maleki Arash A a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Lasave Andres A a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Schmidt Alexander A a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Stephenson Andrew A a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Zhao Thongzen T a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Anesi Stephen S a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. Foster C Stephen CS a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA. b Ocular Immunology and Uveitis Foundation , Waltham , Massachusetts , USA. d Department of Ophthalmology , Harvard Medical School , Boston , Massachusetts , USA. eng Journal Article 2018 03 08

England Ocul Immunol Inflamm 9312169 0927-3948 Intravenous Immunoglobulin monotherapy Ocular Cicatricial Pemphigoid relapsing 2018 3 9 6 0 2018 3 9 6 0 2018 3 9 6 0 aheadofprint 29517945 10.1080/09273948.2018.1433302 29517401 2018 03 08

1744-5108 2018 Mar 08 Orbit Revision eDCR using a superior pedicled mucosal flap. 1-6 10.1080/01676830.2018.1444062 Endoscopic dacryocystorhinostomies (eDCRs) show patency rates between 81% and 94%. However, dacryocystorhinostomy (DCR) failure and the need for revision remain a significant challenge. One of the principal challenges in revision eDCR is the need to surgically identify the correct osteotomy site and maintain long-term patency in the setting of previously instrumented and potentially scarred tissue. At the same time, the surgeon must assume that the blood supply to the commonly described anterior and posteriorly pedicled flaps has been compromised. The objective of the study is to describe a novel flap technique for revision eDCR. The superior based mucosal flap is a novel technique that provides a vascularized mucosa preserving technique in revision eDCR despite previous instrumentation of the lacrimal system. This technique provides wide exposure of the revision osteotomy site while simultaneously allowing a viable mucosal flap to be replaced at the conclusion of the procedure, thereby minimizing bone exposure and cicatricial restenosis. The authors have utilized this technique in 13 procedures with 100% positive identification of the lacrimal sac, a 0% complication rate, and a 100% success rate after a mean follow-up of 26.93 ± 10.33 months (range 6-35 months). The eDCR using the superior pedicled mucosal flap provides excellent exposure of the maxillary bone and the lacrimal sac. This method preserves vascularity of the flap using a superiorly based pedicle which is typically inviolate during both open and endoscopic primary DCR. The mucosal flap can then be replaced, thereby minimizing bone exposure and optimizing patency. Mueller Sarina K SK a Department of Otolaryngology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA. b Department of Otolaryngology , University of Erlangen-Nuremberg , Erlangen , Germany. Freitag Suzanne K SK c Department of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA. Lefebvre Daniel R DR c Department of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA. Lee Nahyoung G NG c Department of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA. Bleier Benjamin S BS a Department of Otolaryngology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA. eng Journal Article 2018 03 08

England Orbit 8301221 0167-6830 Endoscopy granulation tissue nasolacrimal duct obstruction pedicled flap tears 2018 3 9 6 0 2018 3 9 6 0 2018 3 9 6 0 aheadofprint 29517401 10.1080/01676830.2018.1444062 29505774 2018 03 05

1879-1891 2018 Mar 02 Am. J. Ophthalmol. Subtarsal Fibrosis is Associated with Ocular Surface Epitheliopathy in Graft-Versus-Host Disease. S0002-9394(18)30095-3 10.1016/j.ajo.2018.02.020 To evaluate occurrence of subtarsal fibrosis in patients with graft-versus-host disease (GVHD) and to determine its association with ocular surface epitheliopathy. Cross-sectional study. We enrolled 40 patients with moderate or severe dry eye disease including 20 patients with chronic ocular GVHD and 20 patients without (as the control group). All patients had a comprehensive ophthalmic assessment including evaluation for subtarsal fibrosis, corneal and conjunctival staining, tear break-up time (TBUT), and Schirmer test. Furthermore, meibomian gland drop-out area and densities of epithelial and stromal immune cells were measured using meibography and in vivo confocal microscopy, respectively. Subtarsal fibrosis was not seen in any eye of the non-GVHD group. However, 16 eyes (40%) of 10 patients (50%) in the GVHD group had subtarsal fibrosis (P<0.001) with an average involvement of 28.9±13.7% of the tarsal area. Fibrosis was more frequent in the upper lids (35%) than in the lower lids (5%). Regression analyses showed that corneal fluorescein staining was significantly associated with the extent of fibrosis (P<0.001, β=0.14) and TBUT (P<0.001, β= -0.53) but not with other clinical or imaging parameters. Conjunctival lissamine green staining also had a statistically significant association with the extent of fibrosis (P=0.04, β=0.12) but not other clinical or imaging parameters. Eyes with subtarsal fibrosis had a more severe ocular surface epitheliopathy compared with eyes without fibrosis. Subtarsal fibrosis is present in a significant percentage of patients with chronic ocular GVHD, likely contributing to the ocular surface damage in these patients. Copyright © 2018. Published by Elsevier Inc. Kheirkhah Ahmad A Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Coco Giulia G Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Satitpitakul Vannarut V Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial hospital, Thai Red Cross Society, Bangkok, Thailand. Dana Reza R Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: Reza_Dana@meei.harvard.edu. eng Journal Article 2018 03 02

United States Am J Ophthalmol 0370500 0002-9394 2017 07 18 2017 11 24 2018 02 23 2018 3 6 6 0 2018 3 6 6 0 2018 3 6 6 0 aheadofprint 29505774 S0002-9394(18)30095-3 10.1016/j.ajo.2018.02.020 29461408 2018 03 21

1538-9235 95 3 2018 Mar Optom Vis Sci Brimonidine Ophthalmic Solution 0.025% for Reduction of Ocular Redness: A Randomized Clinical Trial. 264-271 10.1097/OPX.0000000000001182 The α2-adrenergic receptor agonist brimonidine has been reported to induce conjunctival blanching in cataract, strabismus, laser refractive, and filtration procedures. Clinicians are often faced with red eyes with no apparent underlying pathology. Low-dose brimonidine reduced ocular redness in such subjects with efficacy maintained over 1 month and negligible rebound redness. The aim of this study was to evaluate the safety and efficacy of brimonidine tartrate ophthalmic solution 0.025% for the treatment of ocular redness. In this single-center, double-masked, phase 3 clinical trial, adult subjects with baseline redness of more than 1 unit in both eyes (0- to 4-unit scale) were randomized 2:1 to brimonidine 0.025% or vehicle. A single dose was administered in-office (day 1); thereafter subjects instilled treatment four times a day for 4 weeks, with clinic visits on days 15, 29, and 36 (7 days post-treatment). Efficacy end points included investigator-evaluated redness 5 to 240 minutes post-instillation on day 1 (primary); investigator-evaluated change from baseline 1, 360, and 480 minutes post-instillation on day 1, and 1 and 5 minutes post-instillation on days 15 and 29; total clearance of redness, and subject-assessed redness. Safety/tolerability measures included adverse events, rebound redness, and drop comfort. Sixty subjects were randomized (n = 40 brimonidine, n = 20 vehicle). Investigator-assessed redness was lower with brimonidine versus vehicle over the 5- to 240-minute post-instillation period (mean [SE], 0.62 [0.076] vs. 1.49 [0.108]; P < .0001) and at each time point within that period (P < .0001). At 1, 360, and 480 minutes post-instillation, respectively, the mean differences (95% confidence interval) between treatments were -0.73 (-1.05 to -0.41), -0.57 (-0.84 to -0.29), and -0.39 (-0.67 to -0.10), respectively. No tachyphylaxis was evident with brimonidine on days 15 and 29, and minimal rebound redness was observed following discontinuation. Adverse events were infrequent, and brimonidine was rated as very comfortable. Brimonidine 0.025% appeared safe and effective for reduction of ocular redness, with an 8-hour duration of action, no evidence of tachyphylaxis, and negligible rebound redness. McLaurin Eugene E Total Eye Care, PA, Memphis, Tennessee. Cavet Megan E ME Bausch + Lomb, Rochester, New York. Gomes Paul J PJ Ciolino Joseph B JB Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts *pgomes@oraclinical.com. eng Journal Article

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1537-6605 102 3 2018 Mar 01 Am. J. Hum. Genet. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 375-400 S0002-9297(18)30017-X 10.1016/j.ajhg.2018.01.015 Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10^-8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 × 10^-8). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2). Copyright © 2018 American Society of Human Genetics. All rights reserved. Sung Yun J YJ Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yunju@wustl.edu. Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg 93051, Germany. de Las Fuentes Lisa L Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USA. Bentley Amy R AR Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Brown Michael R MR Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA. Kraja Aldi T AT Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Schwander Karen K Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Ntalla Ioanna I William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK. Guo Xiuqing X Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Franceschini Nora N Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA. Lu Yingchang Y Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA. Cheng Ching-Yu CY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore. Sim Xueling X Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore. Vojinovic Dina D Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Marten Jonathan J Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Musani Solomon K SK Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA. Li Changwei C Department of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA. Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Kilpeläinen Tuomas O TO Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Richard Melissa A MA Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Noordam Raymond R Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands. Aslibekyan Stella S Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Aschard Hugues H Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Centre de Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France. Bartz Traci M TM Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA. Dorajoo Rajkumar R Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore. Liu Yongmei Y Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Manning Alisa K AK Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Rankinen Tuomo T Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Smith Albert Vernon AV Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland. Tajuddin Salman M SM Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Tayo Bamidele O BO Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA. Warren Helen R HR William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Zhao Wei W School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. Zhou Yanhua Y Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. Matoba Nana N Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan. Sofer Tamar T Department of Biostatistics, University of Washington, Seattle, WA 98105, USA. Alver Maris M Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. Amini Marzyeh M Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Boissel Mathilde M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France. Chai Jin Fang JF Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore. Chen Xu X Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden. Divers Jasmin J Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Gandin Ilaria I Department of Medical Sciences, University of Trieste, Trieste 34137, Italy. Gao Chuan C Department of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Giulianini Franco F Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Goel Anuj A Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Harris Sarah E SE Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK. Hartwig Fernando Pires FP Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil. Horimoto Andrea R V R ARVR Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil. Hsu Fang-Chi FC Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Kähönen Mika M Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. Kasturiratne Anuradhani A Department of Public Health, University of Kelaniya, Ragama, Sri Lanka. Kühnel Brigitte B Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany. Leander Karin K Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden. Lee Wen-Jane WJ Department of Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung 40705, Taiwan. Lin Keng-Hung KH Department of Opthalmology, Taichung Veterans General Hospital, Taichung 40705, Taiwan. 'an Luan Jian J MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. McKenzie Colin A CA Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica. Meian He H Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Nelson Christopher P CP Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. Rauramaa Rainer R Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland. Schupf Nicole N Taub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA. Scott Robert A RA MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Sheu Wayne H H WHH Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Institute of Medical Technology, National Chung-Hsing University, Taichung 40705, Taiwan. Stančáková Alena A Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70210, Finland. Takeuchi Fumihiko F Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan. van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Varga Tibor V TV Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden. Wang Heming H Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. Wang Yajuan Y Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. Ware Erin B EB School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Institute for Social Research, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48104, USA. Weiss Stefan S Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany. Wen Wanqing W Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Yanek Lisa R LR General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Zhang Weihua W Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK. Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Afaq Saima S Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK. Alfred Tamuno T Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA. Amin Najaf N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Arking Dan D McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Aung Tin T Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore. Barr R Graham RG Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA. Bielak Lawrence F LF School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. Boerwinkle Eric E Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA; Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA. Bottinger Erwin P EP Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA. Braund Peter S PS Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. Brody Jennifer A JA Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA. Broeckel Ulrich U Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Cabrera Claudia P CP William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Cade Brian B Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA. Caizheng Yu Y Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Campbell Archie A Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Canouil Mickaël M CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France. Chakravarti Aravinda A Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. CHARGE Neurology Working Group Chauhan Ganesh G Centre for Brain Research, Indian Institute of Schience, Bangalore 560012, India. Christensen Kaare K The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark. Cocca Massimiliano M Department of Medical Sciences, University of Trieste, Trieste 34137, Italy. COGENT-Kidney Consortium Collins Francis S FS Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Connell John M JM Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK. de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands. de Silva H Janaka HJ Department of Medicine, University of Kelaniya, Ragama, Sri Lanka. Debette Stephanie S Inserm U1219 Neuroepidemiology, University of Bordeaux, Bordeaux, France; Department of Neurology, University Hospital, Bordeaux, France; Boston University School of Medicine, Boston, MA 02118, USA. Dörr Marcus M DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Department of Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany. Duan Qing Q Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA. Eaton Charles B CB Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI 02860, USA. Ehret Georg G Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva 1211, Switzerland. Evangelou Evangelos E Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece. Faul Jessica D JD Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA. Fisher Virginia A VA Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. Forouhi Nita G NG MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Franco Oscar H OH Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Friedlander Yechiel Y Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel. Gao He H Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK. GIANT Consortium Gigante Bruna B Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden. Graff Misa M Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA. Gu C Charles CC Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Gu Dongfeng D Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Gupta Preeti P Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore. Hagenaars Saskia P SP Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK. Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA. He Jiang J Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA. Heikkinen Sami S University of Eastern Finland, Institute of Biomedicine, Kuopio 70211, Finland. Heng Chew-Kiat CK Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119228, Singapore. Hirata Makoto M Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, Japan. Hofman Albert A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Howard Barbara V BV MedStar Health Research Institute, Hyattsville, MD 20782, USA; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC 20057, USA. Hunt Steven S Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA; Weill Cornell Medicine in Qatar, Doha, Qatar. Irvin Marguerite R MR Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Jia Yucheng Y Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Joehanes Roby R Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA. Justice Anne E AE Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA. Katsuya Tomohiro T Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan. Kaufman Joel J Epidemiology, Department of Occupational and Environmental Medicine Program, University of Washington, Seattle, WA 98105, USA. Kerrison Nicola D ND MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Khor Chiea Chuen CC Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore. Koh Woon-Puay WP Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore. Koistinen Heikki A HA Department of Health, National Institute for Health and Welfare, Helsinki 00271, Finland; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland. Komulainen Pirjo P Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland. Kooperberg Charles C Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA. Krieger Jose E JE Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil. Kubo Michiaki M Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan. Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland. Langefeld Carl D CD Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA. Lehne Benjamin B Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK. Lewis Cora E CE Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA. Li Yize Y Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Lifelines Cohort Study Lifelines cohort study, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Lim Sing Hui SH Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore. Lin Shiow S Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA. Liu Jianjun J Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore. Liu Jingmin J WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA. Liu Kiang K Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Liu Yeheng Y Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Loh Marie M Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research 138648, Singapore. Lohman Kurt K KK Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Long Jirong J Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Louie Tin T Department of Biostatistics, University of Washington, Seattle, WA 98105, USA. Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. Mahajan Anubha A Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Meitinger Thomas T Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Human Genetics, Technische Universität München, Munich 80333, Germany. Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. Milani Lili L Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. Momozawa Yukihide Y Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan. Morris Andrew P AP Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK. Mosley Thomas H TH Jr. Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Munson Peter P Mathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USA. Murray Alison D AD The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK. Nalls Mike A MA Data Tecnica International, Glen Echo, MD 20812, USA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA. Nasri Ubaydah U Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Norris Jill M JM Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA. North Kari K Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA. Ogunniyi Adesola A Department of Medicine, University of Ibadan, Ibadan, Nigeria. Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK. Palmas Walter R WR Internal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA. Palmer Nicholette D ND Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Pankow James S JS Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA. Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden. Peters Annette A Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg 85764, Germany. Peyser Patricia A PA School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. Polasek Ozren O Faculty of Medicine, University of Split, Split, Croatia. Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland. Renström Frida F Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Department of Biobank Research, Umeå University, Umeå, Västerbotten 901 87, Sweden. Rice Treva K TK Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Ridker Paul M PM Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Robino Antonietta A Medical Genetics, IRCCS Burlo, Garofolo 34137, Italy. Robinson Jennifer G JG Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA. Rose Lynda M LM Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Rudan Igor I Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK. Sabanayagam Charumathi C Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore. Salako Babatunde L BL Department of Medicine, University of Ibadan, Ibadan, Nigeria. Sandow Kevin K Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Schmidt Carsten O CO DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany. Schreiner Pamela J PJ Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA. Scott William R WR Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK. Seshadri Sudha S Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA. Sever Peter P International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK. Sitlani Colleen M CM Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA. Smith Jennifer A JA School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Starr John M JM Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh EH8 9JZ, UK. Strauch Konstantin K Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich 81377, Germany. Tang Hua H Department of Genetics, Stanford University, Stanford, CA 94305, USA. Taylor Kent D KD Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Teo Yik Ying YY Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Life Sciences Institute, National University of Singapore, Singapore, Singapore 117456, Singapore; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore. Tham Yih Chung YC Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore. Uitterlinden André G AG Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. Waldenberger Melanie M Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany. Wang Lihua L Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Wang Ya X YX Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, China. Wei Wen Bin WB Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Williams Christine C Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Wilson Gregory G Jackson Heart Study, Department of Public Health, Jackson State University, Jackson, MS 39213, USA. Wojczynski Mary K MK Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. Yao Jie J Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Yuan Jian-Min JM Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. Zonderman Alan B AB Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Becker Diane M DM General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Bowden Donald W DW Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Chambers John C JC Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK. Chen Yii-Der Ida YI Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. de Faire Ulf U Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden. Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK. Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu 51010, Estonia; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA 02142, USA. Farrall Martin M Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Forrester Terrence T Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica. Franks Paul W PW Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Harvard T.H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA 02115, USA; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten 901 85, Sweden. Freedman Barry I BI Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Froguel Philippe P CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France; Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK. Gasparini Paolo P Department of Medical Sciences, University of Trieste, Trieste 34137, Italy; Division Experimental Genetics, Sidra, Doha 26999, Qatar. Gieger Christian C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany. Horta Bernardo Lessa BL Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil. Hung Yi-Jen YJ Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei 11490, Taiwan. Jonas Jost B JB Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim 68167, Germany. Kato Norihiro N Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan. Kooner Jaspal S JS Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK. Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland. Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Lifes Sciences, University of Tampere, Tampere 33014, Finland. Liang Kae-Woei KW School of Medicine, National Yang-ming University, Taipei, Taiwan; Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan; Department of Medicine, China Medical University, Taichung 40705, Taiwan. Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden. Newman Anne B AB Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. Oldehinkel Albertine J AJ Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Pereira Alexandre C AC Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil; Genetics, Harvard Medical School, Boston, MA 02115, USA. Redline Susan S Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA. Rettig Rainer R DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute of Physiology, University Medicine Greifswald, Greifswald 17495, Germany. Samani Nilesh J NJ Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. Scott James J National Heart and Lung Institute, Imperial College London, London W12 0NN, UK. Shu Xiao-Ou XO Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. van der Harst Pim P Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Wagenknecht Lynne E LE Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK. Watkins Hugh H Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Weir David R DR Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA. Wickremasinghe Ananda R AR Department of Public Health, University of Kelaniya, Ragama, Sri Lanka. Wu Tangchun T Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China. Zheng Wei W Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Kamatani Yoichiro Y Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan. Laurie Cathy C CC Department of Biostatistics, University of Washington, Seattle, WA 98105, USA. Bouchard Claude C Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. Cooper Richard S RS Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA. Evans Michele K MK Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Gudnason Vilmundur V Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland. Kardia Sharon L R SLR School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA. Kritchevsky Stephen B SB Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Levy Daniel D Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. O'Connell Jeff R JR Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Psaty Bruce M BM Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington, Health Research Institute, Seattle, WA 98101, USA. van Dam Rob M RM Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. Sims Mario M Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA. Arnett Donna K DK Dean's Office, University of Kentucky College of Public Health, Lexington, KY 40536, USA. Mook-Kanamori Dennis O DO Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden 2300RC, the Netherlands. Kelly Tanika N TN Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA. Fox Ervin R ER Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA. Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. Fornage Myriam M Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Rotimi Charles N CN Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. Province Michael A MA Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA. van Duijn Cornelia M CM Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. Tai E Shyong ES Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. Wong Tien Yin TY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore. Loos Ruth J F RJF Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA; Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, NY 10029, USA. Reiner Alex P AP Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA. Rotter Jerome I JI Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Genomic Outcomes, Department of Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Zhu Xiaofeng X Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. Bierut Laura J LJ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. Gauderman W James WJ Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA. Caulfield Mark J MJ William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Elliott Paul P Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK. Rice Kenneth K Department of Biostatistics, University of Washington, Seattle, WA 98105, USA. Munroe Patricia B PB William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK. Morrison Alanna C AC Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA. Cupples L Adrienne LA Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA. Rao Dabeeru C DC Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Chasman Daniel I DI Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: dchasman@research.bwh.harvard.edu. eng R01 HL105756 HL NHLBI NIH HHS United States R01 MD012765 MD NIMHD NIH HHS United States R21 HL123677 HL NHLBI NIH HHS United States U01 AG009740 AG NIA NIH HHS United States Journal Article 2018 02 15

United States Am J Hum Genet 0370475 0002-9297 GWAS GxE interactions blood pressure lifestyle multi-ancestry smoking 2017 10 10 2018 01 18 2018 2 20 6 0 2018 2 20 6 0 2018 2 20 6 0 ppublish 29455858 S0002-9297(18)30017-X 10.1016/j.ajhg.2018.01.015 29423508 2018 03 30

2168-6173 136 3 2018 Mar 01 JAMA Ophthalmol Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid: A Secondary Analysis of a Randomized Clinical Trial. 271-277 10.1001/jamaophthalmol.2017.6658 Mice with oxygen-induced retinopathy fed matched diets except for ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) vs ω-6 LC-PUFAs demonstrate relative antiangiogenic and neuroprotective associations of ω-3 LC-PUFAs. However, supplementing preterm infants with LC-PUFAs has been inconsistent in reducing major preterm morbidities. However, few studies measured serum lipid levels after supplementation. To examine the associated risk of retinopathy of prematurity (ROP) from the levels of circulating ω-3 and ω-6 LC-PUFAs. This longitudinal clinical study was a further analysis of serum lipid levels from a randomized controlled trial cohort of 90 infants born at gestational age (GA) less than 28 weeks. From April 4, 2013, to September 22, 2015, cord blood samples, followed by venous blood samples, were obtained at birth and at 1, 7, 14, and 28 days after birth and then at postmenstrual age (PMA) 32, 36, and 40 weeks at the neonatal intensive care unit at Sahlgrenska University Hospital in Göteborg, Sweden. Serum phospholipid fatty acids were transmethylated and measured by gas chromatography-mass spectrometry. Mann-Whitney test, logistic regression Spearman rank correlation, and receiver operating characteristic curve analysis were used to compare differences between infants with no ROP and infants who developed ROP. Serum levels from 78 infants (43 male [55%]; mean [SD] GA, 25.5 [1.4] weeks) with a known ROP outcome were evaluated. Lower area under the curve (AUC) of arachidonic acid (AA) (20:4 ω-6) was seen in infants with a later diagnosis of ROP compared with infants with no ROP in the first month of life (mean, 34.05 [95% CI, 32.10-36.00] vs 37.15 [95% CI, 34.85-39.46]; P < .05). In addition, lower levels of AA at 32 weeks' PMA were seen in infants with later severe ROP compared with in those without ROP (mean, 7.06 [95% CI, 6.60-7.52] vs 8.74 [95% CI, 7.80-9.67]; P < .001). In logistic modeling, low postnatal serum levels of AA and GA at birth identified with a sensitivity greater than 90% of infants who developed ROP. Low postnatal levels of the ω-6 LC-PUFAs (AA) are strongly associated with ROP development. Evaluating postnatal AA fraction after birth in addition to GA may be useful for ROP prediction. clinicaltrials.gov Identifier: NCT02760472. Löfqvist Chatarina A CA Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Najm Svetlana S Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Hellgren Gunnel G Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Engström Eva E Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Sävman Karin K Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Nilsson Anders K AK Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Andersson Mats X MX Department of Biology and Environmental Sciences, University of Gothenburg, Göteborg, Sweden. Hård Anna-Lena AL Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. Smith Lois E H LEH Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Hellström Ann A Section of Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. eng ClinicalTrials.gov NCT02760472 R01 EY017017 EY NEI NIH HHS United States Journal Article

United States JAMA Ophthalmol 101589539 2168-6165 2018 2 10 6 0 2018 2 10 6 0 2018 2 10 6 0 ppublish 29423508 2671942 10.1001/jamaophthalmol.2017.6658 29380459 2018 03 03

1460-9568 47 5 2018 Mar Eur. J. Neurosci. Early blindness is associated with increased volume of the uncinate fasciculus. 427-432 10.1111/ejn.13848 Growing evidence demonstrates dramatic structural and functional neuroplastic changes in individuals born with early-onset blindness. For example, cross-modal sensory processing at the level of the occipital cortex appears to be associated with adaptive behaviors in the blind. However, detailed studies examining the structural properties of key white matter pathways in other regions of the brain remain limited. Given that blind individuals rely heavily on their sense of hearing, we examined the structural properties of two important pathways involved with auditory processing, namely the uncinate and arcuate fasciculi. High angular resolution diffusion imaging (HARDI) tractography was used to examine structural parameters (i.e., tract volume and quantitative anisotropy, or QA) of these two fasciculi in a sample of 13 early blind individuals and 14 normally sighted controls. Compared to controls, early blind individuals showed a significant increase in the volume of the left uncinate fasciculus. A small area of increased QA was also observed halfway along the right arcuate fasciculus in the blind group. These findings contribute to our knowledge regarding the broad neuroplastic changes associated with profound early blindness. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. Bauer Corinna M CM http://orcid.org/0000-0001-9407-4657 Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA. Cattaneo Zaira Z http://orcid.org/0000-0001-7516-7508 Department of Psychology, University of Milano-Biococca, Milan, Italy. Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy. Merabet Lotfi B LB Laboratory for Visual Neuroplasticity, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 20 Staniford Street, Boston, MA, 02114, USA. eng Journal Article 2018 02 16

France Eur J Neurosci 8918110 0953-816X HARDI tractography arcuate fasciculus early blindness uncinate fasciculus 2017 06 05 2018 01 08 2018 01 15 2018 1 31 6 0 2018 1 31 6 0 2018 1 31 6 0 ppublish 29380459 10.1111/ejn.13848 29346472 2018 03 09

2168-6173 136 3 2018 Mar 01 JAMA Ophthalmol A Revised Estimate of Costs Associated With Routine Preoperative Testing in Medicare Cataract Patients With a Procedure-Specific Indicator. 231-238 10.1001/jamaophthalmol.2017.6372 Routine preoperative medical testing is not recommended for patients undergoing low-risk surgery, but testing is common before surgery. A 30-day preoperative testing window is conventionally used for study purposes; however, the extent of routine testing that occurs prior to that point is unknown. To improve on existing cost estimates by identifying all routine preoperative testing that takes place after the decision is made to perform cataract surgery. This cross-sectional study assessed preoperative care in a 50% sample of Medicare beneficiaries older than 66 years who underwent ambulatory cataract surgery in 2011. Data analysis was completed from March 2016 to October 2017. Using ocular biometry as a procedure-specific indicator to mark the start of the routine preoperative testing window, we measured testing rates in the interval between ocular biometry and cataract surgery and compared this with testing rates in the 6 months preceding biometry. We estimated the total cost of testing that occurred between biometry and cataract surgery. A total of 440 857 patients underwent cataract surgery. A total of 423 710 (96.1%) had an ocular biometry claim before index surgery, of whom 264 514 (60.0%) were female; the mean (SD) age of the cohort was 76.1 (6.2) years. A total of 111 998 (25.4%) underwent surgery more than 30 days after biometry. Among patients with a biometry claim, the mean number of tests/patient/month increased from 1.1 in the baseline period to 1.7 in the interval between biometry and cataract surgery. Although preoperative testing peaked in all patients in the 30 days preceding surgery (1.8 tests/patient/month), the subset of patients with no overlap between postbiometry and presurgery periods experienced increased testing rates to 1.8 tests per patient per month in the 30 days after biometry, regardless of the elapsed time between biometry and surgery. The total estimated cost of routine preoperative testing in the full cohort was $22.7 million; we estimate that routine preoperative testing costs Medicare up to $45.4 million annually. In this study of Medicare beneficiaries, routine preoperative medical testing occurs more often and is costlier than has been reported previously. Extra costs are attributable to testing that occurs prior to the 30-day window preceding surgery. As a cost-cutting measure, routine preoperative medical testing should be avoided in patients with cataracts throughout the interval between ocular biometry and cataract surgery. Chen Catherine L CL Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California, San Francisco. Center for Healthcare Value, University of California, San Francisco. Department of Anesthesiology and Perioperative Care, University of California, San Francisco. Clay Theodore H TH Clay Software and Statistics, Ashland, Oregon. McLeod Stephen S Department of Ophthalmology, University of California, San Francisco. Chang Han-Ying Peggy HP Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston. Gelb Adrian W AW Department of Anesthesiology and Perioperative Care, University of California, San Francisco. Dudley R Adams RA Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California, San Francisco. Center for Healthcare Value, University of California, San Francisco. Department of Medicine, University of California, San Francisco. eng Journal Article

United States JAMA Ophthalmol 101589539 2168-6165 2018 1 19 6 0 2018 1 19 6 0 2018 1 19 6 0 ppublish 29346472 2668284 10.1001/jamaophthalmol.2017.6372 29343568 2018 03 15

1098-5514 92 7 2018 Apr 01 J. Virol. An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor. e02213-17 10.1128/JVI.02213-17 Determinants and mechanisms of cell attachment and entry steer adeno-associated virus (AAV) in its utility as a gene therapy vector. Thus far, a systematic assessment of how diverse AAV serotypes engage their proteinaceous receptor AAVR (KIAA0319L) to establish transduction has been lacking, despite potential implications for cell and tissue tropism. Here, a large set of human and simian AAVs as well asin silico-reconstructed ancestral AAV capsids were interrogated for AAVR usage. We identified a distinct AAV capsid lineage comprised of AAV4 and AAVrh32.33 that can bind and transduce cells in the absence of AAVR, independent of the multiplicity of infection. Virus overlay assays and rescue experiments in nonpermissive cells demonstrate that these AAVs are unable to bind to or use the AAVR protein for entry. Further evidence for a distinct entry pathway was observedin vivo, as AAVR knockout mice were equally as permissive to transduction by AAVrh32.33 as wild-type mice upon systemic injection. We interestingly observe that some AAV capsids undergo a low level of transduction in the absence of AAVR, bothin vitroandin vivo, suggesting that some capsids may have a multimodal entry pathway. In aggregate, our results demonstrate that AAVR usage is conserved among all primate AAVs except for those of the AAV4 lineage, and a non-AAVR pathway may be available to other serotypes. This work furthers our understanding of the entry of AAV, a vector system of broad utility in gene therapy.IMPORTANCEAdeno-associated virus (AAV) is a nonpathogenic virus that is used as a vehicle for gene delivery. Here, we have identified several situations in which transduction is retained in both cell lines and a mouse model in the absence of a previously defined entry receptor, AAVR. Defining the molecular determinants of the infectious pathway of this highly relevant viral vector system can help refine future applications and therapies with this vector. Copyright © 2018 American Society for Microbiology. Dudek Amanda M AM Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. Harvard Ph.D. Program in Virology, Division of Medical Sciences, Harvard University, Boston, Massachusetts, USA. Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Pillay Sirika S Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Puschnik Andreas S AS Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Nagamine Claude M CM Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California, USA. Cheng Fang F Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA. Qiu Jianming J Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA. Carette Jan E JE Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Vandenberghe Luk H LH https://orcid.org/0000-0002-3508-4924 Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA Luk_Vandenberghe@MEEI.harvard.edu. Harvard Ph.D. Program in Virology, Division of Medical Sciences, Harvard University, Boston, Massachusetts, USA. Ocular Genomics Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. eng Journal Article 2018 03 14

United States J Virol 0113724 0022-538X AAV adeno-associated virus attachment gene therapy vector viral entry viral gene transfer virus virus receptor 2018 01 02 2018 01 03 2018 1 19 6 0 2018 1 19 6 0 2018 1 19 6 0 epublish 29343568 JVI.02213-17 10.1128/JVI.02213-17 29330062 2018 03 05

1879-1891 187 2018 Mar Am. J. Ophthalmol. Fundus Densitometry Findings Suggest Optic Disc Hemorrhages in Primary Open-Angle Glaucoma Have an Arterial Origin. 108-116 S0002-9394(18)30005-9 10.1016/j.ajo.2017.12.024 To analyze optic disc hemorrhages (DH) associated with primary open-angle glaucoma by quantifying their geometric profile and comparing their densitometry with hemorrhages from retinal vein occlusions (RVO) and retinal macroaneurysms (MA), which have venous and arterial sources of bleeding, respectively. Retrospective cross-sectional study. Setting: Massachusetts Eye & Ear. Fundus images of DH (n = 40), MA (n = 14), and RVO (n = 25) were identified. Patient clinical backgrounds and demographics were obtained. Grayscale pixel intensity units of hemorrhages and adjacent arteriole and venule over the same background tissue were measured. Densitometry differentials (arteriole or venule minus hemorrhage [ΔA and ΔV, respectively]) were calculated. The ratios of length (radial) to midpoint width for DH were calculated. Mean ΔA and ΔV between groups were compared with t tests. Multiple linear regression assessed the relation of retinal hemorrhage diagnosis to ΔA and ΔV and of DH shape to ΔA and ΔV. Mean (± standard deviation) ΔA and ΔV for DH (6.9 ± 7.1 and -4.7 ± 8.0 pixel intensity units, respectively) and MA (5.3 ± 5.9 and -6.0 ± 4.6, respectively) were comparable (P ≥ .43). Mean ΔA (14.6 ± 7.7) and ΔV (6.4 ± 6.3) for RVO were significantly higher compared to DH and MA (P < .0001) and remained significant in multivariable analyses. A unit increase in DH length-to-width ratio was associated with 1.2 (0.5) and 1.3 (0.5) pixel intensity unit (standard error) decrease in ΔA and ΔV, respectively (P ≤ .014). DH have densitometry profiles comparable to MA and different from RVO, suggesting that DH in glaucoma have an arterial origin. Copyright © 2018 Elsevier Inc. All rights reserved. Chou Jonathan C JC Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Cousins Clara C CC Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Miller John B JB Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Song Brian J BJ Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Shen Lucy Q LQ Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Kass Michael A MA Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri. Wiggs Janey L JL Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Pasquale Louis R LR Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: Louis_pasquale@meei.harvard.edu. eng Journal Article 2018 01 09

United States Am J Ophthalmol 0370500 0002-9394 2017 10 27 2017 12 11 2017 12 27 2018 1 14 6 0 2018 1 14 6 0 2018 1 14 6 0 ppublish 29330062 S0002-9394(18)30005-9 10.1016/j.ajo.2017.12.024 29309486 2018 03 09

2168-6211 172 3 2018 Mar 01 JAMA Pediatr Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical Trial. 278-286 10.1001/jamapediatrics.2017.4838 Anti-vascular endothelial growth factor (VEGF) therapies are a novel treatment option in retinopathy of prematurity (ROP). Data on dosing, efficacy, and safety are insufficient. To investigate lower doses of anti-VEGF therapy with ranibizumab, a substance with a significantly shorter systemic half-life than the standard treatment, bevacizumab. This randomized, multicenter, double-blind, investigator-initiated trial at 9 academic medical centers in Germany compared ranibizumab doses of 0.12 mg vs 0.20 mg in infants with bilateral aggressive posterior ROP; ROP stage 1 with plus disease, 2 with plus disease, or 3 with or without plus disease in zone I; or ROP stage 3 with plus disease in posterior zone II. Patients were recruited between September 2014 and August 2016. Twenty infants were screened and 19 were randomized. All infants received 1 baseline ranibizumab injection per eye. Reinjections were allowed in case of ROP recurrence after at least 28 days. The primary end point was the number of infants who did not require rescue therapy at 24 weeks. Key secondary end points included time-to-event analyses, progression of physiologic vascularization, and plasma VEGF levels. Stages of ROP were photodocumented and reviewed by an expert committee. Nineteen infants with ROP were enrolled (9 [47.4%] female; median [range] postmenstrual age at first treatment, 36.4 [34.7-39.7] weeks), 3 of whom died during the study (1 in the 0.12-mg group and 2 in the 0.20-mg group). Of the surviving infants, 8 (88.9%) (17 eyes [94.4%]) in the 0.12-mg group and 6 (85.7%) (13 eyes [92.9%]) in the 0.20-mg group did not require rescue therapy. Both ranibizumab doses were equally successful in controlling acute ROP (Cochran-Mantel-Haenszel analysis; odds ratio, 1.88; 95% CI, 0.26-13.49; P = .53). Physiologic intraretinal vascularization was superior in the 0.12-mg group. The VEGF plasma levels were not systematically altered in either group. This pilot study demonstrates that ranibizumab is effective in controlling acute ROP and that 24% of the standard adult dose (0.12 mg) appears equally effective as 40% (0.20 mg). Superior vascularization of the peripheral retina with 0.12 mg of ranibizumab indicates that the lower dose may be favorable. Unchanged plasma VEGF levels point toward a limited systemic drug exposure after ranibizumab. clinicaltrials.gov Identifier: NCT02134457 and clinicaltrialsregister.eu Identifier: 2013-002539-13. Stahl Andreas A Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Krohne Tim U TU Department of Ophthalmology, University of Bonn, Bonn, Germany. Eter Nicole N Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany. Oberacher-Velten Isabel I Department of Ophthalmology, University of Regensburg, Regensburg, Germany. Guthoff Rainer R Department of Ophthalmology, Faculty of Medicine, University of Dusseldorf, Dusseldorf, Germany. Meltendorf Synke S Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany. Ehrt Oliver O Department of Ophthalmology, Ludwig-Maximilian University of Munich, Munich, Germany. Aisenbrey Sabine S University Eye Hospital, Eberhard Karls University of Tuebingen, Tuebingen, Germany. Roider Johann J Department of Ophthalmology, University of Kiel, University Medical Center, Kiel, Germany. Gerding Heinrich H Augenzentrum Pallas Kliniken, Olten, Switzerland. Jandeck Claudia C Artemis Eye Clinic, Frankfurt, Germany. Smith Lois E H LEH Department of Ophthalmology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts. Walz Johanna M JM Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany. Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) Study Group eng ClinicalTrials.gov NCT02134457 R01 EY017017 EY NEI NIH HHS United States U54 HD090255 HD NICHD NIH HHS United States Journal Article

United States JAMA Pediatr 101589544 2168-6203 Br J Ophthalmol. 2014 Dec;98(12):1636-41 25001321 JAMA Ophthalmol. 2017 Jun 1;135(6):654-656 28448664 PLoS One. 2015 Jun 17;10(6):e0129383 26083024 Lancet. 2013 Oct 26;382(9902):1445-57 23782686 J AAPOS. 2012 Feb;16(1):2-4 22237669 Acta Ophthalmol. 2016 Dec;94(8):e744-e752 27197876 Arch Ophthalmol. 2005 Jul;123(7):991-9 16009843 Cancer Chemother Pharmacol. 2008 Oct;62(5):779-86 18205003 Ophthalmology. 2015 May;122(5):1008-15 25687024 Clin Perinatol. 2013 Jun;40(2):201-14 23719305 Curr Opin Pediatr. 2011 Apr;23(2):173-8 21150442 PLoS One. 2016 Jan 05;11(1):e0145375 26730574 Arch Dis Child Fetal Neonatal Ed. 2013 Mar;98(2):F170-4 22209748 Ophthalmic Surg Lasers Imaging Retina. 2015 Jul-Aug;46(7):752-4 26247131 Invest Ophthalmol Vis Sci. 2015 Jan 22;56(2):956-61 25613938 Invest Ophthalmol Vis Sci. 2013 Mar 05;54(3):1616-24 23361508 Retina. 2017 Apr;37(4):694-701 27467377 N Engl J Med. 2011 Feb 17;364(7):603-15 21323540 Clin Perinatol. 2014 Dec;41(4):925-43 25459781 Am J Ophthalmol. 2012 Feb;153(2):327-333.e1 21930258 J Clin Invest. 2010 Sep;120(9):3022-32 20811158 Acta Ophthalmol. 2013 Feb;91(1):e74-5 22672259 Arch Ophthalmol. 2012 Aug;130(8):1000-6 22491394 Invest Ophthalmol Vis Sci. 2011 Jun 08;52(7):4039-47 21357392 Ophthalmologe. 2014 Feb;111(2):113-20 24346958 Retina. 2017 Oct;37(10 ):1847-1858 28106709 Retina. 2015 Sep;35(9):1772-7 25829347 Retina. 2015 Apr;35(4):675-80 25768252 Sci Rep. 2016 Jun 01;6:27082 27256987 Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):280-3 26985803 2018 09 01 2018 1 9 6 0 2018 1 9 6 0 2018 1 9 6 0 ppublish 29309486 2667558 10.1001/jamapediatrics.2017.4838 PMC5840003 NIHMS935394 29303880 2018 02 28

1536-481X 27 3 2018 Mar J. Glaucoma Ab Interno Tube Occlusion for Postoperative Hypotony in a Patient With an Ahmed Glaucoma Drainage Device. e61-e63 10.1097/IJG.0000000000000869 To report a case of Ahmed glaucoma valve-induced hypotony that was successfully managed with postoperative intraluminal stenting of the aqueous shunt tube. We describe a 68-year-old man with advanced uveitic glaucoma with an intraocular pressure (IOP) of 25 mm Hg in the left eye. The patient initially responded well to an Ahmed glaucoma valve implant, but at 10 weeks postimplantation, the patient underwent cataract surgery and developed persistent hypotony, choroidal folds, and decreased vision. Before partial occlusion of the aqueous shunt tube, the patient had an IOP of 3 mm Hg and a best-corrected visual acuity (BCVA) of 20/60. Following intraluminal stenting of the aqueous shunt tube with 4-0 polypropylene suture (Prolene; Ethican), IOP rose from 7 to 10 mm Hg, BCVA improved to 20/30, and the choroidal folds resolved; IOP and BCVA remained stable through 1 year of follow-up and no additional surgical or pharmacological interventions were required. Aqueous shunt-induced hypotony can be successfully managed with intraluminal stenting and should be considered before tubal ligation or shunt removal. Feinstein Max M Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, CA. Moussa Kareem K Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Han Ying Y Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, CA. eng Journal Article

United States J Glaucoma 9300903 1057-0829 2018 1 6 6 0 2018 1 6 6 0 2018 1 6 6 0 ppublish 29303880 10.1097/IJG.0000000000000869 29303872 2018 02 28

1536-481X 27 3 2018 Mar J. Glaucoma The Association Between Body Mass Index and Open-angle Glaucoma in a South Korean Population-based Sample. 239-245 10.1097/IJG.0000000000000867 The purpose of this article is to investigate the association between body mass index (BMI) and open-angle glaucoma (OAG) in a sample of the South Korean population. The sample consisted of a cross-sectional, population-based sample of 10,978 participants, 40 years of age and older, enrolled in the 2008 to 2011 Korean National Health and Nutrition Examination Survey. All participants had measured intraocular pressure <22 mm Hg and open anterior chamber angles. OAG was defined using disc and visual field criteria established by the International Society for Geographical and Epidemiological Ophthalmology. Multivariable analyses were performed to determine the association between BMI and OAG. These analyses were also performed in a sex-stratified and age-stratified manner. After adjusting for potential confounding variables, lower BMI (<19 kg/m) was associated with greater risk of OAG compared with normal BMI (19 to 24.9 kg/m) [odds ratio (OR), 2.28; 95% confidence interval (CI), 1.22-4.26]. In sex-stratified analyses, low BMI remained adversely related to glaucoma in women (OR, 3.45; 95% CI, 1.42-8.38) but not in men (OR, 1.72; 95% CI, 0.71-4.20). In age-stratified analyses, lower BMI was adversely related to glaucoma among subjects 40- to 49-year old (OR, 5.16; 95% CI, 1.86-14.36) but differences in glaucoma prevalence were not statistically significant between those with low versus normal BMI in other age strata. Lower BMI was associated with increased odds of OAG in a sample of the South Korean population. Multivariate analysis revealed the association to be statistically significant in women and those in the youngest age stratum. Lin Shuai-Chun SC Department of Ophthalmology, University of California San Francisco, San Francisco. Department of Medicine, National Yang-Ming University, Taipei, Taiwan. Pasquale Louis R LR Massachusetts Eye and Ear Infirmary, Glaucoma Service. Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Singh Kuldev K Department of Ophthalmology, Stanford University, Stanford, CA. Lin Shan C SC Department of Ophthalmology, University of California San Francisco, San Francisco. eng Journal Article

United States J Glaucoma 9300903 1057-0829 2018 1 6 6 0 2018 1 6 6 0 2018 1 6 6 0 ppublish 29303872 10.1097/IJG.0000000000000867 29258731 2018 03 05

1879-1891 187 2018 Mar Am. J. Ophthalmol. Characteristics and Visual Outcome of Refractory Retinal Vasculitis Associated With Antineutrophil Cytoplasm Antibody-Associated Vasculitides. 21-33 S0002-9394(17)30532-9 10.1016/j.ajo.2017.12.004 To describe the clinical characteristics, therapies, visual outcomes, and prognoses of patients with retinal vasculitis associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). Retrospective case series. Patients diagnosed with retinal vasculitis associated with AAV and at least 6 months of follow-up were included. Demographic data, systemic and ocular features, best-corrected visual acuity at the initial visit and latest visit, fluorescein angiography (FA) and indocyanine green angiography (ICGA) findings, therapy regimen, and outcome were collected from the Massachusetts Eye Research and Surgery Institution (MERSI) database from 2006 to 2017. Fourteen patients (22 eyes) were identified. Twelve had granulomatosis with polyangiitis (GPA) and 1 each had microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). FA showed that AAV affected small-to-medium-size retinal vessels. Seven cases (50%) had both vein/venule and artery/arteriole involvement. Four cases co-presented with choroidal vasculitis. All of them failed various immunomodulatory therapies prior to referral to MERSI. Six patients received rituximab plus prednisone as their final therapy and 5 of them achieved remission. Four patients who failed cyclophosphamide previously were induced into remission by rituximab. Patients were followed for 33.4 ± 25.5 (range 6-84) months. Nine of 14 patients (64.3%) achieved remission at their latest visit. Seventeen of 22 eyes (77.3%) met the criteria for a good (≥20/40) visual outcome. The majority of patients enjoyed a good visual outcome and achieved remission after aggressive treatment. Rituximab should be considered as an initial treatment for patients with refractory retinal vasculitis associated with AAV. Copyright © 2017 Elsevier Inc. All rights reserved. Lin Miaoli M Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Anesi Stephen D SD Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts. Ma Lina L Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts. Ahmed Aseef A Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts. Small Karen K Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts. Foster C Stephen CS Massachusetts Eye Research and Surgery Institution, Waltham, Massachusetts; Ocular Immunology and Uveitis Foundation, Waltham, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address: sfoster@mersi.com. eng Journal Article 2017 12 16

United States Am J Ophthalmol 0370500 0002-9394 2017 09 27 2017 12 06 2017 12 08 2017 12 21 6 0 2017 12 21 6 0 2017 12 21 6 0 ppublish 29258731 S0002-9394(17)30532-9 10.1016/j.ajo.2017.12.004 29176450 2018 02 05

1536-4798 37 3 2018 Mar Cornea Corneal Cross-Linking With Verteporfin and Nonthermal Laser Therapy. 362-368 10.1097/ICO.0000000000001473 To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo. Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined treatment of verteporfin with nonthermal laser therapy for 1 sequence (V+NTL1) or 6 sequences (V+NTL6) of 1 minute of NTL exposure. Positive controls were pretreated with 0.1% riboflavin/20% dextran every 3 to 5 minutes for 30 minutes and irradiated with ultraviolet light type A (λ = 370 nm, irradiance = 3 mW/cm) for 30 minutes using the Dresden protocol (R+UVA). Untreated corneas were used as negative controls. The corneal biomechanical properties were measured with enzymatic digestion, compression, creep, and tensile strength testing. V+NTL6- and R+UVA-treated corneas acquired higher rigidity and more pronounced curvature than untreated corneas. The stress-strain tests showed that V+NTL6 and R+UVA corneas became significantly stiffer than controls (P < 0.005). The V+NTL6 group seemed to be slightly stiffer than the R+UVA group, although the differences were not statistically significant. V+NTL6 corneas were found to have a significantly lower absolute creep rate (-1.87 vs. -3.46, P < 0.05) and significantly higher maximum stress values (7.67 vs. 3.02 P < 0.05) compared with untreated corneas. Verteporfin-NTL (V+NTL6) increases corneal mechanical stiffness and resistance to enzymatic collagenase degradation. Although a clinical study is needed, our results suggest that V+NTL6 induces corneal cross-linking and corneal biomechanical changes that are similar to those induced by standard corneal collagen cross-linking. Alageel Saleh A SA Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. Arafat Samer N SN Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. Salvador-Culla Borja B Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. Kolovou Paraskevi E PE Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. Jahanseir Khadijeh K Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. Kozak Adam A Cambridge Polymer Group, Boston, MA. Braithwaite Gavin J C GJC Cambridge Polymer Group, Boston, MA. Ciolino Joseph B JB Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA. eng Journal Article

United States Cornea 8216186 0277-3740 2017 11 28 6 0 2017 11 28 6 0 2017 11 28 6 0 ppublish 29176450 10.1097/ICO.0000000000001473 28926503 2018 03 08

1537-2677 34 2 2018 Mar/Apr Ophthal Plast Reconstr Surg Acquired Intermittent Pediatric Horner Syndrome due to Neuroblastoma. e38-e41 10.1097/IOP.0000000000001001 A 3-month-old male developed intermittent left upper eyelid ptosis at the age of 1 month that was gradually increasing in frequency and duration. Examination revealed anisocoria and left upper and lower eyelid ptosis, consistent with a left Horner syndrome. Imaging showed a mass in the left superior posterior mediastinum, which was resected, and pathology was consistent with neuroblastoma. Eight months thereafter, the patient underwent left upper eyelid ptosis repair. Cases of infantile acquired Horner syndrome due to neuroblastoma are rare. To the authors' knowledge, there has only been one case described that presented with intermittent symptoms. The authors report the second case of intermittent acquired Horner syndrome due to neuroblastoma. This case demonstrates the importance of recognizing that Horner syndrome may present with subtle and intermittent symptoms. In a pediatric patient, one should maintain suspicion for neuroblastoma. Cohen Liza M LM Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Elliott Alexandra A Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. Freitag Suzanne K SK Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts. eng Journal Article

United States Ophthal Plast Reconstr Surg 8508431 0740-9303 2017 9 20 6 0 2017 9 20 6 0 2017 9 20 6 0 ppublish 28926503 10.1097/IOP.0000000000001001 29581352 2018 03 27

1468-2079 2018 Mar 26 Br J Ophthalmol Surgical adhesives in ophthalmology: history and current trends. bjophthalmol-2017-311643 10.1136/bjophthalmol-2017-311643 Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. The primary synthetic glues include cyanoacrylate and the recently introduced polyethylene glycol (PEG) derivatives, while most biological glues are composed of fibrin. Cyanoacrylate has a high tensile strength, but rapidly polymerises upon contact with any fluid and has been associated with histotoxicity. Fibrin induces less toxic and inflammatory reactions, and its polymerisation time can be controlled. Tensile strength studies have shown that fibrin is not as strong as cyanoacrylate. While more research is needed, PEG variants currently appear to have the most promise. These glues are non-toxic, strong and time-effective. Through MEDLINE and internet searches, this paper presents a systematic review of the current applications of surgical adhesives to corneal, glaucoma, retinal, cataract and strabismus surgeries. Our review suggests that surgical adhesives have promise to reduce problems in current ophthalmic surgical procedures. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Guhan Samantha S http://orcid.org/0000-0002-5095-9733 Harvard Medical School, Boston, Massachusetts, USA. Peng Si-Liang SL Boston Eye Group, Boston, Massachusetts, USA. Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Janbatian Hrag H Harvard Medical School, Boston, Massachusetts, USA. Boston Eye Group, Boston, Massachusetts, USA. Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Saadeh Stephanie S Boston Eye Group, Boston, Massachusetts, USA. Greenstein Stephen S Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Al Bahrani Faisal F Boston Eye Group, Boston, Massachusetts, USA. Boston University, Boston, Massachusetts, USA. Fadlallah Ali A Harvard Medical School, Boston, Massachusetts, USA. Boston Eye Group, Boston, Massachusetts, USA. Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. Yeh Tsai-Chu TC Boston Eye Group, Boston, Massachusetts, USA. University of California, San Francisco, San Francisco, California, USA. Melki Samir A SA Harvard Medical School, Boston, Massachusetts, USA. Boston Eye Group, Boston, Massachusetts, USA. Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. eng Journal Article Review 2018 03 26

England Br J Ophthalmol 0421041 0007-1161 cornea glaucoma retina treatment surgery wound healing Competing interests: None declared. 2017 11 19 2018 02 24 2018 03 04 2018 3 28 6 0 2018 3 28 6 0 2018 3 28 6 0 aheadofprint 29581352 bjophthalmol-2017-311643 10.1136/bjophthalmol-2017-311643 29545417 2018 03 16

1468-2079 2018 Mar 15 Br J Ophthalmol Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections. bjophthalmol-2017-311258 10.1136/bjophthalmol-2017-311258 Within a surveillance of the prevalence and causes of vision impairment in high-income regions and Central/Eastern Europe, we update figures through 2015 and forecast expected values in 2020. Based on a systematic review of medical literature, prevalence of blindness, moderate and severe vision impairment (MSVI), mild vision impairment and presbyopia was estimated for 1990, 2010, 2015, and 2020. Age-standardised prevalence of blindness and MSVI for all ages decreased from 1990 to 2015 from 0.26% (0.10-0.46) to 0.15% (0.06-0.26) and from 1.74% (0.76-2.94) to 1.27% (0.55-2.17), respectively. In 2015, the number of individuals affected by blindness, MSVI and mild vision impairment ranged from 70 000, 630 000 and 610 000, respectively, in Australasia to 980 000, 7.46 million and 7.25 million, respectively, in North America and 1.16 million, 9.61 million and 9.47 million, respectively, in Western Europe. In 2015, cataract was the most common cause for blindness, followed by age-related macular degeneration (AMD), glaucoma, uncorrected refractive error, diabetic retinopathy and cornea-related disorders, with declining burden from cataract and AMD over time. Uncorrected refractive error was the leading cause of MSVI. While continuing to advance control of cataract and AMD as the leading causes of blindness remains a high priority, overcoming barriers to uptake of refractive error services would address approximately half of the MSVI burden. New data on burden of presbyopia identify this entity as an important public health problem in this population. Additional research on better treatments, better implementation with existing tools and ongoing surveillance of the problem is needed. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Bourne Rupert R A RRA http://orcid.org/0000-0002-8169-1645 Vision & Eye Research Unit, Anglia Ruskin University, Cambridge, UK. Jonas Jost B JB http://orcid.org/0000-0003-2972-5227 Department of Ophthalmology, Universitätsmedizin, Mannheim, Germany. Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Bron Alain M AM http://orcid.org/0000-0002-7265-931X INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Dijon, France. CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, Dijon, France. Centre des Sciences du Goût et de l'Alimentation, Université Bourgogne Franche-Comté, Dijon, France. Ophthalmology Department, Dijon University Hospital, Dijon, France. Cicinelli Maria Vittoria MV San Raffaele Scientific Institute, Milan, Italy. Das Aditi A Health Education Yorkshire and the Humber, Leeds, UK. Flaxman Seth R SR Department of Mathematics and Data Science Institute, Imperial College London, London, UK. Department of Statistics, University of Oxford, Oxford, UK. Friedman David S DS Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Keeffe Jill E JE LV Prasad Eye Institute, Hyderabad, India. Kempen John H JH Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. Discovery Eye Center, Addis Ababa, Ethiopia. Myungsung Christian Medical Center and Medical School, Addis Ababa, Ethiopia. Leasher Janet J http://orcid.org/0000-0002-8779-5162 Nova Southeastern University, Davie, Florida, USA. Limburg Hans H Health Information Services, Grootebroek, The Netherlands. Naidoo Kovin K African Vision Research Institute, University of Kwazulu-Natal, Brien Holden Vision Institute, Durban, South Africa. Pesudovs Konrad K NHMRC Centre for Clinical Eye Research, Flinders University, Adelaide, South Australia, Australia. Peto Tunde T School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. Saadine Jinan J Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Silvester Alexander J AJ St Pauls Eye Unit, Royal Liverpool University Hospital, Liverpool, UK. Tahhan Nina N Brien Holden Vision Institute, Sydney, New South Wales, Australia. School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. Taylor Hugh R HR Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia. Varma Rohit R Department of Ophthalmology, Keck School of Medicine of USC, Los Angeles, California, USA. Wong Tien Y TY Singapore Eye Research Institute, Duke-NUS Graduate Medical School, National University of Singapore, Singapore. Resnikoff Serge S http://orcid.org/0000-0002-5866-4446 Brien Holden Vision Institute, Sydney, New South Wales, Australia. School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. Vision Loss Expert Group of the Global Burden of Disease Study eng Journal Article 2018 03 15

England Br J Ophthalmol 0421041 0007-1161 epidemiology glaucoma public health Competing interests: JBJ: consultant for Mundipharma (Cambridge, UK), patent holder with Biocompatibles UK (Farnham, Surrey, UK) (Title: Treatment of eye diseases using encapsulated cells encoding and secreting neuroprotective factor and/or anti-angiogenic factor; patent no 20120263794) and patent application with University of Heidelberg (Heidelberg, Germany) (Title: Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia; Europäische Patentanmeldung 15 000 771.4). AMB: consultant for Allergan, Bausch + Lomb, Carl Zeiss Meditec, Théa and VISUfarma. Research grants from Horus. JHK: consultant for Gilead and Santen. SR: consultant for Brien Holden Vision Institute. 2017 08 30 2018 02 12 2018 02 24 2018 3 17 6 0 2018 3 17 6 0 2018 3 17 6 0 aheadofprint 29545417 bjophthalmol-2017-311258 10.1136/bjophthalmol-2017-311258 29421330 2018 04 01

1096-0007 169 2018 Apr Exp. Eye Res. Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse. 61-67 S0014-4835(17)30660-7 10.1016/j.exer.2017.12.013 The present study was designed to identify genomic loci modulating the susceptibility of retinal ganglion cells (RGC) to elevated intraocular pressure (IOP) in the BXD recombinant inbred mouse strain set. IOP was elevated by injecting magnetic microspheres into the anterior chamber and blocking the trabecular meshwork using a handheld magnet to impede drainage. The IOP was then measured over the next 21 days. Only animals with IOP greater than 25 mmHg for two consecutive days or an IOP above 30 mmHg on a single day after microsphere-injection were used in this study. On day 21, mice were sacrificed and the optic nerve was processed for histology. Axons were counted for both the injected and the control eye in 49 BXD strains, totaling 181 normal counts and 191 counts associated with elevated IOP. The axon loss for each strain was calculated and the data were entered into genenetwork.org. The average number of normal axons in the optic nerve across all strains was 54,788 ± 16% (SD), which dropped to 49,545 ± 20% in animals with artificially elevated IOP. Interval mapping demonstrated a relatively similar genome-wide map for both conditions with a suggestive Quantitative Trait Locus (QTL) on proximal Chromosome 3. When the relative axon loss was used to generate a genome-wide interval map, we identified one significant QTL (p < 0.05) on Chromosome 18 between 53.6 and 57 Mb. Within this region, the best candidate gene for modulating axon loss was Aldh7a1. Immunohistochemistry demonstrated ALDH7A1 expression in mouse RGCs. ALDH7A1 variants were not significantly associated with glaucoma in the NEIGHBORHOOD GWAS dataset, but this enzyme was identified as part of the butanoate pathway previously associated with glaucoma risk. Our results suggest that genomic background influences susceptibility to RGC degeneration and death in an inducible glaucoma model. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved. Struebing Felix L FL Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. King Rebecca R Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. Li Ying Y Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. Cooke Bailey Jessica N JN Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, USA. NEIGHBORHOOD consortium Wiggs Janey L JL Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, USA. Geisert Eldon E EE Department of Ophthalmology, Emory University, 1365B Clifton Road NE, Atlanta, GA, 30322, USA. Electronic address: egeiser@emory.edu. eng Journal Article 2018 02 03

England Exp Eye Res 0370707 0014-4835 Butanoate pathway GeneNetwork Glaucoma model QTL mapping Systems genetics 2017 09 13 2017 11 13 2017 12 28 2018 2 9 6 0 2018 2 9 6 0 2018 2 9 6 0 ppublish 29421330 S0014-4835(17)30660-7 10.1016/j.exer.2017.12.013 29396036 2018 03 27

1879-1891 188 2018 Apr Am. J. Ophthalmol. Progress Toward Precisely Diagnosing Autoimmune Retinopathy. xiv-xv S0002-9394(18)30003-5 10.1016/j.ajo.2018.01.002 Sobrin Lucia L Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Electronic address: Lucia_sobrin@meei.harvard.edu. eng Editorial 2018 02 01

United States Am J Ophthalmol 0370500 0002-9394 2017 12 11 2017 12 27 2018 01 01 2018 2 6 6 0 2018 2 6 6 0 2018 2 4 6 0 ppublish 29396036 S0002-9394(18)30003-5 10.1016/j.ajo.2018.01.002 29393489 2018 03 29

1791-3004 17 4 2018 Apr Mol Med Rep Lysyl oxidase inhibition via β-aminoproprionitrile hampers human umbilical vein endothelial cell angiogenesis and migration in vitro. 5029-5036 10.3892/mmr.2018.8508 Lysyl oxidase (LOX) is an enzyme that oxidizes lysine residues in collagens and elastin. It stabilizes or remodels the extracellular matrix and basement membrane of blood vessels. Current oncology studies have revealed that LOX is upregulated in invasive cancer cells and bolstered cell movement, and LOX was observed to promote the angiogenesis and migration of endothelial cells. In the present study, angiogenesis and migration were examined in human umbilical vein endothelial cells (HUVECs). Following cell treatment with 0.1-0.4 mM β-aminoproprionitrile (BAPN), a specific inhibitor of LOX, angiogenesis was analyzed with a fibrin gel in vitro angiogenesis assay kit and migration was examined via a Boyden Chamber assay. Angiogenesis-associated gene expression was investigated with a microarray assay and confirmed with reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results showed that HUVEC angiogenesis substantially increased in the presence of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol 12-myristate 13-acetate (PMA). In addition, LOX inhibition blocked the angiogenesis stimulated by VEGF bFGF and PMA, and the inhibition of LOX reduced the migration of HUVECs. Furthermore, the microarray and RT-qPCR revealed that BAPN downregulated myeloid progenitor inhibitory factor 1, and western blot analysis demonstrated that BAPN decreased the phosphorylation of MAPK and Akt, suggesting that the specific inhibitor of LOX, BAPN, may serve as an alternative strategy for preventing angiogenesis. Shi Lin L Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Zhang Ning N Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Liu Hetao H Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Zhao Lei L Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Liu Jing J Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Wan Juan J Department of Rheumatology and Immunology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Wu Wenyi W Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Lei Hetian H Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Liu Rongqing R Department of Rheumatology and Immunology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. Han Mei M Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China. eng Journal Article 2018 01 26

Greece Mol Med Rep 101475259 1791-2997 J Clin Diagn Res. 2016 Jan;10(1):GC01-4 26894087 J Allergy Clin Immunol. 2011 Jul;128(1):73-81.e4 21497884 J Cell Biochem. 2003 Mar 1;88(4):660-72 12577300 J Mol Histol. 2016 Oct;47(5):503-9 27541034 Cent European J Urol. 2016;69(3):258-263 27729991 Gastroenterol Res Pract. 2013;2013:574260 24391667 J Cereb Blood Flow Metab. 2009 Feb;29(2):385-97 18985053 Blood. 1998 May 1;91(9):3118-26 9558365 J Exp Med. 1997 Apr 7;185(7):1163-72 9104803 Am J Pathol. 2013 Oct;183(4):1293-1305 23928381 Histol Histopathol. 2009 May;24(5):651-60 19283672 Cytokine. 2005 Jun 7;30(5):254-63 15927850 Methods Find Exp Clin Pharmacol. 2010 Sep;32(7):489-97 21069100 Mol Med Rep. 2017 Nov;16(5):6736-6742 28901438 Dis Model Mech. 2015 Jun;8(6):543-51 26035864 Br J Cancer. 2013 Oct 15;109(8):2237-47 24045659 Biomed Res Int. 2013;2013:190486 23555076 Sci Rep. 2016 Nov 03;6:36450 27808256 Nature. 2015 Jun 4;522(7554):41-2 26017311 J Transl Med. 2011 Jul 06;9:105 21733181 Nat Med. 2011 Nov 07;17(11):1359-70 22064426 Am J Manag Care. 2012 Dec;18(13 Suppl):S295-302 23327517 Int J Mol Med. 2015 Dec;36(6):1664-70 26497171 Biomaterials. 2010 May;31(14):3840-7 20185173 Prog Neurobiol. 2007 Oct;83(3):140-8 17868971 Life Sci. 2010 Feb 27;86(9-10):300-8 19951712 Future Oncol. 2014;10(9):1709-17 25145437 J Biochem. 2013 Jan;153(1):13-9 23172303 Drug News Perspect. 2008 May;21(4):218-24 18560621 Circ Res. 2015 Mar 27;116(7):1231-44 25814684 Curr Vasc Pharmacol. 2015;13(3):352-65 26156265 Oncoimmunology. 2016 Aug 12;5(10 ):e1219826 27853641 2017 08 13 2018 01 17 2018 2 3 6 0 2018 2 3 6 0 2018 2 3 6 0 ppublish 29393489 10.3892/mmr.2018.8508 PMC5865964 29384812 2018 03 02

1536-4798 37 4 2018 Apr Cornea Descemetorhexis Without Endothelial Keratoplasty (DWEK): Proposal for Nomenclature Standardization. e20-e21 10.1097/ICO.0000000000001528 Kaufman Aaron R AR Boston University School of Medicine, Boston, MA. Nosé Ricardo M RM Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Pineda Roberto R 2nd Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. eng Journal Article

United States Cornea 8216186 0277-3740 2018 2 1 6 0 2018 2 1 6 0 2018 2 1 6 0 ppublish 29384812 10.1097/ICO.0000000000001528 29326377 2018 02 16

1759-8486 10 3 2018 Mar J Neurointerv Surg Lymphatic malformation with acquired Horner syndrome in an infant. e2 10.1136/neurintsurg-2017-013315.rep An infant presented with right upper eyelid ptosis and was subsequently diagnosed with acquired Horner syndrome. Further evaluation revealed a right-sided cervicothoracic lymphatic malformation. At 13 weeks of age, the child underwent percutaneous intracystic sclerotherapy with a mixture of sodium tetradecyl sulphate and ethanol. Twenty-one weeks after initial treatment, ophthalmic examination showed complete resolution of the blepharoptosis and pupillary miosis. Percutaneous sclerotherapy not only effectively treated the space-occupying lymphatic malformation but also reversed the Horner syndrome that was presumably induced by neural tension (more likely) or compression. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Spors Birgit B Department of Pediatric Radiology, Klinik für Strahlenheilkunde, Charite Hospital, Berlin, Germany. Seemann Joerg J Clinic for Radiology and Neurosurgery, Klinikum Barnim GmbH, Werner Forssmann Krankenhaus, Eberswalde, Brandenburg, Germany. Homer Natalie N Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. Fay Aaron A Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. Center for Vascular Malformation, Werner-Forssmann Krankenhaus, Eberswalde, Germany. eng Journal Article 2018 01 11

England J Neurointerv Surg 101517079 1759-8478 benign lesion pediatrics tumor Competing interests: None declared. 2017 07 11 2017 08 09 2017 08 14 2018 1 13 6 0 2018 1 13 6 0 2018 1 13 6 0 ppublish 29326377 neurintsurg-2017-013315.rep 10.1136/neurintsurg-2017-013315.rep 29165874 2018 02 21

1545-5017 65 4 2018 Apr Pediatr Blood Cancer AML presenting with a preleukemic episode and acquired heterochromia in a child with macrosomia. 10.1002/pbc.26899 Yang Youyang Y http://orcid.org/0000-0003-3447-1401 Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Kazlas Melanie M Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts. Sharma Medha M Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Friedmann Alison A Department of Pediatrics, Massachusetts General Hospital for Children, Boston, Massachusetts. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. eng Letter 2017 11 22

United States Pediatr Blood Cancer 101186624 1545-5009 AML heterochromia macrosomia overgrowth preleukemia pseudohypopyon 2017 06 30 2017 10 23 2017 10 24 2017 11 23 6 0 2017 11 23 6 0 2017 11 23 6 0 ppublish 29165874 10.1002/pbc.26899 29103791 2018 02 20

1549-4713 125 3 2018 Mar Ophthalmology Reversal of Glaucoma Hemifield Test Results and Visual Field Features in Glaucoma. 352-360 S0161-6420(17)31710-4 10.1016/j.ophtha.2017.09.021 To develop a visual field (VF) feature model to predict the reversal of glaucoma hemifield test (GHT) results to within normal limits (WNL) after 2 consecutive outside normal limits (ONL) results. Retrospective cohort study. Visual fields of 44 503 eyes from 26 130 participants. Eyes with 3 or more consecutive reliable VFs measured with the Humphrey Field Analyzer (Swedish interactive threshold algorithm standard 24-2) were included. Eyes with ONL GHT results for the 2 baseline VFs were selected. We extracted 3 categories of VF features from the baseline tests: (1) VF global indices (mean deviation [MD] and pattern standard deviation), (2) mismatch between baseline VFs, and (3) VF loss patterns (archetypes). Logistic regression was applied to predict the GHT results reversal. Cross-validation was applied to evaluate the model on testing data by the area under the receiver operating characteristic curve (AUC). We ascertained clinical glaucoma status on a patient subset (n = 97) to determine the usefulness of our model. Predictive models for GHT results reversal using VF features. For the 16 604 eyes with 2 initial ONL results, the prevalence of a subsequent WNL result increased from 0.1% for MD < -12 dB to 13.8% for MD ≥-3 dB. Compared with models with VF global indices, the AUC of predictive models increased from 0.669 (MD ≥-3 dB) and 0.697 (-6 dB ≤ MD < -3 dB) to 0.770 and 0.820, respectively, by adding VF mismatch features and computationally derived VF archetypes (P < 0.001 for both). The GHT results reversal was associated with a large mismatch between baseline VFs. Moreover, the GHT results reversal was associated more with VF archetypes of nonglaucomatous loss, severe widespread loss, and lens rim artifacts. For a subset of 97 eyes, using our model to predict absence of glaucoma based on clinical evidence after 2 ONL results yielded significantly better prediction accuracy (87.7%; P < 0.001) than predicting GHT results reversal (68.8%) with a prescribed specificity 67.7%. Using VF features may predict the GHT results reversal to WNL after 2 consecutive ONL results. Copyright © 2017 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. Wang Mengyu M Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. Pasquale Louis R LR Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Shen Lucy Q LQ Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts. Boland Michael V MV Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Wellik Sarah R SR Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida. De Moraes Carlos Gustavo CG Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York. Myers Jonathan S JS Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania. Wang Hui H Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts; Institute for Psychology and Behavior, Jilin University of Finance and Economics, Changchun, China. Baniasadi Neda N Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. Li Dian D Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. Silva Rafaella Nascimento E RNE Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts. Bex Peter J PJ Department of Psychology, Northeastern University, Boston, Massachusetts. Elze Tobias T Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts; Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany. Electronic address: tobias-elze@tobias-elze.de. eng Journal Article 2017 11 02

United States Ophthalmology 7802443 0161-6420 2017 05 29 2017 08 28 2017 09 18 2017 11 7 6 0 2017 11 7 6 0 2017 11 7 6 0 ppublish 29103791 S0161-6420(17)31710-4 10.1016/j.ophtha.2017.09.021 28944477 2018 03 25

1531-4995 128 4 2018 Apr Laryngoscope Long-term impact of endoscopic orbital decompression on sinonasal-specific quality of life. 785-788 10.1002/lary.26812 Endoscopic orbital decompression (EOD) is the workhorse surgical intervention for severe thyroid eye disease in Graves disease. Although EOD is a safe and effective procedure, the objective of this study is to determine the impact of orbital decompression on long-term sinonasal-pecific quality of life. Retrospective study of 27 patients who underwent EOD by a single surgeon. The primary endpoint was change in preoperative 22-item Sinonasal Outcomes Test (SNOT-22) score at a minimum of 1 year. The secondary endpoint was to determine whether the performance of septoplasty for surgical access in patients without nasal obstruction impacted domain 1 (i.e., rhinologic domain) and total SNOT-22 scores. The mean follow-up was 25.7 ± 11.4 months. Domain 1 scores significantly increased at the first postoperative visit (P ≤ 0.01) and returned to baseline values between 1 and 3 months. At 1 year, significant improvements in both total score and domain 4 and 5 (psychological and sleep dysfunction, respectively) scores were seen (P < 0.01 for all scores). Septoplasty was not associated with a significant change in SNOT-22 score at 1 year (P = 0.48). Endoscopic orbital decompression is associated at 1 year with a significant improvement in sinonasal-specific quality of life, which is driven by the psychological and sleep dysfunction domains. Adjunctive septoplasty has no significant impact on SNOT-22 scores. 4. Laryngoscope, 128:785-788, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc. Mueller Sarina K SK http://orcid.org/0000-0001-5790-0841 Department of Otolaryngology, University of Erlangen-Nuremberg, Erlangen, Germany. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Miyake Marcel M MM Department of Otolaryngology, Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, Brazil. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Lefebvre Daniel R DR Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Freitag Suzanne K SK Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. Bleier Benjamin S BS Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, U.S.A. eng Journal Article 2017 09 25

United States Laryngoscope 8607378 0023-852X Endoscopy Graves disease orbit paranasal sinus quality of life surgical decompression 2017 06 28 2017 9 26 6 0 2017 9 26 6 0 2017 9 26 6 0 ppublish 28944477 10.1002/lary.26812 28786234 2018 03 25

1531-4995 128 4 2018 Apr Laryngoscope Endoscopic DCR using bipedicled interlacing mucosal flaps. 794-797 10.1002/lary.26730 Obstruction of the nasolacrimal duct is a relatively common condition that affects patients of all ages, races, and sexes. The surgical gold standard for complete nasolacrimal duct obstruction and dacryocystitis is dacryocystorhinostomy (DCR). The purpose of this study was to describe a novel, bipedicled interlacing mucosal sparing flap technique for endoscopic DCR (eDCR). A posteriorly based mucosal flap over the fundus is combined with a novel, anteriorly based mucosal flap over the intraosseus portion of the nasolacrimal duct (NLD). This exposes a wide area of the maxillary bone, allowing for exposure and identification of the NLD/sac complex in a safer, more inferior position. The interlacing mucosal flaps may be replaced at the conclusion of the procedure, thereby minimizing bone exposure and maintaining excellent long-term patency. The authors have utilized this technique in 55 procedures with 100% positive identification of the NLD and lacrimal sac, 0% complication rate, 100% anatomical patency rate, and 96.4% success rate after a minimal follow-up of 6 months. The bipedicled interlacing flap technique for eDCR provides for safe and reproducible identification of the NLD and lacrimal sac while minimizing bone exposure and restenosis rate. The bipedicled interlacing flap technique for eDCR provides for safe and reproducible identification of the NLD and lacrimal sac while minimizing bone exposure and restenosis rate. NA. Laryngoscope, 128:794-797, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc. Mueller Sarina K SK http://orcid.org/0000-0001-5790-0841 Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A. Department of Otolaryngology, University of Erlangen-Nuremberg, Erlangen, Germany. Freitag Suzanne K SK Department of Ophthalmology Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A. Lefebvre Daniel R DR Department of Ophthalmology Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A. Bleier Benjamin S BS Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A. eng Journal Article 2017 08 08

United States Laryngoscope 8607378 0023-852X Allergy/Rhinology Basic Science Clinical 2017 04 17 2017 05 09 2017 8 9 6 0 2017 8 9 6 0 2017 8 9 6 0 ppublish 28786234 10.1002/lary.26730 29274846 2018 03 20

1532-2238 39 2018 Apr Growth Horm. IGF Res. Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity. 19-24 S1096-6374(17)30107-7 10.1016/j.ghir.2017.11.006 Retinopathy of prematurity (ROP) is a multifactorial disease linked to low insulin-like growth factor (IGF)-I levels and perhaps to postnatal inflammation. Here, we investigated the longitudinal postnatal serum concentrations of pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α in relation to IGF-I levels and ROP. The study cohort included 52 infants born before 31 gestational weeks. The infants were screened for ROP and classified as non-ROP (n=33), non-proliferative ROP (stages 1 and 2; n=10), or proliferative ROP (stage 3, all treated for ROP; n=9). Blood samples were collected at birth, 24h after birth, and then weekly until at least 36weeks postmenstrual age (PMA) (i.e., up to 13weeks after birth). Circulating levels of IL-6 and TNF-α were evaluated in relation to circulating IGF-I levels and ROP. IL-6 levels negatively correlated with IGF-I levels between 5 and 8weeks after birth, (p<0.01 to p<0.05). At birth, the IL-6 and TNF-α levels were similar independent of later ROP. Twenty-four hours after birth, both IL-6 and TNF-α levels had increased in infants later treated for ROP (p<0.05). Postnatal, infants treated for ROP had higher IL-6 levels than infants without ROP. The pro-inflammatory response is associated with low IGF-I levels and the development of ROP. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved. Hellgren Gunnel G Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: gunnel.hellgren@gu.se. Löfqvist Chatarina C Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Hansen-Pupp Ingrid I Department of Clinical Sciences, Lund University, Lund, Sweden; Skåne University Hospital, Sweden. Gram Magnus M Department of Clinical Sciences, Lund University, Lund, Sweden; Skåne University Hospital, Sweden. Smith Lois E LE Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, USA. Ley David D Department of Clinical Sciences, Lund University, Lund, Sweden; Skåne University Hospital, Sweden. Hellström Ann A Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. eng R01 EY017017 EY NEI NIH HHS United States U54 HD090255 HD NICHD NIH HHS United States Journal Article 2017 11 27

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