Infectious Disease Institute

 Staphylococcus aureus leads to caspase-1 activation in primary conjunctival goblet cells.

DIRECTOR
Michael S. Gilmore, PhD

ASSOCIATE DIRECTORS
James Chodosh, MD, MPH
Marlene Durand, MD

MEMBERS
See a list of Infectious Disease faculty

 

The Infectious Disease Institute is a Harvard-wide initiative that operates in conjunction with the NIH-sponsored Harvard-wide Program on Antibiotic Resistance/Boston Area Antibiotic Resistance Network. This alliance promotes interdisciplinary collaboration between Harvard affiliate hospitals and industry partners to screen and validate new compounds and for microbial infections—many of which can affect the eye. Members of the Infectious Disease Institute also explore the cellular mechanisms of infection (including host-pathogen interactions) and the genetics of microbial pathogens (such as viruses, bacteria, and fungi) to identify novel therapeutic targets.

Image: Staphylococcus aureus leads to caspase-1 activation in primary conjunctival goblet cells. From: McGilligan VE et al. PLoS One. 2013 Sep 10;8(9):e74010. 

Featured News

Michael Gilmore, PhD, chairs $20 million antibiotic-resistance challenge

Michael Gilmore, PhD, chairs $20 million antibiotic-resistance challenge

April 13, 2017

In March 2017, Michael Gilmore, PhD, Director of the Harvard Infectious Disease Institute, chaired a blue ribbon panel that reviewed the most promising applications for the Antimicrobial Resistance Diagnostic Challenge--a $20 million federal prize competition to develop innovative, rapid point-of-care laboratory diagnostic tests to combat the development, and

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Mass. Eye and Ear team discovers, successfully treats new variant of antibiotic-resistant bacterium

September 15, 2016

Boston, Mass. —  Researchers at Massachusetts Eye and Ear have discovered a new mutation in a highly antibiotic-resistant strain of E. coli that resists clearance by the body’s own immune system by inhibiting white blood cells that ordinarily kill and remove bacteria. In a paper published online today in JAMA Ophthalmology, the researchers describe the case that led them to

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Scientists Discover New Properties of Microbes That Cause Common Eye Infection

Scientists Discover New Properties of Microbes That Cause Common Eye Infection

November 12, 2014

Findings described in Nature Communications

BOSTON, MASS. – Scientists from Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology have used the power of new genomic technology to discover that microbes that commonly infect the eye have special, previously unknown properties. These properties are predicted to allow the bacterium ― Streptococcus pneumonia ― to specifically stick to the surface of the eye, grow, and cause damage and inflammation. Researchers are now using this information to develop new ways to treat

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